- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04097184
Efficacy of Dorso-lateral Prefrontal Cortex Stimulation by tDCS in Motor Conversion Disorder Patients (CONVERSTIM)
Efficacy of Dorso-lateral Prefrontal Cortex Stimulation by tDCS in Patients With Motor Conversion Disorder - Multicentre Randomized Double Blind Assay
Conversion disorder refers to impaired voluntary motor or sensory functions that are not compatible with a well-known neurological condition. This disorder affects up to 30% of hospitalized patients in neurology departments and symptoms persist in 35% of patients after 12 years of evolution. Despite a poor prognosis, no treatments have been validated to date.
The development of non-invasive brain stimulation techniques has allowed the creation of treatments focused on dysfunctional brain regions associated with motor conversion disorder. Hypoactivation of prefrontal dorso-lateral cortex underlies the course of functional motor symptoms. Results of the HYCORE study conducted at Nîmes University Hospital (including 20 patients, clinicaltrial.gov NCT02329626) confirmed these results and related hypoactivation of PFDLC to persistent motor disability at 3 months and 6 months follow-up. Activation of the PFDLC could restore executive control and thus promote the recovery of motor symptoms.
However, in most repeated Transcranial Magnetic Stimulation (rTMS) the primary motor areas were targeted and the clinical improvement was related to self-suggestion induced by the motor response produced.
Among the different techniques, transcranial Direct Current Stimulation (tDCS) is a medical neuromodulation device that delivers a direct, low-intensity electric current to cortical areas, facilitating neuronal activity. Recently, PFDLC stimulation via tDCS has been used to treat several neuropsychiatric disorders and shown to be effective in depression. In addition, this technique has several advantages compared to rTMS: its use is simpler and costs 5 to 8 times less, the device is portable and there is no titration procedure. The tolerance of the tDCS is also better with no risk of epileptic seizure, neuronal depolarization being absent.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Conversion disorder, also called "functional neurological disorder" (DSM-5), refers to impaired voluntary motor or sensory functions that are not compatible with a well-known neurological condition. This disorder affects up to 30% of hospitalized patients in neurology departments (Carson et al. 2000) and the symptoms persist in 35% of patients after 12 years of evolution (Stone et al. 2003). Despite a poor prognosis, no treatments have been validated to date.
The development of non-invasive brain stimulation techniques has allowed the creation of focused treatments on dysfunctional brain regions associated with motor conversion disorder. A hypoactivation of prefrontal dorso-lateral cortex (PFDLC) underlies the course of functional motor symptoms (Spence et al. 2000); (Voon et al.2011); (Conejero et al. 2017). Results of the HYCORE study that the investigators conducted at Nîmes University Hospital (including 20 patients, clinicaltrial.gov NCT02329626) confirmed these results and related hypoactivation of PFDLC to persistent motor disability at 3 months and 6 months follow-up. Activation of the PFDLC could restore executive control and thus promote the recovery of motor symptoms.
However, in the majority of repeated Transcranial Magnetic Stimulation (rTMS) the primary motor areas were targeted (Pollak et al. 2014) and the clinical improvement was related to self-suggestion induced by the motor response produced.
Among the different techniques, transcranial Direct Current Stimulation (tDCS) is a medical neuromodulation device that delivers a direct, low-intensity electric current to cortical areas, facilitating neuronal activity. Recently, PFDLC stimulation via tDCS has been used to treat several neuropsychiatric disorders and shown to be effective in depression. In addition, this technique has several advantages compared to rTMS: its use is simpler and costs 5 to 8 times less, the device is portable and there is no titration procedure. The tolerance of the tDCS is also better with no risk of epileptic seizure, neuronal depolarization being absent.
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Ismael CONEJERO, Dr.
- Phone Number: 07 70 21 62 38
- Email: ismael.conejero@gmail.com
Study Locations
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-
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Lyon, France, 69003
- Not yet recruiting
- Hospices Civils de Lyon Hôpital Edouard Herriot
-
Contact:
- Emmanuel POULET, Pr.
- Phone Number: 04 72 11 00 09
- Email: emmanuel.poulet@chu-lyon.fr
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Sub-Investigator:
- Mohamed SAOUD, Pr.
