The Relationship Between Blood Glucose and Satiety Ratings

Participants will be given a drink (and no drink for one of the treatments) prior to a pizza dinner. Ratings on satiety, appetite and desire to eat will be asked with the use of a questionnaire. Blood glucose will also be measured. One hour after the drink, participants will be given a pizza and can eat as much as they want. The pizza remaining will be weighed.

Study Overview

• Status: Unknown
• Conditions: Satiety; Appetite
• Intervention / Treatment: Behavioral: satiety ratings; Dietary supplement: Generation UCAN supplementation; Dietary supplement: Mirexus PhytoSpherix supplementation

Detailed Description

Each participant will receive all three treatments on separate occasions in random order (separated by a week). The three treatments include control (no supplement), carbohydrates - protein (Generation UCAN supplement, 250ml, 10% solution) and carbohydrates alone (Mirexus PhytoSpherix, 250ml, 10% solution). Participants will report to the lab between 4-5 pm and 4 hours after their last meal on day they have not exercised. Participants will record food intake the day of the first experiment and will be asked to replicate both type and quantity for subsequent visits. Upon arrival at the lab, baseline measures (blood glucose as well as rating of satiety ratings, appetite and desire to eat (10-point visual analogue scale). Then the treatment will be given and all the aforementioned variables will be remeasured at 15, 30, 45 and 60 minutes post drink. At 65 minutes, participants will be provided with an ad libitum pizza meal. Participants will be told to eat until they are "comfortably full" (Bellissimo et al., 2008). The pizza provided will be weighed initially and once the participant is done eating and has left the lab, the remaining pizza will be weighed and recorded. The pizza will be a cheese only pizza to minimize any difference in energy intake due to the location of additional items placed on the pizza.

Participants will not be told the true purpose of this experiment, instead they will be told that the pizza meal is a reward for participating in the study. Later, at the conclusion of the study all will be debriefed.

• Study Type: Interventional
• Enrollment (Anticipated): 24
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Canada
  • Ontario
    • London, Ontario, Canada, N6A 3K7
      • Exercise Nutrition Laboratory (Western University)

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 40 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Healthy males and females at the age of 18-40
• sedentary individuals

Exclusion Criteria:

• exercise more than twice per week
• does not like pizza
• do not eat three meals a day
• medications that affect eating patterns
• have metabolic and gastrointestinal diseases

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Single

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: control; no supplement will be provided on the day of the experiment	Behavioral: satiety ratings; questionnaire on satiety ratings will be provided to participants 15, 30, 45 and 60 min after the drink (or no drink)
Experimental: Generation UCAN; carbohydrates - protein (Generation UCAN supplement, 250ml, 10% solution)	Behavioral: satiety ratings; questionnaire on satiety ratings will be provided to participants 15, 30, 45 and 60 min after the drink (or no drink); Dietary supplement: Generation UCAN supplementation; carbohydrates - protein (Generation UCAN supplement, 250ml, 10% solution)
Experimental: Mirexus PhytoSpherix; carbohydrates alone (Mirexus PhytoSpherix, 250ml, 10% solution)	Behavioral: satiety ratings; questionnaire on satiety ratings will be provided to participants 15, 30, 45 and 60 min after the drink (or no drink); Dietary supplement: Mirexus PhytoSpherix supplementation; carbohydrates alone (Mirexus PhytoSpherix, 250ml, 10% solution)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
changes in satiety ratings after the drink	satiety ratings will be asked with the use a 10 point visual analog scale (VAS) questionnaire, 10 being do not want to consume any more food and 1 being strong desire to consume food	15, 30, 45, 60 min after the drink
Food intake	food intake after each treatment will be measured by weighing the left over pizza slices	90 min after the drink

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
changes in appetite ratings after the drink	appetite ratings will be asked with the use a 10 point visual analog scale (VAS), 10 being strong desire to consume food and 1 being no desire to consume food at all	15, 30, 45, 60 min after the drink
changes in blood glucose after the drink	blood glucose will be measured through finger pricks	15, 30, 45, 60 min after the drink
changes in desire to eat ratings	desire to eat ratings will be asked with the use a 10 point visual analog scale (VAS), 10 being no desire to eat at all and 1 being strong desire to eat	15, 30, 45, 60 min after the drink

Collaborators and Investigators

• Sponsor: Western University, Canada

Study record dates

Study Major Dates

• Study Start (Anticipated): February 1, 2020
• Primary Completion (Anticipated): June 30, 2020
• Study Completion (Anticipated): August 31, 2020

Study Registration Dates

• First Submitted: November 26, 2019
• First Submitted That Met QC Criteria: November 28, 2019
• First Posted (Actual): December 3, 2019

Study Record Updates

• Last Update Posted (Actual): January 18, 2020
• Last Update Submitted That Met QC Criteria: January 13, 2020
• Last Verified: November 1, 2019

More Information

Terms related to this study

• Other Study ID Numbers: 115099

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No