The Effect of Degree of Rice-polishing on Glycaemic Response

To investigate the effects of rice polishing on glycaemic and insulinaemic response in healthy Chinese male volunteers.

Study Overview

• Status: Completed
• Conditions: Obesity; Diabetes Mellitus
• Intervention / Treatment: Other: Glucose Reference 1; Other: Glucose Reference 2; Other: Glucose Reference 3; Other: Brown Rice; Other: 3 % polished rice; Other: 6 % polished rice; Other: 9 % polished rice; Other: 20 % Polished rice

Detailed Description

There will be a total of 8 test session. Each session will last for 3.5 hours. At each test session, volunteers will be served with test meal and blood will be collected. After an overnight fast, subjects will visit the research center. Two fasting capillary blood samples will be collected via fingerprick. Following the fasting samples, subject will consume the test meals. Further blood samples will be collected at 15, 30, 45, 60, 90, 120, 150, 180 minutes after the ingestion of test meal. These samples will be used to analyses for whole capillary blood glucose. At every 30 minute interval, samples will be collected for analysis of capillary plasma insulin.

• Study Type: Interventional
• Enrollment (Actual): 14
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Singapore
  • Singapore, Singapore, 117599
    • Clinical Nutrition Research Centre

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 21 years to 60 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Male
• Chinese ethnicity
• Age ≥21 and ≤ 60 years
• Body mass index between 18.5 to 25 kg/m2
• Normal blood pressure =<140/90 mmHg
• Fasting blood glucose <6.0 mmol/L
• In general good health

Exclusion Criteria:

• Current smoker
• Have any metabolic diseases (such as diabetes, hypertension etc)
• Do not have known glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
• Have medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics)
• Have intolerances or allergies to any foods
• Currently partake in sports at the competitive and/or endurance levels
• Intentionally restrict food intake

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

8

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: Glucose Reference 1; Glucose solution 1	Other: Glucose Reference 1; 50 g of glucose dissolved in 250 ml of water (First glucose control visit)
Other: Glucose Reference 2; Glucose solution 2	Other: Glucose Reference 2; 50 g of glucose dissolved in 250 ml of water (Second glucose control visit)
Other: Glucose Reference 3; Glucose solution 3	Other: Glucose Reference 3; 50 g of glucose dissolved in 250 ml of water (Third glucose control visit)
Experimental: Brown Rice; Cooked brown rice	Other: Brown Rice; Unpolished brown rice containing 50 g of available carbohydrate was cooked using a rice cooker (Toyomi) at a ratio of rice to water of 1: 2
Experimental: 3 % polished rice; Cooked 3 % polished rice	Other: 3 % polished rice; 3% polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2
Experimental: 6 % polished rice; Cooked 6 % polished rice	Other: 6 % polished rice; 6% polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2
Experimental: 9 % polished rice	Other: 9 % polished rice; 9 % polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2
Experimental: 20 % Polished rice; Cooked 20 % Polished rice (White Rice)	Other: 20 % Polished rice; White rice (20% polished rice), containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Glucose	Whole capillary blood glucose will be measure using Hemocue analyser	Up to 180 minutes

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Insulin	Capillary plasma will be measure using Cobas analyser	Up to 180 minutes

Collaborators and Investigators

• Sponsor: Clinical Nutrition Research Centre, Singapore

Study record dates

Study Major Dates

• Study Start (Actual): February 13, 2019
• Primary Completion (Actual): July 26, 2019
• Study Completion (Actual): June 18, 2020

Study Registration Dates

• First Submitted: January 11, 2020
• First Submitted That Met QC Criteria: January 11, 2020
• First Posted (Actual): January 14, 2020

Study Record Updates

• Last Update Posted (Actual): August 20, 2021
• Last Update Submitted That Met QC Criteria: August 19, 2021
• Last Verified: August 1, 2021

More Information

Terms related to this study

• Other Study ID Numbers: 2018/01079

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No