Breathing Performance of Healthy Young Adult

Investigation of Breathing Performance of Healthy Young Adult

The study will recruit subject of healthy adult, COPD-like patient and patient with COPD to investigate the difference of respiratory performance. We will measure the body composition, respiratory muscle force, pulmonary function and performance of voluntary cough. The muscle thickness of abdominal muscle and diaphragm, assessment of diaphragm during different breathing pattern and the muscle activation during voluntary cough will also being determined. We hypothesized that there will be a significantly different between three group on the performance of voluntary cough, and the correlation between each variable will be further investigated.

Study Overview

• Status: Completed
• Conditions: COPD; COPD-like

Detailed Description

The specific aims of the study are:

1. difference of respiratory muscle performance between three groups
2. the correlation between respiratory symptom and pulmonary functional test
3. difference of functional respiratory performance (peak cough flow of voluntary cough) between three groups
4. muscle activation of abdominal muscle and diaphragm during performing voluntary force
5. performance of diaphragm under different breathing load

• Study Type: Observational
• Enrollment (Actual): 65

Contacts and Locations

Study Locations

• Taiwan
  • Tainan, Taiwan, 704
    • National Cheng Kung University Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

1. Health subject: healthy adults with no existed respiratory condition
2. COPD-like subject: subjects with COPD-like symptoms but not reach the diagnosis criteria
3. COPD subject: subjects with diagnosed COPD

Description

1. Health subject

   Inclusion Criteria:

   • aged 20 years or above
   • currently not being diagnosis as COPD
   • less than 4 times/week of aerobic exercise

2. COPD-like subject

   Inclusion Criteria:

   • aged 20 years or above
   • currently not being diagnosis as COPD
   • presented of COPD symptoms (coughing, sputum production and dyspnea), last for 3 months and more than 2 years
   • score more than 1 on modified Medical Research Council (mMRC) or COPD Assessment Test (CAT)
3. COPD subject

Inclusion Criteria:

• aged 20 years or above
• currently being diagnosis as COPD
• haven't participated in any pulmonary rehabilitation program in the past three months

Exclusion Criteria:

• Untreated comorbidities for COPD
• Postural asymmetries (Scoliosis, length discrepancy of the lower limbs or other previous surgical history of spine)
• Chronic nonspecific lumbopelvic pain
• Gynecological or abdominal surgery in the previous year
• Pregnancy or post-delivery in the previous 6 months
• Neurological or inflammatory disorders
• Any conditions that may interfere with the data collection

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Health adult

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Peak cough flow	Peak coughing velocity of voluntary cough in liter/second	baseline

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Respiratory muscle force	MIP/MEP in cmH2O	baseline
Pulmonary function test	PEF/MVV in liter/min	baseline
Pulmonary function test	FEV1/FVC/VT in liter	baseline
Pulmonary function test	MVV rate in breaths/min	baseline
Muscle thickness during voluntary force	tRA/tEO/tIO/tTrA/tD in millimeter	baseline
Muscle activation during voluntary force	aURA/aLRA/aEO/aIOTrA/aD (all the data will be collected through surface EMG and will be presented as maximal voluntary contraction in %)	baseline
Diaphragm assessment	QB_ex/DB_ex/Sniff_ex in millimeter	baseline
Diaphragm assessment	QB_slope/DB_slope/Sniff_slope in cm/s	baseline

Collaborators and Investigators

• Sponsor: National Cheng-Kung University Hospital
• Investigators: Principal Investigator: Ching-Hsia Hung, PhD, Department of Physical Therapy, National Cheng Kung University

Publications and helpful links

General Publications

• Mesquita Montes A, Maia J, Crasto C, de Melo CA, Carvalho P, Santos R, Pereira S, Vilas-Boas JP. Abdominal muscle activity during breathing in different postures in COPD "Stage 0" and healthy subjects. Respir Physiol Neurobiol. 2017 Apr;238:14-22. doi: 10.1016/j.resp.2017.01.001. Epub 2017 Jan 7.
• Mesquita Montes A, Crasto C, de Melo CA, Santos R, Pereira S, Vilas-Boas JP. The effect of inspiratory and expiratory loads on abdominal muscle activity during breathing in subjects "at risk" for the development of chronic obstructive pulmonary disease and healthy. J Electromyogr Kinesiol. 2017 Jun;34:50-57. doi: 10.1016/j.jelekin.2017.03.005. Epub 2017 Mar 31.

Study record dates

Study Major Dates

• Study Start (Actual): May 11, 2021
• Primary Completion (Actual): May 13, 2021
• Study Completion (Actual): April 20, 2022

Study Registration Dates

• First Submitted: April 15, 2021
• First Submitted That Met QC Criteria: April 20, 2021
• First Posted (Actual): April 23, 2021

Study Record Updates

• Last Update Posted (Actual): June 10, 2022
• Last Update Submitted That Met QC Criteria: June 9, 2022
• Last Verified: June 1, 2022

More Information

Terms related to this study

• Keywords: COPD; Diaphragm; Voluntary cough; Abdominal muscle activation
• Additional Relevant MeSH Terms: Respiratory Tract Diseases; Lung Diseases; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive
• Other Study ID Numbers: A-ER-110-051

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No