Right Ventricular Function in End-stage Renal Disease Patients

The Impact of Different Dialysis Modalities on Right Ventricular Function in End-stage Renal Disease Patients

Sponsors

Lead Sponsor: Antalya Training and Research Hospital

Source Antalya Training and Research Hospital
Brief Summary

Right ventricular (RV) dysfunction is a major cause of heart failure and mortality in end-stage renal disease (ESRD) patients. The aim of the study was to evaluate the long-term impacts of different dialysis modalities on RV function assessed by conventional echocardiography in ESRD patients with preserved left ventricular function. The study included 83 ESRD patients grouped as follows: peritoneal dialysis (PD; n=46) and hemodialysis with brachial arterio-venous fistula (HD; n=37). Conventional echocardiography including 2D and tissue Doppler imaging was performed in all patients. Echocardiographic parameters were compared between groups.

Detailed Description

Cardiovascular diseases (CVD) are the main causes of death in patients undergoing dialysis. Right ventricular (RV) dysfunction is one of the major predictors of mortality and heart failure in this patient group. It has been shown that patients undergoing hemodialysis (HD) which is usually carried out via a surgically created arteriovenous fistula (AVF) have an increased risk for pulmonary hypertension and poorer right ventricular function compared with healthy controls . However, there are few data comparing the patients undergoing HD and peritoneal dialysis (PD), in terms of echocardiographic right ventricular function.

The aim of the present study was to elucidate the impact of both long term PD and HD therapy via brachial AVF on RV function in patients with preserved left ventricular (LV) function.

Patients undergoing dialysis were grouped as follows: 46 patients on PD and 37 patients on HD with brachial AVF. All of the study patients underwent transthoracic echocardiography. Left and right ventricular parameters were compared between two groups.

Overall Status Completed
Start Date January 1, 2019
Completion Date July 1, 2020
Primary Completion Date March 1, 2020
Study Type Observational
Primary Outcome
Measure Time Frame
Estimation of right ventricular function in end-stage renal disease patients 1 week
Enrollment 83
Condition
Intervention

Intervention Type: Diagnostic Test

Intervention Name: Transthoracic echocardiography

Description: Conventional 2-D transthoracic echocardiography was performed to all patients

Eligibility

Sampling Method: Probability Sample

Criteria:

Inclusion Criteria:

- End-stage renal disease patients on a regular dialysis program

- Being on dialysis at least 6 months

- >18 years old

Exclusion Criteria:

- Ischemic heart disease

- Left ventricular systolic dysfunction with an ejection fraction (EF) of less than 55 %

- Valvulopathy

- Left bundle branch block

- Atrial fibrilation

- Previous renal transplantation

- Chronic obstructive pulmonary disease

- Interstitial lung diseases

- Connective tissue disorders

- Chronic thromboembolic disease

- Congenital left-to-right shunt

- Primary pulmonary hypertension

Gender: All

Minimum Age: 18 Years

Maximum Age: 65 Years

Overall Official
Last Name Role Affiliation
Duygu Ersan Demirci, MD Principal Investigator Antalya Research and Training Hospital
Location
Facility: Antalya Research and Training Hospital
Location Countries

Turkey

Verification Date

August 2020

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Antalya Training and Research Hospital

Investigator Full Name: Duygu Ersan Demirci

Investigator Title: Principal investigator

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Label: hemodialysis patients

Description: end-stage renal disease patients on hemodialysis

Label: peritoneal dialysis patients

Description: end-stage renal disease patients on peritoneal dialysis

Study Design Info

Observational Model: Case-Control

Time Perspective: Cross-Sectional

Source: ClinicalTrials.gov