A Nurse Cohort Study in Xiamen, China

A Prospective Cohort Study of Common Chronic Diseases on Nurses in Xiamen, China: Nurse Cohort Study Xiamen (NCSX)

The Nurse Cohort Study Xiamen (NCSX) is an open-ended prospective cohort study with very broad research aims. The primary objectives of the NCSX is planned to examine genetic, epigenetic, biological, psychological, social, lifestyle and other environmental factors of nurses in relation to incidence and progression of the common chronic diseases, such as hypertension, ischemic heart disease, stroke, diabetes, chronic kidney disease and some cancers, which are emerging with economic development in Xiamen, China. Specifically, we intend to test whether empirically driven hypothesis and emerging risk factors mainly developed in response to observations in economically developed Western societies apply in a population living in a rapid changing lifestyle in China now.

Study Overview

• Status: Recruiting
• Conditions: Hypertension
• Intervention / Treatment: Other: No intervention

Detailed Description

Objectives: To establish a cohort of about 10,000 registered nurses (aged 20 or over) in Xiamen, China; to describe the baseline major risk factors; to analyze their interrelationships; and to examine the risks of incidence and progression of major chronic diseases, such as hypertension, stroke, CKD and cancers, and all-cause and cause-specific mortality by different levels of the risk factors after about 5 years follow-up.

Design: A prospective cohort study. Setting: 7 public hospitals in Xiamen, China. Participants: About 10,000 registered nurses (aged 20 or over) who work in public hospitals in Xiamen, China.

Main outcome: Incidences of common chronic diseases, such as CVD, diabetes, chronic kidney disease, and cancers; progression of these diseases; all cause and specific-cause mortality.

Hypothesis: Relative risks of major risk factors. Results of the study should have strong impact on prevention and control of these diseases and promoting nurses'health in the local population.

• Study Type: Observational
• Enrollment (Estimated): 10000

Contacts and Locations

• Study Contact: Name: Zhibin Li, Ph.D.; Phone Number: 86592-2137364; Email: zhibinli33@hotmail.com
• Study Contact Backup: Name: Haihua Zhu, Master; Phone Number: 86592-2137278

Study Locations

• China
  • Fujian
    • Xiamen, Fujian, China, 361003
      • Recruiting
      • The First Affiliated Hospital of Xiamen University
      • Contact: Zhibin Li, Ph.D.; Phone Number: 86592-2137364; Email: zhibinli33@hotmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

• Registered nurses in public hospitals in Xiamen, China;
• Aged 20 years or over and living in Xiamen for at least 1 year and will not move out of Xiamen for at least 5 years;

Description

Inclusion Criteria:

• Registered nurses of public hospitals in Xiamen, China;
• aged 20 years or over;
• Working in the public hospitals for at least 1 year;
• Signed the informed consent and agreed to participate in the study;
• Assuming not moved out of Xiamen for at least 5 years;

Exclusion Criteria:

• who are unambulatory;
• who are receiving treatment modalities, which , if omitted, may result in immediate life threatening risk such as chemotherapy or radiotherapy for cancer, or dialysis for renal failure.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Nurses; All subjects are registered nurses in Xiamen, China	Other: No intervention; This is a prospective observational study, and there is no intervention.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Incidence rate	The incidence rates of common chronic diseases, such as hypertension, The stroke, CKD and cancers	2019.1.21-2024.12.31

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mortality	All-cause and cause-specific mortality	2019.1.21-2024.12.31

Collaborators and Investigators

• Sponsor: The First Affiliated Hospital of Xiamen University
• Investigators: Study Chair: Weihua Li, Ph.D., The First Affiliated Hospital of Xiamen University

Study record dates

Study Major Dates

• Study Start (Actual): March 20, 2019
• Primary Completion (Estimated): December 31, 2023
• Study Completion (Estimated): December 31, 2028

Study Registration Dates

• First Submitted: January 8, 2019
• First Submitted That Met QC Criteria: January 8, 2019
• First Posted (Actual): January 10, 2019

Study Record Updates

• Last Update Posted (Estimated): November 3, 2023
• Last Update Submitted That Met QC Criteria: November 2, 2023
• Last Verified: November 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Hypertension
• Other Study ID Numbers: KYH2019-002

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No