- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04148716
microRNAs in Systemic Scleroderma (Dig-ScS)
Identification and Characterization of microRNAs Involved in Esophageal, Gastric and Duodenal Fibrotic Manifestations of Systemic Scleroderma
No studies have investigated the expression of miRNAs in Dig-ScS tissues. In the absence of specific treatment for this frequent impairment in this connectivity, the team proposes to study miRNA profiles in the esophagus and duodenum to identify new therapeutic targets. The team is studying the involvement of pro-fibrotic "key" miRNAs called "FibromiRs", including 3 miRNAs from the DNM3os locus (miR-199a-3p, miR-199a-5p and miR-214 - characterized by the host laboratory) associated with monitoring the response to TGF-β in fibroblasts and their potential interaction with pharmacological treatments such as nintedanib and/or PPARγ agonists. The approach is part of a pilot study that can lead to a larger project after validation of the hypotheses.
It also seems interesting to make a precise anatomopathological description with a gradation of the digestive fibrotic damage in view of the paucity of medical literature in this field
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: nihal martis, ph
- Phone Number: 334 92 03 58 24
- Email: martis.n@chu-nice.fr
Study Locations
-
-
-
Nice, France, 06000
- Recruiting
- Nice hospital
-
Contact:
- nihal martis, ph
- Phone Number: 33 4 92 03 58 24
- Email: martis.n@chu-nice.fr
-
Principal Investigator:
- nihal martis
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Patient Inclusion Criteria
- Subject aged between 18 and 75 years old, meeting the 2013 ACR/EULAR classification criteria for ScS
- Subject under an indication for the performance of esogastro-duodenal fibroscopy (FOGD), the main ones being: anemia, anorexia, weight loss, gastroesophageal reflux disease, dysphagia or odynophagia, ulcer syndrome, suspected portal hypertension
- Supported at Nice University Hospital
- Subject understands and speaks French and is able to give written consent
- Subject affiliated to Social Security or a similar scheme
- Subjects accepting additional digestive biopsies
Control inclusion criteria:
- Subject aged between 18 and 75 years old, without dysimmunitary disease
- Subject within the scope of an indication for the performance of a FOGD as defined by the treating gastroenterologist
- Subject accepting to be serologically tested for HIV and HCV
- Subject understands and speaks French and is able to give written consent
- Subject affiliated to Social Security or a similar scheme
- Subjects accepting additional digestive biopsies
Exclusion Criteria:
- Subject protected by law under guardianship or curatorship, or unable to participate in a clinical study under Article L. 1121-16 of the French Public Health Code
- Subject who has participated in a clinical research study in the last 3 months in which he/she was exposed to a pharmaceutical product or medical device
- Subject who has stayed in a tropical or subtropical country in the last 3 months
- Pregnant or breastfeeding participant
- Subject on a special diet for medical reasons and prescribed by a doctor or dietician (e.g. a low-calorie diet or a diet designed to lower cholesterol levels)
- Subject who regularly consumes large quantities of alcohol, i. e. more than 50 g of pure alcohol per day (e. g. more than 4 glasses of 150 ml wine, more than 4 pints of 250 ml beer, or more than 4 glasses of 40 ml containing strong alcohol)
- Subject who has used an illegal recreational drug in the past 3 months
- Subject who has taken an immunosuppressive or immunomodulatory drug (excluding corticosteroids administered at doses ≤ 10 mg/d PREDNISONE equivalent) within the previous 2 weeks, or for more than 14 consecutive days within the last 3 months
- Subject who has been vaccinated within the last 3 months
- Subject who received a blood transfusion or immunoglobulins in the last 3 months
- Subject stating that he has not been fasting for at least 10 hours
- Subject reporting HIV or HCV status
- Subject who had an infectious episode or was treated with antibiotics during the 4 weeks prior to the visit
- Subject with a positive pregnancy test
- Subject with graft versus host disease, or who has received therapy involving hematopoietic stem cells
- Subject with a severe and/or chronic and/or recurrent pathology, in particular:
- A chronic inflammatory disease of the intestine (Crohn's disease, ulcerative colitis), epidermis (psoriasis, atopic dermatitis), joints (rheumatoid arthritis), nervous system (multiple sclerosis); except ScS.
- A neurodegenerative disease
- Diabetes mellitus
- Subject who has been diagnosed with cancer and has not been in remission for more than 5 years
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
patients
recruitement of 9 patients
|
additional biopsies during a fibroscopy planned in the care
|
control
recruitement of 9 control person
|
additional biopsies during a fibroscopy planned in the care
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
description of the profile of miR based expression on cytokinic treatments and stimuli.
Time Frame: 4 years
|
fundamental research aimed at determining an expression profile of miR as a function of cytokinic treatments and stimuli.
proteins (cytokins) study to describe the profil of miR
|
4 years
|
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start (ACTUAL)
Primary Completion (ANTICIPATED)
Study Completion (ANTICIPATED)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ACTUAL)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 19-AOI-07
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Scleroderma, Systemic
-
Northwestern UniversityCompletedSYSTEMIC SCLERODERMAUnited States
-
Assistance Publique - Hôpitaux de ParisCompletedSYSTEMIC SCLERODERMA | ALLOGENEIC MESENCHYMAL STEM CELLS | ADULTFrance
-
BiocadRecruitingSystemic SclerodermaRussian Federation
-
Rennes University HospitalCompleted
-
University Hospital, LilleRecruiting
-
W. Leroy GriffingRecruitingSystemic Sclerosis | Scleroderma, Systemic | Scleroderma, Diffuse | Diffuse Cutaneous Systemic Sclerosis | Interstitial Lung Disease | Scleroderma | Systemic Sclerosis, Diffuse | Diffuse Systemic Sclerosis | Pulmonary Fibrosis Interstitial | Diffuse Scleroderma | Diffuse Cutaneous Scleroderma | Progressive Systemic... and other conditionsUnited States
-
Boston UniversityRegeneron PharmaceuticalsCompletedSystemic Sclerosis | Scleroderma | Diffuse Systemic Sclerosis | Diffuse SclerodermaUnited States
-
Assistance Publique Hopitaux De MarseilleUnknown
-
University Hospital, Strasbourg, FranceRecruiting
-
University Hospital, LilleCompletedSystemic SclerodermaFrance
Clinical Trials on additional biopsies
-
IRCCS San RaffaeleNot yet recruiting
-
University of PennsylvaniaBiosense Webster, Inc.Enrolling by invitation
-
Federico II UniversityNot yet recruiting
-
IRCCS San RaffaeleRecruiting
-
Rennes University HospitalRecruitingDigestive System Diseases | Crohn Disease | Inflammatory Bowel Disease, Ulcerative Colitis TypeFrance
-
University Hospital, Basel, SwitzerlandGottfried und Julia Bangerter- Rhyner-Stiftung, BaselRecruitingGraft Versus Host Disease | Skin Microbiome | Graft Versus Host Disease in SkinSwitzerland
-
IRCCS San RaffaeleNot yet recruitingDiabetes Mellitus, Type 1 | Ulcerative ColitisItaly
-
University of North Carolina, Chapel HillInterpace Diagnostics CorporationCompletedBarretts Esophagus With Dysplasia | Intramucosal AdenocarcinomaUnited States
-
Assistance Publique - Hôpitaux de ParisCompletedCrohn's DiseaseFrance
-
Academisch Medisch Centrum - Universiteit van Amsterdam...UnknownProstatic Neoplasms | Prostate CancerNetherlands