Sleep and Creativity

November 30, 2023 updated by: Insel Gruppe AG, University Hospital Bern

Creativity is a complex neuro-psycho-philosophical phenomenon that is difficult to define. Neurocognitive models of creativity suggest that creativity is associated with the activity of a distributed, bilateral fronto-temporal and parietal network. Therefore, a modulation of frontal activity is necessary to allow a certain degree of "controlled disinhibition", which seems to be necessary for creative thinking. In addition, a modulation of the lower parietal lobe (IPL) might allow targeting the brain regions responsible for idea generation.

This project will investigate the application of transcranial magnetic stimulation (TMS) with the intent of modulating creativity performance of healthy subjects. Resting state electroencephalography (EEG) that will be acquired pre- and post-TMS and participants' creative performance will be measured.

Perspectives include a better understanding of the differences between high- and low-creativity groups, as measured by a creativity test battery, in their response to TMS. Additional perspectives are whether there are differences in creativity performance depending on the stimulation location.

Study Overview

Status

Withdrawn

Conditions

Intervention / Treatment

Study Type

Interventional

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Switzerland
      • Berne, Switzerland, 3010
        • Department of Neurology Inselspital, Bern University Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 70 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Informed consent as documented by signature
  • Age between 18 and 70 years
  • Neurologically healthy, i.e., with no documented or present neurological disease or brain injury
  • Normal or corrected-to-normal visual acuity

Exclusion Criteria:

  • Any instable medical condition, in particular epilepsy (past or pre-sent, including seizures or febrile convulsions)
  • Any surgical intervention to the brain
  • Implanted medical devices (e.g., cochlear implants, infusion pumps, neurostimulators, pacemakers)
  • Presence of metal in the region of the head (excluding fixed dental implants such as tooth fillings or fixed dental braces)
  • Drug or alcohol abuse
  • Intake of any medication that is likely to lower seizure threshold
  • For female participants: in order to participate in the study, female patients in reproductive age need to take a pregnancy test (a stand-ard urine pregnancy test will be provided).
  • Previous enrolment in a creativity study of the same PI

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: High-creativity
Here participants are allocated to the high-creativity group. Resting state EEG will be measured pre- and post-TMS and participants' creative performance will be measured by means of a creativity test battery.
Device: Transcranial Magnetic Stimulation (TMS) over the left inferior frontal gyrus (IFG)
MagPro X100, with MagPro software version 7.1; connected to a figure-of-eight coil (MC-B70) or a circular coil (MC-125). The device is CE marked and bears an ISO 13485 certificate complying with good manufacturing practice. Continuous theta burst stimulation protocol will be applied.
Device: Transcranial Magnetic Stimulation (TMS) over the left inferior parietal lobule (IPL)
MagPro X100, with MagPro software version 7.1; connected to a figure-of-eight coil (MC-B70) or a circular coil (MC-125). The device is CE marked and bears an ISO 13485 certificate complying with good manufacturing practice. Continuous theta burst stimulation protocol will be applied.
Experimental: Low-creativity
Here participants are allocated to the low-creativity group. Resting state EEG will be measured pre- and post-TMS and participants' creative performance will be measured by means of a creativity test battery.
Device: Transcranial Magnetic Stimulation (TMS) over the left inferior frontal gyrus (IFG)
MagPro X100, with MagPro software version 7.1; connected to a figure-of-eight coil (MC-B70) or a circular coil (MC-125). The device is CE marked and bears an ISO 13485 certificate complying with good manufacturing practice. Continuous theta burst stimulation protocol will be applied.
Device: Transcranial Magnetic Stimulation (TMS) over the left inferior parietal lobule (IPL)
MagPro X100, with MagPro software version 7.1; connected to a figure-of-eight coil (MC-B70) or a circular coil (MC-125). The device is CE marked and bears an ISO 13485 certificate complying with good manufacturing practice. Continuous theta burst stimulation protocol will be applied.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in creativity performance prior- and post-TMS
Time Frame: 2.5 hours
Change in creativity performance (as expressed by a summary score of single tests from a creativity test battery) prior- and post-TMS in low- and high-creativity groups
2.5 hours

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in creativity performance prior- and post-TMS depending on stimulation location
Time Frame: 2.5 hours
Change in creativity performance (as expressed by a summary score of single tests from a creativity test battery) prior- and post-TMS depending on the stimulation location (left IFG versus left IPL)
2.5 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Insel Gruppe AG, University Hospital Bern

Investigators

  • Principal Investigator: René M. Müri, Prof. Dr., Department of Neurology Inselspital, Bern University Hospital
  • Study Chair: Claudio Bassetti, Prof. Dr., Department of Neurology Inselspital, Bern University Hospital

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

April 1, 2021

Primary Completion (Estimated)

February 1, 2022

Study Completion (Estimated)

February 1, 2022

Study Registration Dates

First Submitted

November 19, 2020

First Submitted That Met QC Criteria

November 24, 2020

First Posted (Actual)

December 2, 2020

Study Record Updates

Last Update Posted (Estimated)

December 7, 2023

Last Update Submitted That Met QC Criteria

November 30, 2023

Last Verified

November 1, 2023

More Information

Terms related to this study

Other Study ID Numbers

  • 2018-01578

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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