- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04343365
Generating Novel Therapeutic Strategies Based on Evolutionary Tumor Board
February 13, 2024 updated by: H. Lee Moffitt Cancer Center and Research Institute
Feasibility of Generating Novel Therapeutic Strategies Based on Evolutionary Tumor Board in Cancer Patients
This study will evaluate the ability of a multidisciplinary group, the Evolutionary Tumor Board (ETB), to develop therapeutic strategies in patients without curative options.
Study Overview
Status
Recruiting
Conditions
Intervention / Treatment
Study Type
Observational
Enrollment (Estimated)
35
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Alaa Taha
- Phone Number: 813-745-7025
- Email: alaa.taha@moffitt.org
Study Locations
-
-
Florida
-
Tampa, Florida, United States, 33613
- Recruiting
- Moffitt Cancer Center
-
Sub-Investigator:
- Michael Schell, PhD
-
Principal Investigator:
- Christine Chung, MD
-
Sub-Investigator:
- Joel Brown, PhD
-
Sub-Investigator:
- Alexander Anderson, PhD
-
Contact:
- Alaa Taha
- Phone Number: 813-745-7025
- Email: alaa.taha@moffitt.org
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Sampling Method
Non-Probability Sample
Study Population
Participants who are patients at Moffitt Cancer Center
Description
Inclusion Criteria:
- Participant must be considered likely incurable given a standard of care. This is inclusive of participants in remission but at high risk of recurrence, with suboptimal responses to previous therapy, or with many potentially beneficial, but not curative options for care.
- Participant must have a life expectancy greater than 3 months
- Participant must have an ECOG performance status 0-2
- Participant and primary Oncologist are willing to consider the therapeutic strategies recommended by the ETB
- Willingness to be followed over time and allowing collection of clinical data including scans and serial blood sampling.
Exclusion Criteria:
- None
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Case-Only
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Participants Reviewed by ETB
Participants clinical history, available therapeutic options, and outcome expectations will be presented to the Evolutionary Tumor Board (ETB) along with images and pathology.
Strategies and models will be presented regarding additional evolutionary ideas that can be applied.
|
The ETB consists of evolutionary biologists, mathematicians, research scientists, statisticians,data scientists, radiologists, pathologists, oncologists (surgical, radiation, medical, and pediatric), and clinical trial coordinators.The ETB will generate hypotheses, mathematical models, and experiments from the discussion towards further integration of evolutionary ideas towards therapeutic strategies for participants.
The ETB will collect data through a chart review regarding adherence and results of ETB recommendation
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
ETB developing therapeutic strategies
Time Frame: Baseline to up to 60 months from end of therapy
|
The investigators want to demonstrate the ability of a multidisciplinary group, the ETB, to develop therapeutic strategies in participants without curative options.
They plan to enroll 35 patients to this study over 3 years.
The primary objective will be successfully met if they can develop an evolutionary based plan that differs from the participants options prior to presentation for at least 80%, or 28 of these participants.
|
Baseline to up to 60 months from end of therapy
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Christine Chung, MD, Moffitt Cancer Center
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
May 5, 2020
Primary Completion (Estimated)
March 1, 2028
Study Completion (Estimated)
March 1, 2028
Study Registration Dates
First Submitted
April 9, 2020
First Submitted That Met QC Criteria
April 9, 2020
First Posted (Actual)
April 13, 2020
Study Record Updates
Last Update Posted (Actual)
February 14, 2024
Last Update Submitted That Met QC Criteria
February 13, 2024
Last Verified
February 1, 2024
More Information
Terms related to this study
Other Study ID Numbers
- MCC-20417
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
UNDECIDED
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Incurable Disease
-
Hopital FochTerminatedIncurable DiseaseFrance
-
Cantonal Hospital of St. GallenCompleted
-
University Hospital, Strasbourg, FranceCompletedIncurable PathologiesFrance
-
Leonard ApplemanAstraZenecaCompletedAdvanced Incurable Solid MalignancyUnited States
-
Klinikum St. Georg gGmbHCompletedIncurable Cancer Diseases | Other Incurable DiseasesGermany
-
Rigshospitalet, DenmarkDanish Cancer Society; TRYG Foundation; The Danish Institute for Health Services... and other collaboratorsCompleted
-
British Columbia Cancer AgencyBC Cancer FoundationCompletedAdvanced Incurable CancersCanada
-
Astellas Pharma Global Development, Inc.CompletedTumors | Incurable Platinum Refractory Germ Cell TumorsUnited States
-
Academisch Medisch Centrum - Universiteit van Amsterdam...UMC UtrechtActive, not recruitingGastroEsophageal Cancer | Incurable DiseaseNetherlands
Clinical Trials on Evolutionary Tumor Board (ETB)
-
Jill M KolesarEli Lilly and CompanyRecruitingNon-Small Cell Lung CancerUnited States
-
University of California, San FranciscoPacific Pediatric Neuro-Oncology Consortium; The V Foundation for Cancer ResearchActive, not recruitingGlioma | Cancer | Glioblastoma | Astrocytoma | Pediatric Cancer | Pediatric Brain Tumor | Glioma of Brain | HemisphericUnited States
-
University of Wisconsin, MadisonNational Cancer Institute (NCI)Recruiting
-
Massachusetts General HospitalTrefler FoundationRecruitingCancer | Breast Cancer | Head and Neck Cancer | Schizophrenia | Lung Cancer | Bipolar Disorder | Gastrointestinal Cancer | Genitourinary Cancer | Severe Major DepressionUnited States
-
University of California, San FranciscoTranslational Genomics Research InstituteCompletedDiffuse Intrinsic Pontine Glioma (DIPG)United States
-
University of California, San FranciscoTranslational Genomics Research Institute; The Ben & Catherine Ivy FoundationCompletedAdult GlioblastomaUnited States
-
Beijing Tiantan HospitalBeijing GeneX Health Technology Co., LtdRecruitingRecurrent High Grade GliomaChina
-
Tianjin Medical University Second HospitalUnknown
-
Dartmouth-Hitchcock Medical CenterRecruiting
-
University of California, San FranciscoWashington University School of Medicine; University of Washington; Pacific Pediatric... and other collaboratorsRecruitingMedulloblastoma | Medulloblastoma, Childhood | Medulloblastoma RecurrentUnited States