A Short-term Mixed Exercise for Sarcopenic Hospitalized Aged 80+ Years

Effectiveness of a Short-term Mixed Exercise Program for Treating Sarcopenia in Hospitalized Patients Aged 80 Years and Older

Most previous clinical trials that addressed exercise for sarcopenic elderly subjects focused on community-dwelling older adults who were relatively healthy. There is a notable paucity of high-quality research investigating the effects and feasibility of exercise for hospitalized or institutionalized older people, who are generally frailer and more severe in functional impairment than those living in the community. Moreover, most reported exercise programs were of long-term duration, which typically lasted 3 to 6 months with two sessions per week. It remains unclear whether short-term exercise would be effective for treating sarcopenia. Therefore, the investigators aimed to assess the effectiveness of short-term exercise for treating sarcopenia in hospitalized older patients aged 80 years and over.

Study Overview

• Status: Completed
• Conditions: Sarcopenia
• Intervention / Treatment: Behavioral: balance training; Behavioral: resistance training; Behavioral: aerobic exercise; Behavioral: usual care

• Study Type: Interventional
• Enrollment (Actual): 121
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 80 years to 102 years (Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

1. aged ≥80 years;
2. being able to ambulate (assistance was acceptable);
3. being able to communicate and collaborate with the physiotherapist;
4. with sarcopenia defined by the AWGS criteria ;

Exclusion Criteria:

1. terminal illness;
2. uncontrolled heart failure;
3. myocardial infarction within the past three months;
4. uncontrolled respiratory failure;
5. bone fractures within the past three months;
6. acute pulmonary embolism;
7. major surgery within the past three months;
8. uncontrolled arrhythmia;
9. refusal to participate in this study.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Intervention group; a mixed exercise program including aerobic, balance, and resistance exercises that were personally tailored.	Behavioral: balance training; The training to improve balance is to work on the core muscle groups that help to maintain your posture.,and increase muscular strength.; Behavioral: resistance training; Resistance training is a form of exercise that improves muscular strength and endurance. During a resistance training workout, you move your limbs against resistance provided by your body weight, gravity, bands, weighted bars or dumbbells.; Behavioral: aerobic exercise; Aerobic exercise is any activity that gets your blood pumping and large muscle groups working. It's also known as cardiovascular activity.
Other: control group; usual care	Behavioral: usual care; received usual care

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The change of activities of daily living from the baseline to the end of the 2-week intervention	Basic activities of daily living (BADL) assessed by Barthel Index. The total score for Barthel Index ranges from 0 (worst) to 100 (best) points.	2 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The change of gait speed	Gait speed was measured using a 4-meter walking test.	2 weeks
The change of handgrip strength	Handgrip strength was measured using a digital grip dynamometer	2 weeks
The change of the score of Short Physical Performance Battery	The Short Physical Performance Battery (SPPB) is an objective assessment tool for evaluating lower extremity functioning in older persons. The total score for SPPB ranges from 0 (worst) to 12 (best) points.	2 weeks
The change of the score of Timed Up and Go test	The Timed Up and Go test (TUG) is a simple test used to measure basic functional mobility and safety with mobility. The score for the TUG is the time consumption of the whole process. The longer time consuption indicates the more worse outcome.	2 weeks

Collaborators and Investigators

• Sponsor: Yuxiang Liang
• Investigators: Study Director: ming Yang, West China Hospital; Principal Investigator: Jiaojiao Jiang, West China Hospital

Study record dates

Study Major Dates

• Study Start (Actual): October 1, 2016
• Primary Completion (Actual): December 30, 2019
• Study Completion (Actual): January 1, 2020

Study Registration Dates

• First Submitted: April 17, 2020
• First Submitted That Met QC Criteria: April 20, 2020
• First Posted (Actual): April 21, 2020

Study Record Updates

• Last Update Posted (Actual): April 22, 2020
• Last Update Submitted That Met QC Criteria: April 20, 2020
• Last Verified: April 1, 2020

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Nervous System Diseases; Neurologic Manifestations; Neuromuscular Manifestations; Pathological Conditions, Anatomical; Muscular Atrophy; Atrophy; Sarcopenia
• Other Study ID Numbers: 2019#611#

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No