Variable Resistance Training in Patients With Osteoarthrosis of the Knee

Variable Resistance Training Versus Conventional Rubber Band Training: Effects on Functional Capacity and Strength in Patients With Osteoarthrosis of the Knee

This is a randomized controlled trial investigating the effect of variable load training in patients with knee osteoarthrosis.

The intervention will consist of resistance training with variable load in knee extension- and flexion. The control group will receive conventional strength training with rubber band.

Outcome measures will be the Knee Osteoarthrosis Outcome Score, functional capacity measured in a sit to stand test, 30m. pace walk and a 9 step stair climb test. Additionally isometric strength in knee flexion- and extension will be measured.

Study Overview

• Status: Unknown
• Conditions: Resistance Training
• Intervention / Treatment: Other: Variable load training; Other: Conventional strength training

• Study Type: Interventional
• Enrollment (Anticipated): 36
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 50 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Knee pain and minimum three of the following
• >50 years
• morning stiffness < 30 min
• crepitation
• bone tenderness
• bone osteophytes
• absence of inflammation

Exclusion Criteria:

• Other causes of symptoms to the knee

Study Plan

How is the study designed?

Design Details

• Primary Purpose: TREATMENT
• Allocation: RANDOMIZED
• Interventional Model: PARALLEL
• Masking: SINGLE

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: Variable load training; The participants will be training two times per week in 10 weeks. Training will consist of variable load training in knee flexion- and extension. Training will be based on symptoms in isometric strength at five different angles of flexion- and extension.	Other: Variable load training; Based on symptoms/strength measured in an isometric maximum strength test at five different angles of knee flexion- and extension, participants will be training with variable load during both concentric and excentric phase of the dynamic movement. Initially participants will start at 40% of symptom limited isometric strength, this will increase to 50% during the training period.
ACTIVE_COMPARATOR: Conventional strength training; The participants will be training two times per week in 10 weeks. Training will consist of a training programme consisting of strength training with rubber bands for hip and knee.	Other: Conventional strength training; Conventional strength training with rubber bands in knee flexion- and extension, additionally hip abduction- and adduction.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in self reported knee function	Knee Osteoarthrosis Outcome Score (100-0, 100 indicating no symptoms and 0 indicating extreme symptoms)	At baseline and 10 weeks follow up

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in functional capacity	Sit to stand test	At baseline and 10 weeks follow up
Change in isometric strength	Isometric strength in knee flexion- and extension	At baseline and 10 weeks follow up
Change in functional capacity	30m pace walk	At baseline and 10 weeks follow up
Change in functional capacity	9 step stair climb test	At baseline and 10 weeks follow up

Collaborators and Investigators

• Sponsor: University College South Denmark

Study record dates

Study Major Dates

• Study Start (ANTICIPATED): October 22, 2018
• Primary Completion (ANTICIPATED): December 31, 2019
• Study Completion (ANTICIPATED): September 1, 2020

Study Registration Dates

• First Submitted: October 18, 2018
• First Submitted That Met QC Criteria: October 25, 2018
• First Posted (ACTUAL): October 26, 2018

Study Record Updates

• Last Update Posted (ACTUAL): October 26, 2018
• Last Update Submitted That Met QC Criteria: October 25, 2018
• Last Verified: October 1, 2018

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Arthritis; Osteoarthritis
• Other Study ID Numbers: Variable Load

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No