Effects of a Time Restricted Eating Protocol on Resistance Training Men

Effects of Time-restricted Eating and Resistance Training on Body Composition, Inflammatory Markers and Cardiometabolic Risk Factors

The study sought to investigate the effects of 16/8 time restricted eating (TRE) with windows of 16 hours of fasting and 8 hours of eating on on body composition, muscle strength, and metabolic factors during resistance training in healthy resistance trained males

Study Overview

• Status: Completed
• Conditions: Healthy; Fasting
• Intervention / Treatment: Other: Time restricted eating; Other: Normal Diet

Detailed Description

Thirty-four resistance-trained males were randomly assigned to a TRE group or to a control normal pattern group (ND) with a traditional meal pattern. The TRE group consumed 100% of the daily energy needs in an 8-hour time window: from 1PM (post meridiem) to 8:00 PM whilst the ND group consumed 100% of their daily energy needs in 3 meals between 8:00 AM (ante meridiem) and 8:00 PM. During the experimental period, training loads were similar and standardize in the two groups. partecipants were tested before and after 8 weeks of the intervention. Body composition , basal metabolism, performances indexes and blood parameters were measured. After the completition of the first two months of study, subjects were ask to volunteer to continue the intervention for 10 extra months. A total of twenty subjects from, 10 from each group (TRE or ND) continued and completed the second part of the study.

• Study Type: Interventional
• Enrollment (Actual): 34
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Italy
  • Padova, Italy, 35131
    • Nutrition and Exercise Lab, DSB, University of Padova

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 40 years (ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• continuously engaged in resistance training for at least 5 years
• at least 3 years experience in split training routines
• male

Exclusion Criteria:

• adherence to special diets
• use of nutritional supplements (except a daily multivitamin-mineral and/or protein supplement)
• use of steroids
• use of medications

Study Plan

How is the study designed?

Design Details

• Primary Purpose: BASIC_SCIENCE
• Allocation: RANDOMIZED
• Interventional Model: PARALLEL
• Masking: SINGLE

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: Time restricted eating (TRE) - two month; partecipants underwent 2 months of a TRE protocol, during which they consumed 100% of the daily energy needs in an 8-hour time window: from 1:00 PM to 8:00 PM. Body composition, muscle strength and blood parameters were measured before and after the diet intervention.	Other: Time restricted eating; TRE subjects consumed 100 % of their energy needs divided into three meals consumed at 1 p.m., 4 p.m. and 8 p.m., and fasted for the remaining 16 h per 24-h period.
ACTIVE_COMPARATOR: Normal Diet (ND) - two month; partecipants underwent 2 months of a regular diet schedule and consumed 100% of the daily energy needs in 3 meals between 8:00 AM and 8:00 PM. Body composition, muscle strength and blood parameters were measured before and after the diet intervention.	Other: Normal Diet; ND group ingested their caloric intake as three meals consumed at 8 a.m., 1 p.m. and 8 p.m.
EXPERIMENTAL: Time restricted eating (TRE) - twelve month; partecipants underwent 12 months of a TRE protocol, during which they consumed 100% of the daily energy needs in an 8-hour time window: from 1:00 PM to 8:00 PM. Body composition, muscle strength and blood parameters were measured before and after the diet intervention.	Other: Time restricted eating; TRE subjects consumed 100 % of their energy needs divided into three meals consumed at 1 p.m., 4 p.m. and 8 p.m., and fasted for the remaining 16 h per 24-h period.
ACTIVE_COMPARATOR: Normal Diet (ND) - twelve month; partecipants underwent 12 months of a regular diet schedule and consumed 100% of the daily energy needs in 3 meals between 8:00 AM and 8:00 PM. Body composition, muscle strength and blood parameters were measured before and after the diet intervention.	Other: Normal Diet; ND group ingested their caloric intake as three meals consumed at 8 a.m., 1 p.m. and 8 p.m.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Fat Mass	fat mass measured dual energy X-ray absorptiometry (DXA)	change from baseline to up to 2 months
Fat Free Mass	fat free mass measured dual energy X-ray absorptiometry (DXA)	change from baseline to up to 2 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Fat Mass	fat mass measured dual energy X-ray absorptiometry (DXA)	change from baseline to up to 12 months
Fat Free Mass	fat free mass measured dual energy X-ray absorptiometry (DXA)	change from baseline to up to 12 months
total cholesterol	total cholesterol as milligram per deciliter	change from baseline to up to 2 months
total cholesterol	total cholesterol as milligram per deciliter	change from baseline to up to 12 months
glucose	glucose as milligram per deciliter	change from baseline to up to 2 months
glucose	glucose as milligram per deciliter	change from baseline to up to 12 months
Leg muscle strength	Leg muscle strength measured via via 1-RM test	change from baseline to up to 2 months
Leg muscle strength	Leg muscle strength measured via via 1-RM test	change from baseline to up to 12 months

Collaborators and Investigators

• Sponsor: University of Padova

Publications and helpful links

General Publications

• Moro T, Tinsley G, Pacelli FQ, Marcolin G, Bianco A, Paoli A. Twelve Months of Time-restricted Eating and Resistance Training Improves Inflammatory Markers and Cardiometabolic Risk Factors. Med Sci Sports Exerc. 2021 Dec 1;53(12):2577-2585. doi: 10.1249/MSS.0000000000002738.

Study record dates

Study Major Dates

• Study Start (ACTUAL): January 1, 2014
• Primary Completion (ACTUAL): March 31, 2015
• Study Completion (ACTUAL): August 31, 2017

Study Registration Dates

• First Submitted: December 4, 2020
• First Submitted That Met QC Criteria: December 14, 2020
• First Posted (ACTUAL): December 16, 2020

Study Record Updates

• Last Update Posted (ACTUAL): December 17, 2020
• Last Update Submitted That Met QC Criteria: December 15, 2020
• Last Verified: December 1, 2020

More Information

Terms related to this study

• Keywords: inflammation; body composition; time restricted eating; fasting; resistance training
• Other Study ID Numbers: TRE-RET

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No