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Nantes, France, 44000
- Not yet recruiting
- CHU de Nantes
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Contact:
- ANNE SAUVAGET, PHPD
- Phone Number: 02 40 08 47 95
- Email: Anne.sauvaget@chu-nantes.fr
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Sub-Investigator:
- PHILIPPE DAMIER, PHPD
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Toulouse, France, 31000
- Not yet recruiting
- Clinique St Exupery
-
Contact:
- CARLE-TOULEMONDE Guilhem
- Phone Number: 05 32 18 32 39
- Email: guilhemcarle@gmail.com
-
-
Gard
-
Nîmes, Gard, France, 30029
- Recruiting
- Centre Hospitalier Universitaire
-
Contact:
- Anissa MEGZARI
- Phone Number: 04 66 68 30 52
- Email: anissa.megzari@CHU-nimes.fr
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Principal Investigator:
- Ismael CONEJERO, Dr
-
Sub-Investigator:
- Mocrane ABBAR, Dr
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Sub-Investigator:
- Jorge LOPEZ CASTROMAN, Pr.
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Sub-Investigator:
- Eric THOUVENOT, Pr.
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Sub-Investigator:
- Fabricio PEREIRA, M.
-
-
Hérault
-
Montpellier, Hérault, France, 34090
- Not yet recruiting
- Hôpital La Colombière Service de Psychiatrie
-
Contact:
- Jérôme ATTAL, Dr.
- Phone Number: 04 67 33 67 33
- Email: j-attal@chu-montpellier.fr
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Montpellier, Hérault, France, 34295
- Not yet recruiting
- CHU de Montpellier Hôpital Gui De Chauliac Service de Neurologie
-
Contact:
- Caroline ARQUIZAN, Dr
- Phone Number: 04 67 33 74 13
- Email: c-arquizan@chu-montpellier.fr
-
Montpellier, Hérault, France, 34295
- Not yet recruiting
- Hôpital Lapeyronie
-
Contact:
- Emilie OLIÉ, Dr
- Phone Number: 04 67 33 85 81
- Email: e-olie@chu-montpellier.fr
-
Sub-Investigator:
- Philippe COURTET
-
-
Île-de-France
-
Paris, Île-de-France, France, 75012
- Not yet recruiting
- Hôpital Saint-Antoine Service de Psychiatrie APHP
-
Contact:
- Stéphane MOUCHABAC, Dr.
- Phone Number: 01 49 28 27 69
- Email: stephane.mouchabac@aphp.fr
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- The patient must have given his/her informed and signed consent.
- The patient is at least (≥) 18 years old and 65 years old at the most (≤). The risk of an increased frequency of somatic comorbidity, drug co-prescription, and cognitive impairment prompts us to limit recruitment to age 65 in this study.
- The patient is hospitalized or followed in consultation.
- Patient is available for a follow-up of 6 months.
- With current DSM-5 criteria for conversion disorder during more than 10 days, motor type (i.e. with paralysis or motor weakness) and initial EDSS score ≥ 3 or initial WHO Score is ≥ 2
Exclusion Criteria:
- The patient is participating in another interventional trial.
- The patient refuses to sign the consent.
- It is impossible to correctly inform the patient.
- The patient is pregnant or breastfeeding.
- Specialized neurological clinical examination and the performing of brain and medullary MRI reveal an organic neurological involvement.
- Current episode of mania, hypomania, diagnosis of substance abuse/dependence (excluding smoking), diagnosis of schizophrenia over lifetime, severe neurological pathology (epilepsy, stroke, brain tumor).
- Patient with a contraindication to MRI (for patients enrolled in Nîmes).
- Acute eczema at the electrodes loci.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: "active tDCS" group
Patients will benefit from a series of 10 double-blind effective tDCS stimulation sessions over a period of 5 days (Monday to Friday): each stimulation series will include two daily stimulation sessions spaced 3 hours apart for 5 days.
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Neurostimulation with non-implanted electrodes
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Sham Comparator: "sham tDCS" group
Patients will benefit from a series of 10 double-blind placebo tDCS stimulation sessions over a period of 5 days (Monday to Friday): each stimulation series will include two daily stimulation sessions spaced 3 hours apart for 5 days.
|
Neurostimulation with non-implanted electrodes
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Evaluation of the efficacy of tDCS stimulation of the left PFDLC to treat motor disability in patients with conversion disorder 3 months after the intervention.
