- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04759443
Detection of Small Fiber Neuropathy Using Skin Properties
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Small fiber neuropathy, including cardiovascular diabetic neuropathy, affects millions of peoples worldwide. The neuropathy is causing disabling burning pain and dysautonomia such as dizziness with standing, brain fog, fatigue, constipation, urinary problems and cold or hot intolerance. Early and accurate diagnosis of neuropathy is essential for correct treatment. Available diagnostic methods are either invasive such as skin biopsy or available only in few specialized centers. This project addresses the limited availability of small fiber neuropathy detection.
The project utilizes utilize specialized image processing of skin pictures for the purpose to extract the statistical features that are related to loss of small fibers. The accuracy of the diagnosis verified using skin biopsies.
This approach can improve the availability of diagnosis of small fiber neuropathy.
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Contact
- Name: Peter Novak, MD
- Phone Number: 617-732-7432
- Email: pnovak2@bwh.harvard.edu
Study Locations
-
-
Massachusetts
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Boston, Massachusetts, United States, 02130
- Recruiting
- Brigham and Women's Faulkner Hospital
-
Contact:
- Peter Novak, MD
- Email: pnovak2@bwh.harvard.edu
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Patients with age 18 year or older
- Patients that sign the informed consent form to participate in this study
- Patients completed the autonomic testing with skin biopsies
Exclusion Criteria:
- Patients with significant hairs at the legs that will cover the skin
- Any dermatological disorder that can affect the skin composition
- The use of skin lotion
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Diagnostic accuracy of image processing
Time Frame: 2 years
|
The diagnostic accuracy of image processing will be evaluated by using the skin biopsy as a reference.
|
2 years
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2021P000410
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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