Google Location History Following Oesophagectomy and/or Gastrectomy

March 26, 2024 updated by: Imperial College London

Google Location History (GLH) as a Health Tool to Assess Physical Activity Profiles and Patterns Following Oesophagectomy and/or Gastrectomy

Surgery is the mainstay of treatment for patients with early-disease esophageal and gastric cancer. Open surgery for oesophageal cancer commonly involves large incisions in the chest, which is associated with a high rate of respiratory complications in the postoperative period. Patients with oesophageal or gastric cancer furthermore commonly present with significant weight loss, affecting both muscle mass and muscle strength. This could further decrease the physical fitness and increase the risk for experiencing complications after treatment. Patients also report a decreased physical functioning in quality of life at least 3 years after surgery, suggesting this is a persistent deficit. Currently, no long-term data is available assessing physical activity levels in oesophageal or gastric cancer survivors. Thus, quantifying physical activity levels in these patients may identify the period in which patients' activity levels are most likely to deteriorate. Activity levels will be assessed from Google Location History from the patient's phone, providing summary of physical activity over time. This information could be used in the future to provide adequate physical therapy intervention which might improve recovery in several aspects, such as physical fitness but also respiratory function and quality of life.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Surgery is the mainstay of treatment for patients diagnosed with early-disease esophageal and gastric cancer. Open surgery for oesophageal cancer commonly involves large incisions in the chest, which is associated with a high rate of respiratory complications in the postoperative period. Several studies have shown that low physical activity levels are associated with increased risk for respiratory complication. Furthermore, patients with oesophageal or gastric cancer often present with significant weight loss, affecting both muscle mass and muscle strength. This could further decrease the physical fitness and increase the risk for experiencing complications after treatment. Moreover, open oesophagectomy involves thoracotomy, thus impairing respiratory mechanics with further deterioration in physical fitness. Patients also report a decreased physical functioning in quality of life at least 3 years after surgery, suggesting this is a persistent deficit. Currently, no long-term data is available assessing physical activity levels in oesophageal or gastric cancer survivors. Enhanced recovery programmes are evidence-based protocols aiming at early recovery after surgery with early mobilisation and physiotherapy, and have been shown to reduce respiratory complication rates. Thus, quantifying physical activity levels in these patients may identify the period in which patients' activity levels are most likely to deteriorate and whether these changes in physical activity are associated with changes in quality of life. Activity levels will be assessed from Google Location History from the patient's phone, providing summary of patterns of physical activity over time. This information could be used in the future to provide adequate physical therapy intervention which might improve recovery in several aspects, such as physical fitness but also respiratory function and quality of life.

Study Type

Observational

Enrollment (Actual)

3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United Kingdom
      • London, United Kingdom, W2 1NY
        • Imperial College London

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 90 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

There will be three cohorts, consisting of post-oesophagectomy patients, post-gastrectomy patients and a third group consisting of healthy controls.

The participants will be eligible if aged 18 years or older, up to 90 years of age.

Participants will be eligible if they can provide informed consent and can walk, run or cycle a short distance, and if they are using an Android phone.

Description

Inclusion Criteria post-oesophagectomy or -gastrectomy group:

  • is 18 years or older, and below 90 years of age, AND
  • be able to walk, run or cycle a short distance, AND
  • has been diagnosed with or already treated for oesophageal or gastric cancer
  • if already receiving treatment, any type of treatment is included, either surgical resection for early-stage disease or definitive chemotherapy for advanced disease, AND
  • use and Android phone

Inclusion Criteria healthy controls:

  • is 18 years or older, and below 90 years of age, AND
  • no previous history of upper gastrointestinal cancer, AND
  • not diagnosed with or undergoing treatment for active cancer since active cancer or cancer-related treatment might influence physical activity levels and quality of life, AND
  • be able to walk, run or cycle a short distance, AND
  • use an Android phone

Exclusion Criteria:

  • lacks capacity or is unable to provide informed consent, OR
  • below 18 years of age or over 90 years of age, OR
  • cannot walk, run or cycle a short distance, OR
  • is diagnosed with or undergoing treatment for active cancer other than oesophageal or gastric cancer, OR
  • is pregnant, OR
  • is not using an Android phone, as Google Location History data is only accessible from an Android device

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Oesophagectomy
Patients who have undergone oesophageal cancer resection.
Other: Physical activity assessment
Physical activity patterns will be obtained from google location history, using an Android phone
Gastrectomy
Patients who have undergone gastric cancer resection.
Other: Physical activity assessment
Physical activity patterns will be obtained from google location history, using an Android phone
Control group
A cohort consisting of healthy controls who have not been diagnosed with, or have undergone treatment for oesophageal or gastric cancer.
Other: Physical activity assessment
Physical activity patterns will be obtained from google location history, using an Android phone

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in physical activity pattern
Time Frame: Data will be collected up to 5 years prior to oesophageal or gastric cancer diagnosis and up to 5 years after oesophagectomy and/or gastrectomy.
The physical activity pattern will be grouped into light vs moderate vigorous activity
Data will be collected up to 5 years prior to oesophageal or gastric cancer diagnosis and up to 5 years after oesophagectomy and/or gastrectomy.

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Presence of postoperative morbidity
Time Frame: Thirty-day postoperative morbidity will be collected.
All types of postoperative morbidity will be assessed, including postoperative pulmonary complications, neurological damage, gastrointestinal symptoms, sepsis, anastomotic leak, cardiac or renal complications, urological complications, wound infection.
Thirty-day postoperative morbidity will be collected.
Health-related quality of life
Time Frame: Data will be collected at time of study recruitment, with HRQoL assessed at the time of recruitment (up to 5 years after surgery).
The health-related quality of life will be reported using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30.
Data will be collected at time of study recruitment, with HRQoL assessed at the time of recruitment (up to 5 years after surgery).

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Self-reported physical activity
Time Frame: Data will be collected at time of study recruitment, up to 5 years after surgery.
The self-reported physical activity will be estimated using the International Physical Activity Questionnaire (IPAQ)
Data will be collected at time of study recruitment, up to 5 years after surgery.
Health-related Quality of Life
Time Frame: Data will be collected at time of study recruitment, up to 5 years after surgery.
The Health-related Quality of Life will furthermore be reported using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-OG25 questionnaire.
Data will be collected at time of study recruitment, up to 5 years after surgery.
Health-related Quality of Life
Time Frame: Data will be collected at time of study recruitment, up to 5 years after surgery.
The Health-related Quality of Life will furthermore be reported using the EuroQoL 5 dimensions, 5 level (EQ-5D-5L) questionnaire.
Data will be collected at time of study recruitment, up to 5 years after surgery.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Imperial College London

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 24, 2022

Primary Completion (Actual)

December 31, 2023

Study Completion (Actual)

December 31, 2023

Study Registration Dates

First Submitted

April 21, 2021

First Submitted That Met QC Criteria

September 1, 2021

First Posted (Actual)

September 5, 2021

Study Record Updates

Last Update Posted (Actual)

March 27, 2024

Last Update Submitted That Met QC Criteria

March 26, 2024

Last Verified

March 1, 2024

More Information

Terms related to this study

Other Study ID Numbers

  • 20SM6492

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

All identifiable data will be anonymised. No data will be shared to other researchers outside the research team for the study.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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