Role of Duplex Doppler in Accurate Diagnosis of Appendicitis

June 4, 2020 updated by: abdelRahman Ahmad abdAllah

Role of Duplex Doppler In Diagnosis of Acute Appendicitis : in Correlation With Surgical Management Outcome

To evaluate the role of duplex doppler in diagnosis of appendicitis compared to CT

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Detailed Description

Acute appendicitis (AA) is the most common acute abdominal condition worldwide [1]

Thus far, the clinical diagnosis of (AA) remains a challenge to emergency physicians and surgeons both in the pediatric and adult populations, as the symptoms are often atypical and overlapped with various other diseases[2],[3].

The accurate diagnosis of AA depends on both clinical presentations and imaging techniques.

To date, US and computed tomography (CT) remain the most common used diagnostic imaging, and CT is considered the gold standard technique to evaluate patients with suspected AA, because of its high sensitivity and specificity [2],[3]. While the associated radiation exposure remains a concern, especially, among children, the elderly and pregnant women, as radiation protection is of major importance [2],[3],[5],[6].

Over recent years, research on various aspects of US imaging in the diagnosis of (AA) has gained major importance due to its radiation protection, broad availability and cost-effectiveness [6].

Therefore,US may be valuable as an initial imaging choice for patients with suspected (AA) or with equivocal clinical presentations [7],[8].

With continuing efforts to improve the diagnostic performance of US, a variety of US findings have been described for use in the setting of suspected appendicitis, including the maximum outer diameter (MOD), periappendiceal fluid, echogenic periappendiceal fat, and loss of the normally echogenic submucosal layer within the appendiceal wall [9] ,[10].

Color Doppler imaging has been utilized as well, with early reports describing no detectable flow in the normal appendix and later reports, with the benefit of improved instrumentation, d describing flow in normal appendices and hyperemia in inflamed appendices [11],[12].

However, objective criteria for interpreting Doppler results generally have not been specifically described [11],[13],[12],[14].

.Spectral Doppler imaging, in contrast to color Doppler imaging, provides inherently objective, quantitative data such as peak systolic velocity (PSV) and resistive index (RI) values. These measurements have found utility in the assessment of the carotid arteries and, for example, both native as well as transplanted hepatic and renal vessels[16],[17]. Early investigations addressed the RI in appendicitis as well, without emphasis on the PSV, using instrumentation that was modern for the time [18],[19],[20].

Study Type

Observational

Enrollment (Anticipated)

100

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: abdelrahman ahmed abdallah, bachelor
  • Phone Number: 01006828820
  • Email: pr.abdo92@gmail.com

Study Contact Backup

Study Locations

  • Egypt
      • Assiut, Egypt, 71511
        • Diagnostic Radiology Department of the assiut university hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

3 years to 60 years (Child, Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Patients with acute abdomen and suspected appendicitis.

Description

Inclusion Criteria:

  • Patients with acute abdomen and suspected appendicitis.

Exclusion Criteria:

  • so Obese and irritable Patients whom satisfactory graded compression US can't be done.
  • pregnant women , children under 3 years old and adults over 60 years old for radiation hazards.
  • patients with renal impairment for contrast hazards.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Case-Only
  • Time Perspectives: Cross-Sectional

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
comparison of duplex Doppler results with CT results
Time Frame: baseline
PSV = peak systolic velocity in cm/second , PDV =peak diastolic velocity in cm/second, and PI =( PSV - PDV)/ PSV taken from the intra mural appendiceal artery then compare with the results of MSCT with contrast of the abdomen.
baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

abdelRahman Ahmad abdAllah

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Anticipated)

July 5, 2020

Primary Completion (Anticipated)

February 15, 2021

Study Completion (Anticipated)

March 15, 2021

Study Registration Dates

First Submitted

October 15, 2019

First Submitted That Met QC Criteria

October 15, 2019

First Posted (Actual)

October 17, 2019

Study Record Updates

Last Update Posted (Actual)

June 5, 2020

Last Update Submitted That Met QC Criteria

June 4, 2020

Last Verified

June 1, 2020

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • US in appendecitis

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

No

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

Yes

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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