Impact of Time-restricted Eating on Sleep, Glucose and Insulin Sensitivity

The purpose of this research study is to see how the timing of eating impacts participants sleep and how the body responds to sugar.

Study Overview

• Status: Completed
• Conditions: Time Restricted Eating
• Intervention / Treatment: Other: Control eating; Other: Time restricted eating

Detailed Description

This research study is aimed to answer how the timing of eating impacts participants sleep and how the body responds to sugar. Participants must be healthy and between the ages of 18-65 to join . This research study will take 2 weeks of outpatient monitoring, and 2 different nights staying in the Sleep and Metabolism Lab. There are some risks to participating in this study, like hunger, skin irritation, discomfort with blood draws, and uncomfortableness while being observed. The investigators hope that this research will benefit the knowledge learned about circadian rhythms and metabolic disease and how the timing of eating affects these things.

• Study Type: Interventional
• Enrollment (Actual): 13
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Colorado
    • Fort Collins, Colorado, United States, 80523
      • Sleep and Metabolism Laboratory

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Healthy adult men and women ages 18-65
• habitual sleep duration between 7-9.25 hours
• lived at altitude for at least 3 months.

Exclusion Criteria:

• Diagnosed acute or chronic physical or psychiatric disorders;
• diagnosed sleep disorders;
• not participating in another research study concurrently which could increase risks, such as those involving medication or blood sampling;
• shiftwork in the 6 months before the study; travel more then one time zone three weeks prior to the study;
• blood donation 30 days prior to the first study visit;
• illicit drug use, prescribed medication use (excluding over the counter products) 30 days prior to the study visit;
• everyday nicotine use;
• regular consumption of over 400mg caffeine per day in the past month; and consumption of over 14 alcoholic beverages a week, or more than 4 alcoholic beverages in a single day over the past month for men and consumption of over 7 alcoholic beverages a week, or more than 3 alcoholic beverages in a single day over the past month for women.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Non-Randomized
• Interventional Model: Sequential Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Control; For the week between equipment pickup and the first overnight stay participants will maintain normal eating habits and eat across the day based on timing discussed with study staff. During this time study staff will ask participants to record meals by taking pictures and texting them to the Lab.	Other: Control eating; Participants consume a normal eating schedule across the day.
Experimental: Time restricted eating; For the week between the first and second overnight stay participants will be scheduled to eat a normal food quantity, but in a shorter period of time based on timing discussed with study staff. Typically, this will mean they will stop eating sometime in the afternoon and not eat again until breakfast the following day. During this time study staff will ask participants to record your meals by taking pictures and texting them to the Lab.	Other: Time restricted eating; For the week between the first and second overnight stay participants will be scheduled to eat a normal food quantity, but in a shorter period of time based on timing discussed with study staff. Typically, this will mean they will stop eating sometime in the afternoon and not eat again until breakfast the following day.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
24 hour Continuous Glucose Monitoring (Average glucose)	Participants will wear a continuous glucose monitor for 2 weeks. Week 1 will be compared to week 2.	2 weeks
Oral glucose tolerance test (2 hour glucose)	Participants will complete an oral glucose tolerance test on 2 occasions (end of week 1 and end of week 2)	2 weeks

Collaborators and Investigators

• Sponsor: Colorado State University

Study record dates

Study Major Dates

• Study Start (Actual): December 7, 2018
• Primary Completion (Actual): May 25, 2021
• Study Completion (Actual): May 25, 2021

Study Registration Dates

• First Submitted: February 26, 2026
• First Submitted That Met QC Criteria: February 26, 2026
• First Posted (Actual): March 3, 2026

Study Record Updates

• Last Update Posted (Actual): March 4, 2026
• Last Update Submitted That Met QC Criteria: March 2, 2026
• Last Verified: March 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Behavior; Feeding Behavior; Fasting; Intermittent Fasting
• Other Study ID Numbers: Protocol # 18-8249H

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: IPD will be shared upon reasonable request to the PI, Dr. Josiane Broussard

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No