Effects of Hydrolyzed Collagen and Vitamin C on Explosive Performance

Determine whether supplementation with a combined dose of 20 g of hydrolyzed collagen and 50 mg vitamin C, along with a power training exercise program, increases rate of force development (RFD) and performance in athletes

Study Overview

• Status: Completed
• Conditions: Collagen Synthesis; Rate of Force (RFD) Development
• Intervention / Treatment: Dietary supplement: Collagen and Vitamin C powder mix nutritional intervention; Other: Maximum power training exercise; Other: Maltodextrin placebo powder

• Study Type: Interventional
• Enrollment (Actual): 50
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • California
    • Davis, California, United States, 95616
      • UC Davis Functional Molecular Biology Laboratory and Human Performance Laboratory

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 30 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

1. Healthy male athletes between 18-30 years of age
2. Currently participating in sport
3. <3 musculoskeletal injuries in the past year
4. No health or dietary restriction that would be affected by the supplementation protocol

Exclusion Criteria:

1. History of more than 3 musculoskeletal injuries within the past 12 months
2. Health, dietary restriction or diet that would be affected by the supplementation protocol
3. Willing to eat similar dietary pattern the day before baseline testing and each exercise testing/intervention day

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Quadruple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Hydrolyzed collagen and Vitamin C powder mix; 20 g hydrolyzed collagen + 50 mg vitamin C (ascorbic acid) pre-packed powder diluted in 250 ml (8 oz) of water	Dietary supplement: Collagen and Vitamin C powder mix nutritional intervention; 20 g collagen + 50 mg vitamin C daily, 60 min prior to exercise; Other: Maximum power training exercise; Explosive/power-based exercise training program 3 times/week at home consisting of drop jumps, box jumps, weighted jump squats loaded in a progressive manner weekly for 3 weeks. At baseline and at the end of each of the 3 weeks, measures of explosive performance are assessed in the lab (maximal isometric squat, counter-movement jump and squat jump)
Placebo Comparator: Maltodextrin powder; 20 g maltodextrin pre-packed powder diluted in 250 ml (8 oz) of water	Other: Maximum power training exercise; Explosive/power-based exercise training program 3 times/week at home consisting of drop jumps, box jumps, weighted jump squats loaded in a progressive manner weekly for 3 weeks. At baseline and at the end of each of the 3 weeks, measures of explosive performance are assessed in the lab (maximal isometric squat, counter-movement jump and squat jump); Other: Maltodextrin placebo powder; 20 g maltodextrin placebo daily, 60 min prior to exercise

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Maximal rate of force development (RFD) of isometric squat (MIS)	Force (N) over time (msec) for the maximum slope of the first 20% of the movement	% change from baseline to week 1, week 2 and week 3
Counter-movement jump (CMJ) rate of force development (RFD)	CMJ jump performance N/s/kg	% change from baseline to week 1, week 2 and week 3
Squat jump height rate of force development (RFD)	Squat jump height performance RFD/kg	% change from baseline to week 1, week 2 and week 3

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Maximum peak force of maximal isometric squat (MIS)	Peak force (N)	% change from baseline to week 1, week 2 and week 3
Counter-movement jump (CMJ) net eccentric impulse	Jump performance max N/s/kg (Note: Eccentric is the drop down part of the CMJ)	% change from baseline to week 1, week 2 and week 3
Counter-movement jump (CMJ) net concentric impulse	Jump performance max N/s/kg (Note: Concentric is the movement upwards of the CMJ)	% change from baseline to week 1, week 2 and week 3
Leg stiffness assessment	Tendon stiffness mean per kg (N/m/kg)	% change from baseline to week 1, week 2 and week 3

Collaborators and Investigators

• Sponsor: PepsiCo Global R&D
• Investigators: Principal Investigator: Keith Baar, PhD, University of California, Davis

Study record dates

Study Major Dates

• Study Start (Actual): August 22, 2019
• Primary Completion (Actual): February 5, 2020
• Study Completion (Actual): February 5, 2020

Study Registration Dates

• First Submitted: June 12, 2020
• First Submitted That Met QC Criteria: June 16, 2020
• First Posted (Actual): June 18, 2020

Study Record Updates

• Last Update Posted (Actual): June 18, 2020
• Last Update Submitted That Met QC Criteria: June 16, 2020
• Last Verified: June 1, 2020

More Information

Terms related to this study

• Keywords: exercise; athletes; performance
• Additional Relevant MeSH Terms: Physiological Effects of Drugs; Molecular Mechanisms of Pharmacological Action; Protective Agents; Micronutrients; Vitamins; Antioxidants; Ascorbic Acid
• Other Study ID Numbers: PEP-1704

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No