The Therapeutic Effect of Exercise Training on Patients With Dementia

The Therapeutic Effect of Exercise Training on Old Patients With Dementia: A Randomized Controlled Trial

Sponsors

Lead Sponsor: Taichung Veterans General Hospital

Source Taichung Veterans General Hospital
Brief Summary

This study aimed to clarify whether strength training or aerobic training could bring more benefits for patients with dementia

Detailed Description

Exercise training has been evidenced to bring various of benefits for patients with dementia in past studies. However, whether strength training or aerobic training could bring better benefits has not been confirmed in the past. This study designed to recruit 30 patients with mild dementia in the first year. Every patient will receive strength training using dumbbells, butterfly machine and vertical leg press machine for four weeks. Outcome measures including self care ability, cognitive function, MCP-1, BDNF and IGF-1 levels, and the degree of depression will be recorded before and after the training. In the second year, the investigators also designed to recruit 31 patients with mild dementia. These participants will instead receive aerobic training using stationary bicycle for four weeks. The same outcome measures will be tested as in the first year. Via the results of this study, whether strength training or aerobic training could bring better benefits in dementia patient can thus be elucidated.

Overall Status Completed
Start Date April 9, 2018
Completion Date December 26, 2018
Primary Completion Date December 26, 2018
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
Barthel index 4 weeks
Mini-mental state examination 4 weeks
Montreal Cognitive Assessment 4 weeks
Geriatric Depression Scale 4 weeks
Secondary Outcome
Measure Time Frame
Concentration of serum brain derived neurotrophic factor (BDNF) 4 weeks
Concentration of plasma insulin-like growth factor-1 (IGF-1) 4 weeks
Concentration of plasmamonocyte chemotactic protein-1 (MCP-1) 4 weeks
Enrollment 61
Condition
Intervention

Intervention Type: Device

Intervention Name: Strength training

Description: Using dumbbells, butterfly machine and vertical leg press machine for strength training, 12 repetition maximum weight for 12 repetition, three times a day, five days a week, for a total of four weeks

Arm Group Label: Strength training

Intervention Type: Device

Intervention Name: Aerobic training

Description: Using stationary bicycle to perform cardiopulmonary endurance training in 50-70 heart rate reserve for 20 minutes, five days per week, for a total of four weeks

Arm Group Label: Aerobic training

Eligibility

Criteria:

Inclusion criteria:

1. Patients aged above 65 years old

2. Patients with mild dementia with Mini-mental state examination scoring 15 to 26

Exclusion criteria:

1. Cardiopulmonary diseases or orthopedical conditions that prohibit the patient from receiving exercise training of our programs

2. Cognitive problems that impede the patient to understand and answer the content of our questionnaires.

Gender: All

Minimum Age: 65 Years

Maximum Age: 100 Years

Healthy Volunteers: No

Overall Official
Last Name Role Affiliation
Yuan-Yang Cheng, MDPHD Principal Investigator Department of rehabilitation of Taichung Veterans General Hospital
Location
Facility: Taichung Veterans General Hospital
Location Countries

Taiwan

Verification Date

January 2019

Responsible Party

Type: Sponsor

Keywords
Has Expanded Access No
Condition Browse
Number Of Arms 2
Arm Group

Label: Strength training

Type: Experimental

Description: Muscle strength training programs

Label: Aerobic training

Type: Experimental

Description: Aerobic training programs

Study Design Info

Allocation: Randomized

Intervention Model: Parallel Assignment

Intervention Model Description: comparison of therapeutic effect between aerobic and strength training on dementia patient

Primary Purpose: Treatment

Masking: Double (Investigator, Outcomes Assessor)

Source: ClinicalTrials.gov