- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04445116
Endeavor™ in Pediatric MS (Akili)
May 2, 2023 updated by: NYU Langone Health
A Study of Endeavor™, a Video-Game Based Cognitive Remediation, in the Pediatric Multiple Sclerosis (MS) Population
This study will examine the feasibility of using an Endeavor™ application as a treatment modality for cognitive impairments in the pediatric MS population.
Participants will be asked to undergo a hour-long baseline evaluation, followed by at-home Endeavor™ application sessions.
Subjects will complete the User Experience Feedback Form weekly on REDCap and at the end of the study.
They will undergo another hour-long follow-up evaluation at the end of the study.
Study Overview
Status
Withdrawn
Conditions
Intervention / Treatment
Detailed Description
Duration of subject participation in this study is anticipated to take 3-4 months.
After consent/assent, participants will complete an one hour-long baseline study visit in-person at the MSCCC, or through a video visit.
During this visit, participants will complete a neuropsychological evaluation and baseline study surveys and get trained on the use of the Endeavor™ video game.
Participants will then be instructed to target a completion of at-home game play 5 days a week, for a total period of 8 weeks, using their own iOS mobile device, or a study-provided device if needed, approximately 25-30 minutes each day.
Subjects will be instructed to complete the User Experience Feedback Form weekly via REDCap to assess feasibility and acceptability of Endeavor™.
At the conclusion of participation, participants will complete an hour long neuropsychological evaluation and end of study User Experience Feedback Form via REDCap (in-person at the MSCCC, or through a telehealth video visit).
Study Type
Interventional
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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New York
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New York, New York, United States, 10017
- NYU Langone Health - Ambulatory Care Center
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Contact:
- Leigh Charvet
- Phone Number: 929-455-5141
- Email: leigh.charvet@nyulangone.org
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Principal Investigator:
- Leigh Charvet
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
12 years to 22 years (Child, Adult)
Accepts Healthy Volunteers
No
Description
Inclusion Criteria:
- Age at enrollment: 12 years 0 months to 22 years 11 months
- Confirmed Diagnosis of Multiple Sclerosis with onset < 17 years and 11 months (defined by the 2013 International Pediatric MS Study Group (IPMSSG) criteria (Krupp, Tardieu, Amato, Banwell, Chitnis, Dale, Ghezzi, Hintzen, Kornberg, Pohl, Rostasy, Tenembaum, Wassmer, & Sclerosis, 2013) and the 2010 McDonald criteria (Polman et al., 2011).)
- Followed at NYU Langone Health MSCCC
- Expanded Disability Status Scale (EDSS) score of ≤3.5
Exclusion Criteria:
- Previous report of an IQ < 70
- Non-English speaking, learned English in the past three years, or learned English after the age of 12 years
- Neurological disorder (other than MS) with potential to significantly influence cognition (e.g. head injury)
- Other serious chronic or unstable medical condition (e.g., epilepsy, sickle cell disease, Type 1 diabetes)
- Not willing to comply with all study procedures
- Insufficient visual and motor ability to carry out academic and cognitive tests
- Relapse ≤ 2months prior to academic and cognitive data collection
- Steroid treatment ≤ 1 month prior to academic and cognitive data collection
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Endeavor™ Action Video Game Treatment
25 participants will fill out questionnaires and complete a neuropsychological evaluation.
During study participation, participants will target using Endeavor™ action video game to complete 25-30 minutes at-home sessions 5 days a week for a total of 8 weeks via an iOS application.
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Endeavor™ is a digital, non-drug investigational treatment that is delivered through an action video game and is designed to target cognitive deficits in adolescence and young adults with pediatric onset MS.
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Percent compliance for total at-home sessions
Time Frame: End of study (Day 60)
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Participants will be categorized as "compliant" if they interact with the mobile Endeavor™ a minimum of 3 times per week for a minimum of six of the eight weeks across the study period of 60 days.
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End of study (Day 60)
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in Fatigue in Adult participants
Time Frame: Baseline (Day 0), End of study (Day 60)
|
The Patient-Reported Outcomes Measurement Information System (PROMIS) Fatigue form will be completed by the adult MS patients (7 questions).
The PROMIS Fatigue instrument evaluate a range of self-reported symptoms that likely decrease the subjects' ability to carry out daily activities and might have an influence on cognitive function and processing speed.
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Baseline (Day 0), End of study (Day 60)
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Change in Fatigue in Pediatric participants
Time Frame: Baseline (Day 0), End of study (Day 60)
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The PROMIS Pediatric Fatigue form (23 questions) will be completed by the pediatric MS subjects enrolled in this study.
The PROMIS Fatigue instrument evaluate a range of self-reported symptoms that likely decrease the subjects' ability to carry out daily activities and might have an influence on cognitive function and processing speed.
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Baseline (Day 0), End of study (Day 60)
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Change in Depression in Participants
Time Frame: Baseline (Day 0), End of study (Day 60)
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The PROMIS Depression form (28 questions) and PROMIS Pediatric Depression form (13 questions) evaluates self-reported negative mood symptoms and social cognition.
This assessment will be completed for the adult MS patients (PROMIS Depression) and the pediatric MS subjects (PROMIS Pediatric Depression).
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Baseline (Day 0), End of study (Day 60)
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Change in Quality of life in Participants
Time Frame: Baseline (Day 0), End of study (Day 60)
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The MS Quality of Life Inventory (MSQoL) 54 Instrument is a health-related quality of life measure that combines both generic and MS-specific items and will be completed by the adult MS patients enrolled in this study.
The instrument consists of 54 self-report items and yields two summaries, a health composite summary and a mental health composite summary.
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Baseline (Day 0), End of study (Day 60)
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Change in behaviors in pediatric participants.
Time Frame: Baseline (Day 0), End of study (Day 60)
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To determine and control for depressive and other behavioral symptoms on cognitive functioning, the Behavioral Assessment Scale for Children Third Edition (BASC-III) will be administered to pediatric MS subjects in this study.
The assessments describe specific behaviors that are rated on a four-point scale of frequency, ranging from Never to Almost Always and include statements such as "My parents listen to what I say" and "I like to take risks."
This 189-item assessment will help in determining behavioral patterns.
These rating scales are performed on a computer.
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Baseline (Day 0), End of study (Day 60)
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Anticipated)
January 1, 2023
Primary Completion (Actual)
February 23, 2023
Study Completion (Actual)
February 23, 2023
Study Registration Dates
First Submitted
June 22, 2020
First Submitted That Met QC Criteria
June 22, 2020
First Posted (Actual)
June 24, 2020
Study Record Updates
Last Update Posted (Estimate)
May 4, 2023
Last Update Submitted That Met QC Criteria
May 2, 2023
Last Verified
May 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 20-00634
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
YES
IPD Plan Description
Individual participant data that underlie the results reported in this article, after deidentification (text, tables, figures, and appendices).
IPD Sharing Time Frame
Beginning 9 months and ending 36 months following article publication or as required by a condition of awards and agreements supporting the research
IPD Sharing Access Criteria
The investigator who proposed to use the data.Upon reasonable request.
equests should be directed to leigh.charvet@nyulangone.org.
To gain access, data requestors will need to sign a data access agreement.
IPD Sharing Supporting Information Type
- STUDY_PROTOCOL
- SAP
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
Yes
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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