Gait Parameters and Balance in Patients With Obstructive Lung Diseases

Investigation of Gait Parameters and Balance in Patients With Obstructive Lung Diseases

In the literature, most of the studies examining the gait characteristics and balance separately or examining the relationship between them are on patients with COPD.

No study examining gait parameters in other obstructive pulmonary patients such as bronchiectasis and asthma was found.A convincing link between gait disturbances and falls in COPD patients is still unknown and further research is needed. Therefore, the purpose of our study; gait parameters and balance in individuals with obstructive pulmonary disease. We will also examine the relationship between gait parameters and extrapulmonary clinical indicators of these individuals.

Study Overview

• Status: Recruiting
• Conditions: Gait Disorder, Sensorimotor

Detailed Description

Patients with COPD call walking as one of the most problematic activities in daily life. Patients with COPD walk less in daily life than their healthy peers. Gait characteristics of extrapulmonary comorbidities that probably affect the musculoskeletal and cardiovascular system vary. The gait assessment gives an idea about the biomechanical factors associated with a reduction in walking distance in COPD patients. In patients with COPD, after the onset of shortness of breath or leg fatigue, a decrease in cadence during walking, shortened stride length, an increase in the time spent in the double support period, an increase in the peak ankle dorsi flexion moment is observed. During gait, there is an increase in balance disorders in the mediolateral direction. In addition, patients with COPD walk on a constant speed treadmill with more stride time and less step width variability. Studies have shown that patients with COPD have increased temporal walking characteristics, decreased step and stride length, and increased walking variability.

In the literature, most of the studies that examine gait characteristics and balance separately or examine the relationship between them are on patients with COPD. No study examining gait parameters in other obstructive pulmonary patients such as bronchiectasis and asthma has been found. A persuasive link between walking disorders and falls in COPD patients is still unknown and further research is needed. This study will contribute to clarifying the mechanisms of why the balance studied in patients with COPD is adversely affected.

• Study Type: Observational
• Enrollment (Estimated): 30

Contacts and Locations

• Study Contact: Name: Naciye Vardar-Yagli, PhD; Phone Number: 123 +903123051576; Email: naciyevardar@yahoo.com

Study Locations

• Turkey
  • Ankara, Turkey, 06100
    • Recruiting
    • Naciye Vardar-Yagli
    • Sub-Investigator: Melda Saglam, PhD
    • Contact: Naciye Vardar-Yagli, PhD; Phone Number: 123 +903123051576; Email: naciyevardar@yahoo.com
    • Sub-Investigator: Ebru Calik-Kutukcu, PhD
    • Sub-Investigator: Deniz Inal-Ince, PhD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 65 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

The obstructive lung diseases from every subgroups: COPD, asthma and bronchiectasis patients

Description

Inclusion Criteria for Obstructive Lung Diseases

1. Being diagnosed with obstructive lung disease,
2. Have not experienced acute exacerbation or infection in the last 1 week,
3. To be between 18-65 years,
4. Volunteering for research,
5. To be able to walk and cooperate.

Exclusion Criteria for Obstructive Lung Diseases:

1. Use walking aid or be chronic oxygen support
2. To have orthopedic or neuromuscular comorbidities that may affect walking patterns.
3. Having had lung cancer, sarcoidosis, tuberculosis disease or lung surgery.

Inclusion Criteria for Healthy People 1.18-65 years of age, 2. Volunteer to participate in the research, 3. To be able to walk and cooperate.

Exclusion Criteria for Healthy People

1. Having any cardiopulmonary disease,
2. To have an advanced orthopedic disease that may affect functional capacity measurement and gait patterns.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Obstructive lung diseases group; Having been diagnosed with obstructive pulmonary disease,; No acute exacerbation or infection in the past 1 week, Being between the ages of 18 and 65,
Healthy group; Age and sex matched healthy subjects without orthopedic and chronic diseases

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Gait parameters	Gait parameters will be assessed with Biodex Gait Trainer (Biodex Medical Systems, Shirley, New York) for six minutes.	01.09.2020-08.07.2021

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Functional Balance and Fall Risk	Timed Up and Go Test	01.09.2020-08.07.2021
Respiratory Muscle Strength	Respiratory muscle strength parameters (maximal inspiratory and maximal expiratory pressure) measurement using mouth pressure device	01.09.2020-08.07.2021
Peripheral Muscle Strength	Muscle strength of the knee extensors, hip extensors, shoulder abductors, trunk flexors and trunk extensors will be evaluated by hand dynamometer (Lafayette Manual Muscle Tester Model 01165-USA). Jamar Hand Dynamometer (USA) will measure the hand grip force	01.09.2020-08.07.2021
Cognitive Status	Mini Mental Test	01.09.2020-08.07.2021
Functional Exercise Capacity	6 minute walking test with Moxy device on M.Vastus Lateralis	01.09.2020-08.07.2021

Collaborators and Investigators

• Sponsor: Hacettepe University
• Investigators: Principal Investigator: Naciye Vardar-Yagli, PhD, Hacettepe University

Study record dates

Study Major Dates

• Study Start (Actual): July 17, 2019
• Primary Completion (Estimated): December 1, 2024
• Study Completion (Estimated): December 1, 2024

Study Registration Dates

• First Submitted: August 15, 2019
• First Submitted That Met QC Criteria: August 18, 2019
• First Posted (Actual): August 20, 2019

Study Record Updates

• Last Update Posted (Actual): August 30, 2024
• Last Update Submitted That Met QC Criteria: August 29, 2024
• Last Verified: August 1, 2024

More Information

Terms related to this study

• Keywords: balance; chronic obstructive diseases
• Additional Relevant MeSH Terms: Nervous System Diseases; Respiratory Tract Diseases; Neurologic Manifestations; Lung Diseases; Lung Diseases, Obstructive; Gait Disorders, Neurologic
• Other Study ID Numbers: GO 19/665

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No