Exercise Intervention on Conflict Monitoring in Children With Attention-deficit Hyperactivity Disorder (ADHD)

The Effect of Long-term High-intensity Interval Training on Conflict Monitoring in Children With ADHD: an ERP and sLORETA Study

The study mainly investigates the effect of high-intensity interval training on conflict monitoring in children with ADHD by using event-related potential and sLORETA techniques.

Study Overview

• Status: Completed
• Conditions: Exercise Intervention
• Intervention / Treatment: Other: High-intensity interval training

Detailed Description

The present study will have two experiments, one is a cross-section study and the other is intervention study.

As for cross-section study, typical developmental children and children with ADHD will perform the stroop task while recording their brain waves.

The intervention is twice a week for 5 weeks and before and after the intervention, children with ADHD will randomly assign to either an exercise group or control group. They will perform the stroop task while recording their brain waves.

• Study Type: Interventional
• Enrollment (Actual): 110
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Taiwan
  • Taipei, Taiwan
    • National Taiwan Normal University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 7 years to 12 years (Child)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

1. age between 7 and 12 years
2. diagnosed with ADHD by a pediatric psychiatrist, which is not required for TD
3. no history of brain injury or neurological conditions, such as exhibited epileptic seizures, serious head injuries, and periods of unconsciousness.

Exclusion Criteria:

1. cannot follow the instruction
2. cannot complete all the procedure

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Exercise group; The group will receive twice a week for 5 week	Other: High-intensity interval training; 2 times weekly for 5 weeks Circuit training with 4 stations
No Intervention: Control group; The group will be maintained their normal after school activities

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Behavioral performance	reaction time (ms) is generated by computerized task defined as correct responses within the range from 200-1500 ms	Day 0 and post-intervention at Week 5
Behavioral performance	response accuracy (percentage) is generated by computerized task defined as percentage of trials that successfully responded to target stimulus	Day 0 and post-intervention at Week 5

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
N2 & P3 components	Electroencephalographic (EEG) activity will be measured at 64 sites. The amplitude of the N2 is defined as the mean amplitude within a 50-ms interval surrounding the maximal negative peak within a 200- to 400-ms latency window. The amplitude of the P3 is defined as the mean amplitude within a 50-ms interval surrounding the maximal positive peak within a 300- to 800-ms latency window.	Day 0 and post-intervention at Week 5

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Brain activation	To examine sources relating to amplitude in ERPs, source localization will be conducted using standardized low resolution brain electromagnetic tomography (sLORETA) The sLORETA analysis with the ERP data will be selected by four 100 ms bins covering the period from 0 to 200 ms after stimulus-onset (0-50, 50-100, 100-150, and 150-200 ms).	Day 0 and post-intervention at Week 5

Collaborators and Investigators

• Sponsor: National Taiwan Normal University

Study record dates

Study Major Dates

• Study Start (Actual): June 1, 2020
• Primary Completion (Actual): April 30, 2021
• Study Completion (Actual): January 23, 2022

Study Registration Dates

• First Submitted: September 27, 2019
• First Submitted That Met QC Criteria: September 30, 2019
• First Posted (Actual): October 2, 2019

Study Record Updates

• Last Update Posted (Actual): January 18, 2023
• Last Update Submitted That Met QC Criteria: January 14, 2023
• Last Verified: January 1, 2023

More Information

Terms related to this study

• Keywords: ADHD; executive function; HIIT; chronic exercise
• Other Study ID Numbers: 201903HM013

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No