- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04053608
Human Physiology and Self-Reported Pain Score
Observation of In-Hospital/ In-Home Continuous Monitoring of Human Physiology and Self-Reported Pain Score Among Patients With Moderate-to-severe Cancer Pain
Study Overview
Status
Conditions
Detailed Description
Subjective scores have traditionally been used to measure human pain, such as the visual analog scale (VAS) to determine the presence or absence of pain and its severity. People can only express the pain experienced by dictation, scale, and image depicting the degree of pain. Although this is important information, the self-evaluation method has problems for diagnosis and research purposes. The results of a person's self-assessment depend on past pain experiences and many other cognitive and behavioral factors and therefore change over time. In addition, it is difficult to obtain a reliable comparison between the rewards of different people. When the patient complains of a certain degree of pain, it is impossible to know whether it is equivalent to the same pain described by other patients. Moreover, it is difficult to obtain self-evaluation results among ethnic groups of different natures, such as young people, patients who block the transmission of ideas due to different disease types, and those who are unconscious. A variety of survey-based pain scales and functions have been developed recently, and the utility has improved.
However, because it is still based on self-assessment, it will leave some of the same problems with self-assessment. Developmental measurements of biomarkers or surrogate markers with acute and/or chronic pain have made significant progress over the past few years. Thanks to the development of new and improved technologies, such as in the field of angiography and wearable biosensors, there has been considerable development. Studies have shown that pupils respond to a variety of different stimuli and may predict the presence of pain. There are many different physiological parameters, such as changes in heart rate, pulsating components of the heart cycle, and skin activity, which have been shown to be associated with the presence or absence of pain. From the development of research in this field, it is feasible to develop clinical tools for measuring the presence or absence of acute and/or chronic pain, including cancer pain, using biomarkers or surrogate markers. This objective tool can make more significant advances in clinical pain research and treatment.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Chih Cheng Wu, Master
- Phone Number: 4101 886-4-23592525
- Email: chihcheng.wu@gmail.com
Study Locations
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Taichung, Taiwan, 407
- Recruiting
- Taichung Veterans General Hospital
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Contact:
- Chih Cheng Wu, Master
- Phone Number: 4101 886-4-23592525
- Email: chihcheng.wu@gmail.com
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
There are moderate to severe cancer pain (digital rating scale NRS ≥ 4).
Inclusion conditions:
- Male and female between the ages of 21 and 70
- Cancer patients diagnosed with moderate to severe cancer pain (digital rating scale NRS ≥ 4)
- Ability to provide informed consent
- Be able to commit to using the app during the study and input data as needed
- The subject must have a smart phone such as an iPhone/iPad (at least iPhone 5S)
Exclusion Criteria:
- Previously had myocardial infarction (MI)
- Coronary artery disease is known - previous coronary angioplasty
- A previous stroke occurred, and stroke was defined as a new localized nerve defect lasting more than 24 hours.
- Currently using more than 2 kinds of blood pressure lowering drugs
- Expected life is less than 1 year
- Suffering from asthma or chronic lung disease requires long-term medication or oxygen therapy
- suffering from mental illness, the clinical judgment of the host will affect the participation of the trial, such as dementia
- Unable to comply with the test plan
- Any other acute or chronic medical/physiological condition identified by the moderator as affecting the test results
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Pain Reporting by pain intensity and body map
Time Frame: 30days
|
Patient will report pain intensity in Numerical Rating Scale (NRS) from 0-10 through smartphone and when they suffer from pain.
If possible they will type in the medications they take when they suffer from moderate (NRS>=4) to severe pain (NRS>=7).
Besides, they may choosing the location of pain using a validated body map and logging the time the pain event took place to the nearest 15 minutes.
|
30days
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Symptom Reporting and record of EQ-5D-3L (Quality of Life Questionnaire)
Time Frame: 30 days
|
There are 5 dimensions in the record of EQ-5D-3L (3-level version of the EuroQol-5 Dimension of health questionnaire) including mobility, self-care, usual activities, pain/ discomfort, and anxiety/ depression. There are 3 severity levels (no such problem, some problems/ moderately affected, unable to perform activities or extremely affected) in each dimensions of evaluation. The labels 1-3 describe different severity levels in a dimension and are used to form part of a numerical description of a health state. The second part is the EQ VAS (EuroQol visual analogue scale) records the respondent's self-rated health on a vertical VAS scled from 0 to 100 where the endpoints 0 and 100 are labelled 'The worst health you can imagine' and 'The best health you can imagine'. This information can be used as a quantitative measure of health outcome as judged by the individual respondents |
30 days
|
Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: Chih Cheng Wu, Master, Taichung Veterans General Hospital
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- SF19052B
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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