- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04196335
I Can sEe Left Atrial Appendage (ICELAA) Clinical Study (ICELAA)
March 30, 2022 updated by: Boston Scientific Corporation
The primary objective of this study is to assess the efficacy and safety of using intra-procedural intracardiac echocardiography (ICE) for WATCHMAN FLX Device implants in subjects with non-valvular atrial fibrillation to reduce the risk of stroke.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
100
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Skejby, Denmark
- Aarhus Universitetshospital
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Massa, Italy
- Fondazione Toscana Gabriele Monasterio
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Mestre, Italy
- Ospedale dell'Angelo
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Milan, Italy
- Centro Cardiologico Fondazione Monzino
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Vicenza, Italy
- Ospedale San Bortolo
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Barcelona, Spain
- Hospital de Sant Pau
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Oxford, United Kingdom
- John Radcliffe
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- The subject is of legal age to participate in the study per the laws of their respective geography;
- The subject has documented paroxysmal, persistent, permanent or long-term/longstanding persistent non-valvular atrial fibrillation (i.e., the subject does not have mitral stenosis or a mechanical heart valve);the subject has not been diagnosed with rheumatic mitral valvular heart disease);
- The subject is deemed by the treating physician to be suitable for the protocol defined pharmacologic regimens;
- The subject has a calculated CHA2DS2-VASc score of 2 or greater;
- The subject is able to undergo ICE examinations;The subject is able to undergo ICE(which will be used during the index procedure) and TEE (which will be performed at 45 days and may also be performed at baseline);
- The subject is able to understand and willing to provide written informed consent to participate in the trial;
- The subject is able and willing to return for required follow-up visits and examinations.
Exclusion Criteria:
- Subjects who are currently enrolled in another investigational study or registry that would directly interfere with the current study, except when the subject is participating in a mandatory governmental registry, or a purely observational registry with no associated treatments. Each instance must be brought to the attention of the sponsor to determine eligibility, regardless of type of co-enrollment being proposed;
- The subject requires long-term anticoagulation therapy for reasons other than AF-related stroke risk reduction, for example due to an underlying hypercoaguable state (i.e., even if the device is implanted, the subjects would not be eligible to discontinue OAC due to other medical conditions requiring chronic warfarin therapy);
- The subject has a history of atrial septal repair or has an ASD/PFO device;
- The subject has an implanted mechanical valve prosthesis in any position;
- The subject currently or has had any documented history of, New York Heart Association Class IV Congestive Heart Failure;
- The subject is of childbearing potential and is or plans to become pregnant during the time of the study (method of assessment upon study physician's discretion).
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
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Experimental: single-arm
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use of intra-procedural intracardiac echocardiography during Watchman FLX devices
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Rate of Device Leak
Time Frame: 45 days
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Rate of significant leak (>5 mm) as assessed by TEE at 45 days' post-implant.
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45 days
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Jens Erik Nielsen-Kudsk, MD, Aarhus University Hospital Skejby
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
July 29, 2020
Primary Completion (Actual)
September 24, 2021
Study Completion (Actual)
September 24, 2021
Study Registration Dates
First Submitted
November 5, 2019
First Submitted That Met QC Criteria
December 10, 2019
First Posted (Actual)
December 12, 2019
Study Record Updates
Last Update Posted (Actual)
March 31, 2022
Last Update Submitted That Met QC Criteria
March 30, 2022
Last Verified
March 1, 2022
More Information
Terms related to this study
Other Study ID Numbers
- S2459
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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