Time Frame: 3 months after the intervention
|
Evaluation of the efficacy of tDCS stimulation of the left PFDLC to treat motor disability in patients with conversion disorder at 3 months after the stimulation procedure with the EDSS (Expanded Disability Status Scale). The Expanded Disability Status Scale is a rating scale of disability divided into eight systems or functional parameters, four major: pyramidal function, cerebellar function, sensory function and brainstem function; four minor: sphincters,vision, mind and others. An encrypted score of increasing severities (0 to 6 or 7) is given to each functional parameter. The overall score of the scale is measured on a scale of 20 levels (0 to 10 per half-point). Up to level 3.5, the score obtained in each functional parameter and the number of affected functional parameters automaticaly determines the EDSS score. From 4 to 7, the definition of each level is also given by the inability to walk (ability to walk without stopping - need for assistance). |
3 months after the intervention
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Evaluation of the efficacy on motor symptoms at D7 with NIHSS
Time Frame: 7 days after the intervention
|
Evaluation of the efficacy on motor symptoms at Day 7 with the National Institute of Health Stroke Score (NIHSS).
The National Institute of Health Stroke Score includes the following domains : level of consciousness, eye movements, integrity of visual fields, facial movements, arm and leg muscle strength, sensation, coordination, language, speech and neglect.
Each impairment is scored on an ordinal scale ranging from 0 to 2, 0 to 3, or 0 to 4. Item scores are summed to a total score ranging from 0 to 42 (the higher the score, the more severe the stroke).
Duration = 10 minutes
|
7 days after the intervention
|
Evaluation of the persistence of efficacy on motor symptoms at 1 month
Time Frame: 1 month after the intervention
|
Evaluation of the efficacy on motor symptoms at 1 month with National Institute of Health Stroke Score (NIHSS).
The National Institute of Health Stroke Score includes the following domains : level of consciousness, eye movements, integrity of visual fields, facial movements, arm and leg muscle strength, sensation, coordination, language, speech and neglect.
Each impairment is scored on an ordinal scale ranging from 0 to 2, 0 to 3, or 0 to 4. Item scores are summed to a total score ranging from 0 to 42 (the higher the score, the more severe the stroke).
Duration = 10 minutes
|
1 month after the intervention
|
Evaluation of the persistence of efficacy on motor symptoms at 3 months
Time Frame: 3 months after the intervention
|
Evaluation of the efficacy on motor symptoms at 3 months with the National Institute of Health Stroke Score (NIHSS).
The National Institute of Health Stroke Score includes the following domains : level of consciousness, eye movements, integrity of visual fields, facial movements, arm and leg muscle strength, sensation, coordination, language, speech and neglect.
Each impairment is scored on an ordinal scale ranging from 0 to 2, 0 to 3, or 0 to 4. Item scores are summed to a total score ranging from 0 to 42 (the higher the score, the more severe the stroke).
Duration = 10 minutes
|
3 months after the intervention
|
Evaluation of the persistence of efficacy on motor symptoms at 6 months
Time Frame: 6 months after the intervention
|
Evaluation of the efficacy on motor symptoms at 6 months with National Institute of Health Stroke Score (NIHSS).
The National Institute of Health Stroke Score includes the following domains : level of consciousness, eye movements, integrity of visual fields, facial movements, arm and leg muscle strength, sensation, coordination, language, speech and neglect.
Each impairment is scored on an ordinal scale ranging from 0 to 2, 0 to 3, or 0 to 4. Item scores are summed to a total score ranging from 0 to 42 (the higher the score, the more severe the stroke).
Duration = 10 minutes
|
6 months after the intervention
|
Evaluation of the efficacy on motor disability with EDSS score at D7.
Time Frame: 7 days after the intervention
|
Evaluation of the efficacy of the intervention on motor symptoms at D7 using the Expanded Disability Status Scale (EDSS).
The Expanded Disability Status Scale is a method of quantifying disability in multiple sclerosis.
The scale was developed by John F. Kurtzke and an EDSS calculator is available on line.
The EDSS is based on a neurological examination by a clinician, however a number of versions have been developed to enable patient self-administration.The EDSS quantifies disability in eight Functional Systems (FS) by assigning a Functional System Score (FSS) in each of these functional systems: pyramidal, cerebellar, brainstem, sensory, bowel and bladder, visual, cerebral,other.
