Impact of Obesity on Post-operative Cognitive Dysfunction: Role of Adipose Tissue (ODCOTA)

This research aims at describing the relationship between white adipose tissue inflammation and post-operative cognitive dysfunctions.The possible link between inflammatory cytokines secretions of the white adipose tissue of a surgical wound and the arising of patient's cognitive dysfunction in the post-operative course will be investigated. The hypothesis is that obese patient's inflammation of the white adipose tissue leads to cognitive dysfunction.

Study Overview

• Status: Completed
• Conditions: Obesity; Cognitive Impairment; Post-Operative Confusion
• Intervention / Treatment: Biological: Blood sampling; Biological: white adipose tissue sampling

Detailed Description

The postoperative cognitive dysfunctions (POCD) are characterized by delirium and cognitive impairment. The delirium is defined by an acute altered attention with a fluctuating course. The post-operative cognitive impairment involves the early alteration of different functions including memory, attention and cognitive flexibility. POCD have a major impact in patient's morbidity. They are linked to the systemic inflammation induced by the surgical wound. The systemic inflammation leads to the rupture of the brain-blood barrier and to hippocampal inflammation. As hippocampus mediates the principal cognitive functions, hippocampal inflammation leads to POCD. Orthopedic and cardiac surgery are particularly concerned. Obesity is growing condition in the French population. It is linked to chronic systemic inflammation and altered cognitive functions. We think that obese people may present a susceptibility to POCD because of the pre-operative systemic inflammation.

• Study Type: Observational
• Enrollment (Actual): 115

Contacts and Locations

Study Locations

• France
  • Toulouse, France, 31059
    • Purpan University Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 99 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

prospective, monocentric study conduct in Toulouse university hospital

Description

Inclusion Criteria:

• patient about to receive a hip arthroplasty under general anesthesia, elective cardiac surgery with cardiopulmonary bypass,
• patient with a MMSE score > or = 20(/30),
• patient able to give informed consent

Exclusion Criteria:

• emergency surgery, or surgery in a septic context,
• patient with a known dementia or altered MMSE score (under 20)

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Obese patients; BMI >30kg/m2	Biological: Blood sampling; 4 tubes of 7 mL of blood will be collected; Biological: white adipose tissue sampling; At the beginning of the surgery, samples of white adipose tissue from the surgical wound will be collected.
non obese patients; BMI between 18 to 29kg/m2	Biological: Blood sampling; 4 tubes of 7 mL of blood will be collected; Biological: white adipose tissue sampling; At the beginning of the surgery, samples of white adipose tissue from the surgical wound will be collected.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Arising of POCD measured by a composite criterion	2 points Mini-Mental State Examination (MMSE) score decrease compared to the pre-operative score, and/or appearance of a delirium tracked down every day by the Confusion Assessment Method (CAM) during the hospital course.	day 5 after surgery

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Variation of inflammatory cytokine levels from patient's plasma and patient's white adipose tissue (extract from a controlled medium).	inflammatory cytokine levels will be measured in plasma and adipose tissue, and compared.	Day 0 and day 5 after surgery
Identification of a linked between inflammatory cytokine levels and the appearance of POCD.	inflammatory cytokine levels will be measured in plasma and adipose tissue, and correlated with appearance of POCD	day 5 after surgery
Peri-operative variations of the protein S100B, an autonomy scale (IADL) and a quality of life scale (EQ5D).	protein S100B levels will be measured in plasma and adipose tissue, and correlated with scores of autonomy scale (IADL) and quality of life scale (EQ5D).	day 5 after surgery

Collaborators and Investigators

• Sponsor: University Hospital, Toulouse
• Investigators: Principal Investigator: François Labaste, MD, PhD, University Hospital, Toulouse

Publications and helpful links

General Publications

• Pey V, Stephan M, Gros P, Dray C, Bounes F, Marcheix B, Minville V, Galinier A, Labaste F. Assessment of arterial whole blood redox potential during cardiopulmonary bypass. PLoS One. 2025 May 27;20(5):e0324437. doi: 10.1371/journal.pone.0324437. eCollection 2025.

Study record dates

Study Major Dates

• Study Start (Actual): September 21, 2021
• Primary Completion (Actual): September 30, 2024
• Study Completion (Actual): March 30, 2025

Study Registration Dates

• First Submitted: May 25, 2021
• First Submitted That Met QC Criteria: May 25, 2021
• First Posted (Actual): May 28, 2021

Study Record Updates

• Last Update Posted (Actual): March 9, 2026
• Last Update Submitted That Met QC Criteria: March 5, 2026
• Last Verified: March 1, 2026

More Information

Terms related to this study

• Keywords: Inflammation; Obesity; Inflammatory cytokines; Post-operative cognitive dysfunction
• Additional Relevant MeSH Terms: Mental Disorders; Pathologic Processes; Nutrition Disorders; Overnutrition; Body Weight; Neurocognitive Disorders; Cognition Disorders; Overweight; Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Signs and Symptoms; Obesity; Cognitive Dysfunction; Inflammation; Investigative Techniques; Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Blood Specimen Collection
• Other Study ID Numbers: RC31/21/0014

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No