- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04048642
Effects of a Plant-Based Diet on Insulin Requirements and Obesity Markers in Obese Adults With T2DM
March 9, 2022 updated by: Thomas M Campbell, University of Rochester
This is a crossover study utilizing a Dietary Approaches to Stop Hypertension (DASH) diet and a whole-food, plant-based diet among subjects with type 2 diabetes who require insulin.
Outcomes are short-term changes in insulin requirements and changes in various biomarkers.
Study Overview
Status
Completed
Intervention / Treatment
Detailed Description
This is a single center, prospective, non-randomized crossover study.
The aim of the study is to perform a comprehensive evaluation of factors that may contribute to improvements in glycemic control in obese patients with type 2 diabetes during a plant-based dietary intervention.
The primary end point will be the change in total daily insulin requirements during the plant-based dietary intervention period compared against a Dietary Approaches to Stop Hypertension (DASH) diet.
Evaluation of insulin requirements will be carried out in three phases of this study: pre-intervention (Phase 1), intervention (Phase 2), and post-intervention (Phase 3).
Each phase is 7 days.
In addition, investigators plan to evaluate the effects of a plant-based diet on glucose homeostasis by estimating the insulin sensitivity index and beta cell function using weekly sampled oral glucose tolerance tests (oGTT) and will explore if these effects correlate with changes in urinary glucose excretion by using weekly sampled urinary tests.
Investigators will also be assessing changes in obesity-related inflammatory biomarkers, stress biomarkers and metabolic markers during the three phases of the study.
Lastly, given the current technological advantages in the field of diabetes monitoring, investigators plan to monitor the glycemic excursion curve using a continuous glucose monitor during the complete study.
Study Type
Interventional
Enrollment (Actual)
15
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
New York
-
Webster, New York, United States, 14580
- UR Medicine/Highland Hospital Nutrition in Medicine Research Center
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Adults (older than 18 years old) of both genders, of all races and ethnicities.
- Pre-existing diagnosis of Type 2 Diabetes Mellitus, as documented in medical records on basal with or without mealtime bolus insulin with no change to total of basal insulin and nutritional baseline insulin dosing > 10% in the 1 month prior to consent and no changes to non-insulin antihyperglycemic medications in the 3 months prior to consent
- If on a GLP-1 analog, on a stable dose for at least 3 months prior to the study enrollment
- If on an SGLT2 inhibitor, on a stable dose for at least 3 months prior to the study enrollment
- BMI of 27 kg/m2 or greater
- Most recent HbA1c (within 6 months prior to consent) between 6.5% and 9.5%
- Fluent in the English language (education about each diet will be in English)
- Willingness and ability to participate in study protocol.
- Agreeable to give informed consent.
Exclusion Criteria:
- Diagnosis of T1DM or type 1.5 diabetes mellitus
- History of liver cirrhosis
- Impaired renal function (GFR < 45 ml/min) within 6 months prior to consent
- History of hyperkalemia (potassium > 5.4 meq/L) within 6 months prior to consent
- Use of an insulin pump or expected to start during the study period
- Use of warfarin (Coumadin)
- Use of daily aspirin 500 mg or more or expected to start during the study period
- Use of daily Vitamin C of 1,000 mg or more, unless willing to stop taking 1 week prior to baseline visit and for duration of study
- Use of antipsychotics or systemic steroids within 3 months prior to consent
- Use of any of the following weight-lowering pharmacotherapy within 3 months prior to consent: phentermine, orlistat, lorcaserin, phentermine/topiramate, bupropion/naloxone
- The use of insulin secretagogues including sulfonylureas and glinides within 3 months prior to consent as this may increase the risk of hypoglycemia and alter assessment of daily insulin requirements during the study
- The use of illicit drugs, defined as active use or use within 3 months prior to consent.
- Engage in high risk alcohol use (defined as more than 4 drinks on any day or more than 14 drinks per week in men and more than 3 drinks on any day or 7 drinks per week in women).
- Individuals who are pregnant or breastfeeding or intend to become pregnant during the duration of the study
- Individuals who are following a vegetarian or vegan diet at the time of consent
- Food allergies or intolerances that will interfere with diet adherence
- Lack of access to a full-size refrigerator (required for storage of 3-4 days of prepared study meals)
- Active malabsorption disorder, including uncontrolled symptomatic inflammatory bowel disease, or bariatric surgery in the past 1 year
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: NA
- Interventional Model: CROSSOVER
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: DASH diet; plant-based diet; DASH diet
Food is provided: 7 days of an ad libitum DASH diet, followed immediately by 7 days of an ad libitum whole food, plant based diet, followed immediately by 7 days of an ad libitum DASH diet again.
|
7 days of a DASH diet
7 days of a WFPB diet
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Change in total daily insulin requirements
Time Frame: 7 Days
|
7 Days
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Changes in glucose excursion curve
Time Frame: 7 days
|
7 days
|
Changes in serum leptin
Time Frame: 7 days
|
7 days
|
Changes in serum adiponectin
Time Frame: 7 days
|
7 days
|
Changes in serum C-peptide levels
Time Frame: 7 days
|
7 days
|
Changes in serum insulin levels
Time Frame: 7 days
|
7 days
|
Change in lipid panel
Time Frame: 7 days
|
7 days
|
Change in hsCRP
Time Frame: 7 days
|
7 days
|
Change in IL-6
Time Frame: 7 days
|
7 days
|
Change in IL-18
Time Frame: 7 days
|
7 days
|
Change in TNF-a
Time Frame: 7 days
|
7 days
|
Change in urinary catecholamines
Time Frame: 7 days
|
7 days
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Jonven Attia, MD, University of Rochester
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
December 1, 2020
Primary Completion (ACTUAL)
February 10, 2022
Study Completion (ACTUAL)
February 10, 2022
Study Registration Dates
First Submitted
August 5, 2019
First Submitted That Met QC Criteria
August 5, 2019
First Posted (ACTUAL)
August 7, 2019
Study Record Updates
Last Update Posted (ACTUAL)
March 25, 2022
Last Update Submitted That Met QC Criteria
March 9, 2022
Last Verified
March 1, 2022
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- STUDY00003764
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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