The scale ranges from 0.0 (normal neurological examination) to 10.0 (death due to multiple sclerosis).
|
7 days after the intervention
|
Evaluation of the persistence of efficacy on motor disability with EDSS at 1 month
Time Frame: 1 month after the intervention
|
Evaluation of the persistence of efficacy of the intervention using the Expanded Disability Status Scale (EDSS) at 1 month.
The Expanded Disability Status Scale is a method of quantifying disability in multiple sclerosis.
The scale was developed by John F. Kurtzke and an EDSS calculator is available on line.
The EDSS is based on a neurological examination by a clinician, however a number of versions have been developed to enable patient self-administration.The EDSS quantifies disability in eight Functional Systems (FS) by assigning a Functional System Score (FSS) in each of these functional systems: pyramidal, cerebellar, brainstem, sensory, bowel and bladder, visual, cerebral,other.
The scale ranges from 0.0 (normal neurological examination) to 10.0 (death due to multiple sclerosis).
|
1 month after the intervention
|
Evaluation of the persistence of efficacy on motor disability with EDSS at 6 months.
Time Frame: 6 month after the intervention
|
Evaluation of the persistence of efficacy of the intervention on motor disability using the Expanded Disability Status Scale (EDSS) at 6 months.The Expanded Disability Status Scale is a method of quantifying disability in multiple sclerosis.
The scale was developed by John F. Kurtzke and an EDSS calculator is available on line.
The EDSS is based on a neurological examination by a clinician, however a number of versions have been developed to enable patient self-administration.The EDSS quantifies disability in eight Functional Systems (FS) by assigning a Functional System Score (FSS) in each of these functional systems: pyramidal, cerebellar, brainstem, sensory, bowel and bladder, visual, cerebral,other.
The scale ranges from 0.0 (normal neurological examination) to 10.0 (death due to multiple sclerosis).
|
6 month after the intervention
|
WHO score at D7
Time Frame: 7 days after the intervention
|
Evaluation of the efficacy of the intervention on motor disability with WHO Performance Status at Day 7. The WHO (World Health Organization) Performance Status is a 5-point scale and is the simplest and fastest indicator to judge the state of autonomy of a person: 0 Fully active, able to carry on all pre-disease performance without restriction
|
7 days after the intervention
|
WHO score at 1 month
Time Frame: 1 month after the intervention
|
Evaluation of the persistence of efficacy of the intervention on motor disability with WHO score at 1 month.The WHO (World Health Organization) Performance Status is a 5-point scale and is the simplest and fastest indicator to judge the state of autonomy of a person: 0 Fully active, able to carry on all pre-disease performance without restriction
|
1 month after the intervention
|
WHO score at 3 months
Time Frame: 3 months after the intervention
|
Evaluation of the persistence of efficacy of the intervention on motor disability with WHO at 3 months.The WHO (World Health Organization) Performance Status is a 5-point scale and is the simplest and fastest indicator to judge the state of autonomy of a person: 0 Fully active, able to carry on all pre-disease performance without restriction
|
3 months after the intervention
|
WHO score at 6 months
Time Frame: 3 months after the intervention
|
Evaluation of the persistence of efficacy of the intervention on motor disability with WHO at 3 months. The WHO (World Health Organization) Performance Status is a 5-point scale and is the simplest and fastest indicator to judge the state of autonomy of a person: 0 Fully active, able to carry on all pre-disease performance without restriction
|
3 months after the intervention
|
CGI (Clinical Global Impression) scores at Day 7
Time Frame: 7 days after the intervention
|
Evaluation of the efficacy on motor disability with Clinical Global Impression score at Day 7. The CGI is a set of two scales with points ranging from 1 -7. The first set describes the Severity of Illness ( 1 = no illness or symptoms of disorder for the past 7 days and 7 = among the most drastically ill patients) The second set describes the Global Improvement (1 = very much improved, 7 = very much worse) |
7 days after the intervention
|
CGI (Clinical Global Impression) score at 3 months
Time Frame: 3 months after the intervention
|
Evaluation of the persistence of efficacy of the intervention on motor disability with Clinical Global Impression scores at 3 months. The CGI is a set of two scales with points ranging from 1 -7. The first set describes the Severity of Illness ( 1 = no illness or symptoms of disorder for the past 7 days and 7 = among the most drastically ill patients) The second set describes the Global Improvement (1 = very much improved, 7 = very much worse) |
3 months after the intervention
|
CGI (Clinical Global Impression) score at 6 months
Time Frame: 6 months after the intervention
|
Evaluation of the persistence of efficacy of the intervention on motor disability with Clinical Global Impression scores at 6 months. The CGI is a set of two scales with points ranging from 1 -7. The first set describes the Severity of Illness ( 1 = no illness or symptoms of disorder for the past 7 days and 7 = among the most drastically ill patients) The second set describes the Global Improvement (1 = very much improved, 7 = very much worse) |
6 months after the intervention
|
Modified Rankin (mRS) score at D7
Time Frame: 7 days after the intervention
|
Evaluation of the efficacy on motor disability with modified Rankin (mRS) scores at D7 months.
