Correlation Between External Jugular Venous and Superior Vena Cava Central Venous Blood Oxygen Saturation in Patient Under General Anesthesia

After installation of central venous catheter in patients under general anesthesia, paired sample of superior vena cava central venous blood and right external jugular venous blood will be collected and send to central laboratory for venous blood gas analysis. Correlation between superior vena cava central venous blood and right external jugular venous blood oxygen saturation will be determined as primary outcome.

Study Overview

• Status: Not yet recruiting
• Conditions: Central Venous Oxygen Saturation

Detailed Description

All patients age between 18-65 year old who undergoing surgery under general anesthesia and superior vena cava central venous catheter installation anticipated are eligible. The tips of superior vena cava central venous catheter was confirmed by Chest x-ray. Next 1 hour after skin incision, 1 ml of venous blood sample is taken from superior vena cava central venous catheter of right external jugular vein then send to central laboratory for venous blood gas analysis. The demographic data will be recorded. Correlation between superior vena cava central venous blood and right external jugular venous blood oxygen saturation will be determined the primary outcome and partial pressure of carbon dioxide will be determined as a secondary outcome.

• Study Type: Observational
• Enrollment (Anticipated): 40

Contacts and Locations

• Study Contact: Name: Thanist Pravitharangul, MD; Phone Number: 66866633694; Email: thnst_yu@msn.com
• Study Contact Backup: Name: Cherdkiat Karnjanarachata, MD; Phone Number: 66855774747; Email: chird_na@yahoo.com

Study Locations

• Thailand
  • Bangkok
    • Bankok, Bangkok, Thailand, 10400
      • Department of Anesthesiology, Ramathibodi Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 65 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Adult surgical patients undergoing surgery under general anesthesia in institutional operating theaters with superior vena cava central venous catheter installation anticipated.

Description

Inclusion Criteria:

• Written consent obtained from patient or next of kin a day before operation date
• Patient age between 18-65 years old undergoing syrgery under general anesthesia
• Superior vena cava central venous catheter anticipated for CVP mesurement, innotropic or vasopressor administration,pulmonary artery catheter insertion route
• Anticipated right external jugular venous sampling time less than 5 minutes
• The site of blood sample collection easily access during operation

Exclusion Criteria:

• No jugular central venous catheter installation or other route selected
• Duration of paired sample collection more than 10 minutes
• Can not collected blood sample from right external jugular vein within 3 attemps
• The site of blood sample collection difficulty access during operation
• Pateint or next of kin refuse to participate

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Prospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Correlation of venous oxygen saturation	Correlation of venous oxygen saturation between external jugular vein and superior vena cava	1 hour

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Correlation of venous partial pressure of carbon dioxide	Correlation of venous partial pressure of carbon dioxide between external jugular vein and superior vena cava	1 hour
Relationship between superior vena cava central venous and external jugular venous oxygen saturation	Linear regression to determine prediction equation between superior vena cava oxygen saturation and external jugular vein oxygen saturation	1 hour

Collaborators and Investigators

• Sponsor: Ramathibodi Hospital

Study record dates

Study Major Dates

• Study Start (Anticipated): April 1, 2021
• Primary Completion (Anticipated): December 1, 2021
• Study Completion (Anticipated): December 1, 2021

Study Registration Dates

• First Submitted: July 4, 2019
• First Submitted That Met QC Criteria: July 11, 2019
• First Posted (Actual): July 12, 2019

Study Record Updates

• Last Update Posted (Actual): March 9, 2021
• Last Update Submitted That Met QC Criteria: March 5, 2021
• Last Verified: March 1, 2021

More Information

Terms related to this study

• Keywords: internal jugular vein; central venous catheter; central venous oxygen saturation; external jugular venous oxygen saturation; external jugular vein; superior vena cava oxygen saturation
• Other Study ID Numbers: 04072019

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No