Impact of Tooth Loss and Denture on Oral Senses and Food Preferences (AlimaPAC)

Impact of Complete Tooth Loss and Denture on Oral Sensory Abilities and Food Preference

Tooth loss impacts taste abilities and food intake. Present study aims at pertaining the impact of teeth loss and the replacement by means of complete denture on taste and trigeminal abilities, and on food preferences, and taste appetence.

Study Overview

• Status: Unknown
• Conditions: Tooth-loss
• Intervention / Treatment: Procedure: Tooth removal and their replacement by means of a denture

Detailed Description

Two groups of participants will be included. Participants wearing complete denture for at least one year (n=20) and their matched controls for age, sex, tobacco, and saliva secretion (n=20). Their oral sensory abilities of participants will be assessed including taste (electrogustometric thresholds, chemical taste identification ability) and trigeminal quantitative sensory testing. Food preferences and selectivity (Maitre et al., 2014) and taste appetence (Deglaire et al., 2012) will also be assessed.

• Study Type: Interventional
• Enrollment (Anticipated): 40
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Adeline Braud, Doctor; Phone Number: 01 40 19 39 87; Email: adeline.braud@aphp.fr
• Study Contact Backup: Name: Yves Boucher, Professor

Study Locations

• France
  • Paris, France, 75002
    • Service odontologie Hôpital Rothschild
    • Contact: Adeline Braud, Dr; Phone Number: 01 40 19 39 87; Email: adeline.braud@aphp.fr

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 79 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

Study Group : being completely edentulous and wearing denture for at least one year, wearing denture during meals, with clean and stable dentures. Controls:

controls Group : dentate subjects (25 teeth at leas, non endodontically treated) with molars in Angle's Class I occlusion, having no functional disturbance of mastication and not undergoing dental treatment at the time of the recording. Matched with subjects of the study group for age, sex, tabacco consumption, and saliva flow rate.

Exclusion Criteria:

• Aged under 18 or over 80 Y,
• not consenting to participate
• suffering from dental
• periodontal or gum pain for the last month.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
No Intervention: Control
Experimental: Tooth removal; Tooth removal and their replacement by means of a denture Teeth have been removed and replaced by means of dentures for at least one year	Procedure: Tooth removal and their replacement by means of a denture; Teeth have been removed and replaced by means of dentures for at least one year

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
taste detection thresholds	Using an Electrogustometer	up to 30 days

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Chemical taste identification ability	Using taste strips (Burghard)	up to 30 days
Quantitative sensory testing	Using an algometer, von frey filament, a thermode.	up to 30 days
Food preferences and selectivity	Questionnaire food selectyivity and preference (Maitre et al., 2014)	up to 30 days
Taste appetence	Questionnaire PrefQuest (Deglaire et al., 2012)	up to 30 days

Collaborators and Investigators

• Sponsor: Assistance Publique - Hôpitaux de Paris
• Investigators: Principal Investigator: Adeline Braud, Doctor, Assistance Publique - Hôpitaux de Paris

Study record dates

Study Major Dates

• Study Start (Anticipated): July 1, 2020
• Primary Completion (Anticipated): July 1, 2020
• Study Completion (Anticipated): July 1, 2020

Study Registration Dates

• First Submitted: February 20, 2020
• First Submitted That Met QC Criteria: February 20, 2020
• First Posted (Actual): February 21, 2020

Study Record Updates

• Last Update Posted (Actual): February 21, 2020
• Last Update Submitted That Met QC Criteria: February 20, 2020
• Last Verified: February 1, 2020

More Information

Terms related to this study

• Keywords: denture; Teeth loss; edentulousness; tast; trigeminal senses; oral sensory ability
• Additional Relevant MeSH Terms: Stomatognathic Diseases; Periodontal Diseases; Mouth Diseases; Tooth Diseases; Tooth Loss
• Other Study ID Numbers: APHP190340

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No