The Modified Rankin (mRS) score is a scale ranging from 0 - 6 with 0 being no symptoms at all. 3 = moderate disability despite symptoms but able to walk without asistance and 6 = dead.
|
7 days after the intervention
|
Modified Rankin (mRS) score at 1 month
Time Frame: 1 month after the intervention
|
Evaluation of the efficacy on motor disability with modified Rankin (mRS) scores at 1 month.
The Modified Rankin (mRS) score is a scale ranging from 0 - 6 with 0 being no symptoms at all. 3 = moderate disability despite symptoms but able to walk without asistance and 6 = dead.
|
1 month after the intervention
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Modified Rankin (mRS) score at 3 months
Time Frame: 3 months after the intervention
|
Evaluation of the efficacy on motor disability with modified Rankin (mRS) scores at 1 month.The Modified Rankin (mRS) score is a scale ranging from 0 - 6 with 0 being no symptoms at all. 3 = moderate disability despite symptoms but able to walk without asistance and 6 = dead.
|
3 months after the intervention
|
Modified Rankin (mRS) score at 6 months
Time Frame: 6 months after the intervention
|
Evaluation of the efficacy on motor disability with modified Rankin (mRS) score at 6 months.
The Modified Rankin (mRS) score is a scale ranging from 0 - 6 with 0 being no symptoms at all. 3 = moderate disability despite symptoms but able to walk without asistance and 6 = dead.
|
6 months after the intervention
|
Evaluation of disability related to abnormal movements - CGI at D7.
Time Frame: 7 days after the intervention
|
Evaluate the efficacy on disability related to abnormal movements with Clinical Global Impression scores at Day 7.The CGI is a set of two scales with points ranging from 1 -7. The first set describes the Severity of Illness ( 1 = no illness or symptoms of disorder for the past 7 days and 7 = among the most drastically ill patients) The second set describes the Global Improvement (1 = very much improved, 7 = very much worse) |
7 days after the intervention
|
Evaluation of disability related to abnormal movements - CGI at 1 month.
Time Frame: 1 month after the intervention
|
Evaluate the persistence of efficacy on disability related to abnormal movements with Clinical Global Impression scores at 1 month.The CGI is a set of two scales with points ranging from 1 -7. The first set describes the Severity of Illness ( 1 = no illness or symptoms of disorder for the past 7 days and 7 = among the most drastically ill patients) The second set describes the Global Improvement (1 = very much improved, 7 = very much worse) |
1 month after the intervention
|
Evaluation of disability related to abnormal movements - CGI at 3 months.
Time Frame: 3 months after the intervention
|
Evaluate the persistence of efficacy on disability related to abnormal movements with Clinical Global Impression scores at 3 months. The CGI is a set of two scales with points ranging from 1 -7. The first set describes the Severity of Illness ( 1 = no illness or symptoms of disorder for the past 7 days and 7 = among the most drastically ill patients) The second set describes the Global Improvement (1 = very much improved, 7 = very much worse) |
3 months after the intervention
|
Evaluation of disability related to abnormal movements - CGI at 6 months.
