- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04192539
The Prospect of Using Serum Taurine Level as a Potential Biomarker for Early Detection of Colorectal Carcinoma and Its Correlation With Other Prognostic Markers
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Two-hundred and fifty Egyptian patients (males and females) who attended National Cancer Institute, Cairo university; most of them were referred from private clinics and non-specialized hospitals, complain with abdominal troubles and gastrointestinal problems and bleeding per rectum, after full investigation, clinical examination, biochemical analysis, screening examination according to their cases (Ultra sound, CT or endoscopy either rectal or colonoscopy) and histopathological examination, we choose 'after their approval' one-hundred patients and six which diagnosed as CRC patients aged (19-69 years old) and excluded the others from participated in these studies because they diagnosed as non-colonic diseases like; Irritable colon, Gastroenteritis, Pancreatitis, Liver flexure or Chronic cholecystitis. According to Histopathological architecture, we divided patients to:
- Inflammatory group number=7.
- Benign tumor group number=8 which was assessed preoperatively and postoperatively.
- Malignant tumor group number=91 Lastly, ten health volunteers were enrolled as a frank control. For all included subjects, the measured biochemical analysis were CBC, ALT, AST, Albumin, Total Bilirubin, Creatinine, Blood urea, Sodium, Potassium, CEA, CA19.9 and Taurine.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Ain Shams University Specialized Hospital
-
Cairo, Ain Shams University Specialized Hospital, Egypt
- Hanaa El Gendy
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
Patients complain of abdominal troubles and gastrointestinal problems and bleeding per rectum
Exclusion Criteria:
Patients refusal,non-colonic diseases like; Irritable colon, Gastroenteritis, Pancreatitis, Chronic cholecystitis
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Control
|
Serum taurine was determined by High Performance Liquid Chromatography (HPLC) according to the pre-column extraction and derivatization methodology of McMahon et al.
In the present work, we use Shimadzu HPLC model LC-10AT
|
Active Comparator: Inflammation
|
Serum taurine was determined by High Performance Liquid Chromatography (HPLC) according to the pre-column extraction and derivatization methodology of McMahon et al.
In the present work, we use Shimadzu HPLC model LC-10AT
|
Active Comparator: Benign group
|
Serum taurine was determined by High Performance Liquid Chromatography (HPLC) according to the pre-column extraction and derivatization methodology of McMahon et al.
In the present work, we use Shimadzu HPLC model LC-10AT
|
Active Comparator: Malignant group
|
Serum taurine was determined by High Performance Liquid Chromatography (HPLC) according to the pre-column extraction and derivatization methodology of McMahon et al.
In the present work, we use Shimadzu HPLC model LC-10AT
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
serum taurine levels
Time Frame: 8 months
|
8 months
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- FWA00007284
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Taurine in Cancer Colon
-
Ferring PharmaceuticalsCompletedColon Cleansing in Preparation for ColonoscopyJapan
-
Cosmo Technologies LtdCross S.A.CompletedColon Staining in Preparation for Colonoscopy
-
KU LeuvenCompletedProtein Fermentation | Toxicity in the ColonBelgium
-
Thomas Jefferson UniversityCompletedBubbles in Colon at Time of ColonoscopyUnited States
-
South Egypt Cancer InstituteCompletedImmunity Factors in Cancer Colon PatientsEgypt
-
Ente Ospedaliero Ospedali GallieraActive, not recruitingTertiary Prevention in Colon CancerItaly
-
Swiss Medical Food AGiOMEDICO AGCompletedCIPN in Adjuvant Colon Cancer Patients | CIPN in Adjuvant Breast Cancer PatientsGermany
-
National Cancer Institute (NCI)NSABP Foundation IncCompletedColon Adenocarcinoma | Stage IIIA Colon Cancer AJCC v7 | Stage IIIB Colon Cancer AJCC v7 | Stage IIIC Colon Cancer AJCC v7 | Stage IIA Colon Cancer AJCC v7 | Stage IIB Colon Cancer AJCC v7 | Stage IIC Colon Cancer AJCC v7United States
-
Gruppo Oncologico del Nord-OvestSeagen Inc.; Servier; Foundation MedicineRecruitingStage II Colon Cancer | Stage III Colon Cancer | HER2-positive Colon Cancer | RAS Wild-type Colon CancerItaly
Clinical Trials on Taurine
-
University of Sao PauloFundação de Amparo à Pesquisa do Estado de São Paulo; Coordenação de Aperfeiçoamento...Completed
-
Zhiming ZhuCompletedPrehypertensionChina
-
University of Illinois at ChicagoNational Cancer Institute (NCI); Rush University Medical CenterActive, not recruitingColorectal CancerUnited States
-
Hospital de Clinicas de Porto AlegreRecruitingDiabetes Mellitus, Type 2Brazil
-
Hamad Medical CorporationUnknownit is a Group of Metabolic Diseases in | Which a Person Has High Blood Sugar, Either | Because the Body Does Not Produce Enough Insulin, | or Because Cells do Not Respond to the Insulin That | is Produced.
-
University of Sao PauloFundação de Amparo à Pesquisa do Estado de São Paulo; Coordenação de Aperfeiçoamento...Not yet recruiting
-
Cambridge Health AllianceStanley Medical Research Institute; Mclean HospitalTerminated
-
Mclean HospitalCompletedBipolar Disorder | Mania | Bipolar DepressionUnited States
-
Third Military Medical UniversityUnknownDiabetes | Taurine | Lower Extremity Artery DiseaseChina