- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04009486
Whole Body Vibration and the Brain in OSA
November 17, 2020 updated by: University of California, Los Angeles
Impact of Whole Body Vibration on Sleep Symptoms and the Brain in Obstructive Sleep Apnea
Participants will have an overnight polysomnography (recording apnea-hypopnea index), MRI (brain structure), and a sleep symptoms questionnaire for baseline data.
Participants will then undergo 6 weeks of whole body vibration (using the whole body vibration device), 3 times a week for 30 minutes sessions.
After 6 weeks, participants will have complete another polysomnography, MRI and sleep questionnaire.
Study Overview
Status
Withdrawn
Conditions
Intervention / Treatment
Detailed Description
OSA subjects will be recruited from the UCLA Sleep Disorders Center via recruitment flyers.
When prospective subjects contact the study coordinator, the study will be explained in greater detail, and inclusion and exclusion criteria reviewed.
If the person agrees to participate, appointments for data collection will be made and copies of the informed consent will be mailed for their review for at least 3 days before the study.
Then the Project Coordinator or one of the PI's will contact the prospective subject, answer any questions about the study, and obtain signed, informed consent.
Baseline measures (PSQI, BDI-II, height, weight, vital signs [temperature, heart rate, blood pressure]) will be obtained.
At 6 weeks, baseline measures will be repeated and an overnight polysomnography study will be performed at the subject's home.
All subjects will be given the WBV device at the end of the study.
Delivery of the WBV device to each subject's home will be arranged and the WBV device and pedometer set up by the research team.
Training in the use of the WBV device will be provided inperson and via written instructions.
Phone and e-mail support for the WBV device or any study questions will be available for all study participants.
Subjects will use the device at least 3 times/week, for 30 minutes per session, for 6 weeks.
In addition to the pedometer, a wall calendar will be provided on which subjects will mark the days that they use the WBV device.
Project Coordinator will visit subjects weekly, and as needed, to record pedometer readings, check wall calendar for WBV device use, and to answer any subjects' questions or concerns.
Brain MRI scans will be performed at baseline and after 6 weeks.
An MRI-compatible pulse oximeter, and an air-filled pressure transducer will be connected to the subject to monitor heart rate, O2 saturation, and thoracic wall movement, and then the subject will be positioned in the scanner for data collection.
Study Type
Interventional
Phase
- Not Applicable
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
40 years to 65 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- AHI ≥15
- new diagnosis of moderate to severe OSA (via overnight polysomnography)
- and able to lay flat (requirement for brain MRI)
- must have space and electrical power access for WBV device at their home
Exclusion Criteria:
- other forms of sleep-disordered breathing (such as central sleep apnea, restless legs syndrome, mixed sleep apnea)
- currently using (or will start using during 6-week study period) CPAP or BiPAP or oral appliance for OSA treatment
- recent (<6 months) myocardial infarction
- current pregnancy (if subject is female)
- history of stroke
- diagnosed psychiatric disease (schizophrenia, manic-depressive)
- airway or chest deformities that would interfere with breathing
- mechanical ventilatory support
- renal failure (requiring dialysis)
For brain MRI
- claustrophobia
- metallic-based tattoos
- metallic implants or devices (such as implantable cardioverter-defibrillator, pacemaker, embolic coils, aneurysm clips) or any other material that could be hazardous in MRI scanner
- body weight >300 lbs (restrictions of MRI scanner table)
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Obstructive Sleep Apnea
Subjects will undergo 6 weeks of whole body vibration.
|
Subjects will undergo whole body vibration (standing on a "power plate" device 3 times a week, for 30 minute sessions, for 6 weeks)
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Apnea-Hypopnea Index (AHI)
Time Frame: after 6 weeks of whole body vibration use
|
average number of times per hour during the sleep study/overnight polysomnography that the subject's arterial blood oxygen saturation drops by over 10% from waking baseline
|
after 6 weeks of whole body vibration use
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Sleep Symptoms
Time Frame: after 6 weeks of whole body vibration use
|
symptoms associated with sleep disturbances within the previous month, as recorded by the Pittsburgh Sleep Quality Index Questionnaire (measures sleep symptoms, such as fatigue, sleep quality, sleep duration, etc.The PSQI is a 19-item self-report questionnaire which queries the subject regarding sleep symptoms for the month before the instrument's administration.
Each question is rated on a 0-3-point scale, with a total score range of 0-21.
Higher scores indicate worse sleep symptoms.
A global sum of > 5 indicates a "poor" sleeper.
The PSQI has good validity when compared with overnight polysomnography measures and acceptable reliability (Cronbach's alpha > 0.7; test-retest reliability 0.72-0.86)
|
after 6 weeks of whole body vibration use
|
Brain Structure
Time Frame: after 6 weeks of whole body vibration use
|
high resolution T1 or T2 (diffusion tensor imaging) examination of brain structure changes (baseline and after 6 weeks)
|
after 6 weeks of whole body vibration use
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Anticipated)
April 1, 2020
Primary Completion (Anticipated)
March 1, 2022
Study Completion (Anticipated)
March 1, 2022
Study Registration Dates
First Submitted
July 2, 2019
First Submitted That Met QC Criteria
July 2, 2019
First Posted (Actual)
July 5, 2019
Study Record Updates
Last Update Posted (Actual)
November 19, 2020
Last Update Submitted That Met QC Criteria
November 17, 2020
Last Verified
November 1, 2020
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 19-006112
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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