Time Frame: 6 months after the intervention
|
Evaluation of the persistence of efficacy on disability related to abnormal movements with Clinical Global Impression scores at 6 months. The CGI is a set of two scales with points ranging from 1 -7. The first set describes the Severity of Illness ( 1 = no illness or symptoms of disorder for the past 7 days and 7 = among the most drastically ill patients) The second set describes the Global Improvement (1 = very much improved, 7 = very much worse) |
6 months after the intervention
|
Efficacy on depression and anxiety level assessed with the HAD score (HADS) at D7
Time Frame: 7 days after the intervention
|
Evaluation of the efficacy of the intervention on depression and anxiety level with the Hospital Anxiety and Depression Scale (HADS) at D7. The Hospital Anxiety and Depression Scale (HADS) questionnaire (Zigmond and Snaith 1983) validated in French (Lépine et al., 1985) is commonly used in screening for anxio-depressive disorders in studies; it is The HADS questionnaire consists of 14 questions (7 questions about anxiety and 7 questions about depression). Each question is an MCQ with four possible answers. The final score gives a ranking of anxiety and depressive symptoms as follows:
|
7 days after the intervention
|
Efficacy on depression and anxiety level assessed with the HAD score (HADS) at 1 month
Time Frame: 1 month after the intervention
|
Evaluation of the persistence of efficacy on depression and anxiety level with the Hospital Anxiety and Depression Scale (HADS) at 1 month. The Hospital Anxiety and Depression Scale (HADS) questionnaire (Zigmond and Snaith 1983) validated in French (Lépine et al., 1985) is commonly used in screening for anxio-depressive disorders in studies; it is The HADS questionnaire consists of 14 questions (7 questions about anxiety and 7 questions about depression). Each question is an MCQ with four possible answers. The final score gives a ranking of anxiety and depressive symptoms as follows:
|
1 month after the intervention
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Efficacy on depression and anxiety level assessed with the HAD score (HADS) at 3 months .
Time Frame: 3 months after the intervention
|
Evaluation of the persistence of efficacy on depression and anxiety level assessed with the Hospital Anxiety and Depression Scale (HADS) at D7 and persistence at 3 months.The Hospital Anxiety and Depression Scale (HADS) questionnaire (Zigmond and Snaith 1983) validated in French (Lépine et al., 1985) is commonly used in screening for anxio-depressive disorders in studies; it is The HADS questionnaire consists of 14 questions (7 questions about anxiety and 7 questions about depression). Each question is an MCQ with four possible answers. The final score gives a ranking of anxiety and depressive symptoms as follows:
|
3 months after the intervention
|
Efficacy on depression and anxiety level assessed with the HAD score (HADS) at 6 months.
Time Frame: 6 months after the intervention
|
Evaluation of the persistence of efficacy on depression and anxiety level assessed with the HAD score (HADS) at 6 months.The Hospital Anxiety and Depression Scale (HADS) questionnaire (Zigmond and Snaith 1983) validated in French (Lépine et al., 1985) is commonly used in screening for anxio-depressive disorders in studies; it is The HADS questionnaire consists of 14 questions (7 questions about anxiety and 7 questions about depression). Each question is an MCQ with four possible answers. The final score gives a ranking of anxiety and depressive symptoms as follows:
|
6 months after the intervention
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Interaction between time from symptom onset to inclusion in the study, initial severity of abnormal movements and efficacy of motor symptom treatment measured with EDSS at D7
Time Frame: 7 days after the intervention
|
Evaluation of the interaction between time from symptom onset to inclusion in the study, the initial severity of abnormal movements and the efficacy of motor symptom treatment measured with EDSS at D7.
|
7 days after the intervention
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Interaction between time from symptom onset to inclusion in the study, initial severity of abnormal movements and efficacy of motor symptom treatment measured with EDSS at 1 month
Time Frame: 1 month after the intervention
|
Evaluation of the interaction between time from symptom onset to inclusion in the study, the initial severity of abnormal movements and the efficacy of motor symptom treatment measured with EDSS at 1 month.
|
1 month after the intervention
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Interaction between time from symptom onset to inclusion in the study, initial severity of abnormal movements and efficacy of motor symptom treatment measured with EDSS at 3 months
Time Frame: 3 months after the intervention
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Evaluation of the interaction between time from symptom onset to inclusion in the study, the initial severity of abnormal movements and the efficacy of motor symptom treatment measured with EDSS at 3 months.
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3 months after the intervention
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Interaction between time from symptom onset to inclusion in the study, initial severity of abnormal movements and efficacy of motor symptom treatment measured with EDSS at 6 months
Time Frame: 6 months after the intervention
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Evaluation of the interaction between time from symptom onset to inclusion in the study, the initial severity of abnormal movements and the efficacy of motor symptom treatment measured with EDSS at 6 months.
|
6 months after the intervention
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Tolerance to tDCS stimulation D2 - D6 Brunoni
Time Frame: From 2 days to 6 days after the intervention
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Evaluate the tolerance to tDCS stimulation sessions from D2 to D6 with Brunoni's questionnaire.To monitor and evaluate the potential adverse effects of tDCS in patients receiving this treatment, Brunoni et al. (2011) proposed a structured questionnaire.
