The Glycemic Effect of Added Sugar on Bake Beans (GIF)

To investigate the effect of added sugar to bake beans on glycemic and insulinemic response.

Study Overview

• Status: Completed
• Conditions: Obesity; Diabetes Mellitus, Type 2; PreDiabetes
• Intervention / Treatment: Other: Glucose Reference 1; Other: Glucose Reference 2; Other: Glucose reference 3; Other: Sucrose; Other: Regular Bake beans in tomato sauce; Other: Bake beans in tomato sauce, reduced sugar; Other: Bake beans in tomato sauce, low GI

Detailed Description

There will be a total of 7 test session. Each session will last for 3 hours. At each test session, volunteers will be served with 7 test meals and blood will be collected. After an overnight fast, subjects will visit the research center. Two fasting capillary blood samples will be collected via fingerpick. Following the fasting samples, volunteers will consume the test meals. Further blood samples will be collected at 15, 30, 45, 60, 90, 120, 150, 180 minutes after the ingestion of test meal. These samples will be used to analyses for whole capillary blood glucose. At every 30 minute interval, samples will be collected for analysis of capillary plasma insulin.

• Study Type: Interventional
• Enrollment (Actual): 12
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Singapore
  • Singapore, Singapore, 117599
    • Clinical Nutrition Research Centre

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 21 years to 60 years (ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Chinese ethnicity
• Age ≥21 and ≤ 60 years
• Body mass index between 18.5 to 25 kg/m2
• Normal blood pressure <140/90 mmHg
• Fasting blood glucose <6.0 mmol/L
• In general good health

Exclusion Criteria:

• Current Smoker
• have any metabolic diseases (such as diabetes, hypertension etc)
• have known glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
• having medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics)
• have intolerances or allergies to any foods
• partake in sports at the competitive and/or endurance levels
• intentionally restrict food intake

Study Plan

How is the study designed?

Design Details

• Primary Purpose: OTHER
• Allocation: RANDOMIZED
• Interventional Model: CROSSOVER
• Masking: NONE

Number of Arms

7

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
OTHER: Glucose Reference 1; Glucose solution containing 30 g of glucose	Other: Glucose Reference 1; 30 g of glucose dissolved in 250 ml of water
OTHER: Glucose Reference 2; Glucose solution 2 containing 30 g of glucose	Other: Glucose Reference 2; 30 g of glucose dissolved in 250 ml of water
OTHER: Glucose Reference 3; Glucose solution 3 containing 30 g of glucose	Other: Glucose reference 3; 30 g of glucose dissolved in 250 ml of water
EXPERIMENTAL: Sucrose; Sucrose solution containing 30 g of sucrose	Other: Sucrose; 30 g of Sucrose dissolved in 250 ml of water
EXPERIMENTAL: Regular Bake beans in tomato sauce; Bake bean in tomato sauce with high levels of sucrose (37%)	Other: Regular Bake beans in tomato sauce; Bake beans in tomato sauce containing 14 g of sugar
EXPERIMENTAL: Bake beans in tomato sauce, reduced sugar; Bake bean in tomato sauce with medium levels of sucrose (29.9%)	Other: Bake beans in tomato sauce, reduced sugar; Bake beans in tomato sauce containing 12.2 g of sugar
EXPERIMENTAL: Bake beans in tomato sauce, low GI; Bake bean in tomato sauce with low levels of sucrose (18.5%)	Other: Bake beans in tomato sauce, low GI; Bake beans in tomato sauce containing 7.2 g of sugar

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Glucose [	Whole capillary blood glucose will be measure using Hemocue analyser	Up to 180 minutes

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Insulin	Capillary plasma will be measure using Cobas analyser	Up to 180 minutes

Collaborators and Investigators

• Sponsor: Clinical Nutrition Research Centre, Singapore

Study record dates

Study Major Dates

• Study Start (ACTUAL): August 20, 2018
• Primary Completion (ACTUAL): April 17, 2019
• Study Completion (ACTUAL): April 17, 2019

Study Registration Dates

• First Submitted: March 7, 2019
• First Submitted That Met QC Criteria: March 7, 2019
• First Posted (ACTUAL): March 11, 2019

Study Record Updates

• Last Update Posted (ACTUAL): July 17, 2020
• Last Update Submitted That Met QC Criteria: July 16, 2020
• Last Verified: March 1, 2019

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Glucose Metabolism Disorders; Metabolic Diseases; Endocrine System Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2
• Other Study ID Numbers: 2016/00926

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No