- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03772405
Effect of the Nasal Gel "Nascum®-Plus" on Allergic Symptoms (NAPO)
Cross Over Study to Assess the Effect of the Nasal Gel "Nascum®-Plus" on Allergic Symptoms and Inflammatory Cells and Cytokines During and After Allergen Challenge in the Fraunhofer Allergen Challenge Chamber (ACC)
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Niedersachsen
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Hannover, Niedersachsen, Germany, 30625
- Fraunhofer ITEM
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- 1. Able and willing to give written informed consent.
- 2. Male and female subjects, aged 18-65 years. Women will be considered for inclusion if they are: Not pregnant, as confirmed by pregnancy test (see flow chart), and not nursing. Of non-child bearing potential (i.e. physiologically incapable of becoming pregnant, including any female who is pre-menarchial or post-menopausal, with documented proof of hysterectomy or tubal ligation, or meets clinical criteria for menopause and has been amenorrhoeic for more than 1 year prior to the screening visit).
Of childbearing potential and using a highly effective method of contraception during the entire study (vasectomised partner, sexual abstinence - the lifestyle of the female should be such that there is complete abstinence from intercourse from two weeks prior to the first dose of study medication until at least 72 hours after treatment -, implants, injectables, combined oral contraceptives, hormonal IUDs or double-barrier methods, i.e. any double combination of IUD, condom with spermicidal gel, diaphragm, sponge, and cervical cap).
- 3. Body mass index between 18 and 32 kg/m²
- 4. History of seasonal allergic rhinitis to grass pollen
- 5. Positive skin prick test for Dactylis glomerata pollen at screening or within 12 months prior to the screening visit.
- 6. Normal lung function Forced Expiratory Volume in one second (FEV1) ≥ 80 % pred and FEV1/Forced Vital Capacity (FVC) >70% at screening
- 7. Adequate level of rhinitis symptoms in a grass pollen challenge, defined as a Total Nasal Symptom Score (TNSS) of at least 6 (of 12) within the 2-hour grass pollen challenge at performed at the Screening ACC visit (V2).
- 8. TNSS of 3 prior to entering the pollen chamber at screening.
- 9. Non-smokers or ex-smokers since at least 6 months with a history of less than 10 pack years
Exclusion Criteria:
- 1. Any clinically relevant abnormal findings in physical examination, clinical chemistry, hematology, urine analysis, vital signs, lung function or Electrocardiogram (ECG) at screening visit , which, in the opinion of the investigator, may either put the subject at risk because of participation in the study or may influence the results of the study, or the subject's ability to participate in the study
- 2. Past or present disease, which as judged by the investigator, may affect the outcome of this study. These diseases include, but are not limited to, cardiovascular disease, malignancy, hepatic disease, renal disease, hematological disease, neurological disease, endocrine disease or pulmonary disease (including but not confined to chronic bronchitis, emphysema, tuberculosis, bronchiectasis or cystic fibrosis).
- 3. History of an acute infection four weeks prior to the informed consent visit
- 4. Specific Immunotherapy (SIT) within 2 years prior to the study
- 5. Rhinitis of other cause, chronic sinusitis or rhinitis or sinusitis in the last 14 days before entering the study
- 6. Asthma requiring more than inhaled short-acting beta-2 agonists.
- 7. Conditions or factors, which would make the subject unlikely to be able to stay in the Fraunhofer ACC for 4 hours.
- 8. Any contraindication for adrenalin use (e.g. use of local and systemic beta-blockers, angiotensin-converting-enzyme (ACE) inhibitors
- 9. Treatment with antipsychotic medications with antihistaminic effect (e.g. chlorpromazine, levomepromazine, clozapine, olanzapine, tioridazine)
- 10. Use of any medications according to section 8.2 in the period indicated before allergen challenge
- 11. Participation in another clinical trial 30 days prior to enrollment.
- 12. History of drug or alcohol abuse
- 13. Risk of non-compliance with study procedures
- 14. Suspected inability to understand the protocol requirements, instructions and study-related restrictions, the nature, scope, and possible consequences of the study
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Nascum Plus and ACC
In a cross-over design, patients are exposed to pollen in the ACC twice for 4 hours each 3 weeks apart.
Subjects will receive treatment with Nascum Plus either 5 minutes before the first or the second 4 hour pollen challenge.
|
nasal application of nascum plus
4 hours challenge to grass pollen in the allergen challenge chamber (ACC)
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Total Nasal Symptom Score (TNSS)
Time Frame: pre start of challenge and every 20 minutes during 4 hours challenge
|
Change of TNSS assessed during grass pollen challenge in ACC
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pre start of challenge and every 20 minutes during 4 hours challenge
|
Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: Philipp Badorrek, MD, Fraunhofer Gesellschaft
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 18-05 NAPO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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