The patient answers questions regarding symptoms or side-effects on different parts of the body and their severity ranges from 1 - 4 (1 = absent, 2 = mild, 3 = moderate, 4 = severe).
The probability of these symptoms or side-effects being related to the tDCS stimulation treatment is also noted from 1 - 5 ( 1 = none, 2 = remote, 3 = possible, 4 = probable, 5 = definite).
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From 2 days to 6 days after the intervention
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Correlation between putative modification of motor symptoms and changes in activity (rest / motor imagery task) of the PFDLC monitored by brain fMRI at Day 0 and Day 7.
Time Frame: Day 0 and Day 7
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Evaluation of the correlation between putative modification of motor symptoms and changes in activity (at rest or during a motor imagery task) of the PFDLC monitored by functional brain MRI at day 0 and day 7, i.e. search for early response markers to the treatment.
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Day 0 and Day 7
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Evaluation of Dissociative Experiences Scale
Time Frame: 7 days after the intervention
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Evaluate the influence of the initial level of psychic dissociation assessed with the DES scale at D0 on the efficacy of tDCS treatment on the motor's symptoms of CD at day 7
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7 days after the intervention
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Evaluation of Dissociative Experiences Scale
Time Frame: 1 month after the intervention
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Evaluate the influence of the initial level of psychic dissociation assessed with the DES scale at D0 on the efficacy of tDCS treatment on the motor's symptoms of CD
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1 month after the intervention
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Evaluation of Dissociative Experiences Scale
Time Frame: 3 month after the intervention
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Evaluate the influence of the initial level of psychic dissociation assessed with the DES scale at D0 on the efficacy of tDCS treatment on the motor's symptoms of CD
|
3 month after the intervention
|
Evaluation of Dissociative Experiences Scale
Time Frame: 6 month after the intervention
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Evaluate the influence of the initial level of psychic dissociation assessed with the DES scale at D0 on the efficacy of tDCS treatment on the motor's symptoms of CD
|
6 month after the intervention
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Evaluate the evolution of dissociation Experiences Scale
Time Frame: 7 days after the intervention
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Evaluate the influence of the initial level of psychic dissociation assessed with the DES scale at D0 on the efficacy of tDCS treatment on the motor's symptoms of CD
|
7 days after the intervention
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Evaluate the evolution of dissociation Experiences Scale
Time Frame: 1 month after the intervention
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Evaluate the influence of the initial level of psychic dissociation assessed with the DES scale at D0 on the efficacy of tDCS treatment on the motor's symptoms of CD
|
1 month after the intervention
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Evaluate the evolution of dissociation Experiences Scale
Time Frame: 3 month after the intervention
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Evaluate the influence of the initial level of psychic dissociation assessed with the DES scale at D0 on the efficacy of tDCS treatment on the motor's symptoms of CD
|
3 month after the intervention
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Evaluate the evolution of dissociation Experiences Scale
Time Frame: 6 month after the intervention
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Evaluate the influence of the initial level of psychic dissociation assessed with the DES scale at D0 on the efficacy of tDCS treatment on the motor's symptoms of CD
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6 month after the intervention
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Evaluate the concordance of the CGI scale between the neurologist's assessment and the psychiatrist's assessment.
Time Frame: 7 days after the intervention
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Score at the CGI questionnaire
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7 days after the intervention
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Evaluate the concordance of the CGI scale between the neurologist's assessment and the psychiatrist's assessment.
Time Frame: 1 month after the intervention
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Score at the CGI questionnaire
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1 month after the intervention
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Evaluate the concordance of the CGI scale between the neurologist's assessment and the psychiatrist's assessment.
Time Frame: 3 month after the intervention
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Score at the CGI questionnaire
|
3 month after the intervention
|
Evaluate the concordance of the CGI scale between the neurologist's assessment and the psychiatrist's assessment.
Time Frame: 6 month after the intervention
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Score at the CGI questionnaire
|
6 month after the intervention
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Collaborators and Investigators
Investigators
- Principal Investigator: Ismael CONEJERO, Dr., CHU de Nîmes (Nîmes University Hospital)
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
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Other Study ID Numbers
- PHRC-N/2018/IC-01
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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