Early Identification and Predictive Parsing for High Risk Group of Schizophrenia

Early Identification and Predictive Parsing for High Risk Group of Schizophr

An accurate identification of individuals at ultra-high risk (UHR) based on psychometric tools to prospectively identify psychosis as early as possible is required for indicated preventive intervention. The diagnostic comparability of several psychometric tools is unknown. To address the psychometric comparability of the CAARMS, SIPS and BSABS for subjects who are the immediate family and three-generation blood kinship of patients with schizophrenia. To verify the viability and reliability of the three instruments for these subjects. subjects who all are immediate family and three-generation blood kinship of patients with schizophreniawere interviewed. All the subjects were assessed for a UHR state by three psychometric tools including CAARMS, SIPS and BSABS. The psychometric diagnosis results including at risk of psychosis (UHR+), not at risk of psychosis (UHR-), and Psychosis. Demographic and clinical characteristics interviewed by these three instruments were also measured. The inter-rater agreement was assessed for evaluation of the coherence of the three scales. Transition rates of CAARMS, SIPS and BSABS for UCH+ subjects within 2 years were also recorded.There is good diagnostic agreement between the CAARMS, SIPS and BSABS towards identification of UHR subjects who are immediate family and three-generation blood kinship of patients with schizophrenia. Also, these three instruments are reliable and valid for assessing and detecting at risk mental states in these subjects.

Study Overview

• Status: Completed
• Conditions: High Risk Group of Schizophrenia
• Intervention / Treatment: Diagnostic test: CAARMS;SIPS; BSABS

• Study Type: Observational
• Enrollment (Actual): 189

Contacts and Locations

Study Locations

• China
  • Hubei
    • Wuhan, Hubei, China, 430022
      • Dept. of Psychological Rehabilitation, Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

All are immediate family and three-generation blood kinship of patients with schizophrenia diagnosed in Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology.

Subjects are recruited from Wuhan Mental Health Center who can be contacted by telephone or an internet homepage.

Description

Inclusion Criteria:

• all are immediate family and three-generation blood kinship of patients with schizophrenia

Exclusion Criteria:

-

Study Plan

How is the study designed?

Design Details

• Observational Models: Family-Based
• Time Perspectives: Prospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The overall agreement percent	diagnostic comparison of CAARMS and SIPS, SIPS and BSABS, CAARMS and BSABS.	2 years
the inter-rater reliability	Inter-rater correlation (ICC) coefficients of CAARMS, SIPS and BSABS subscales.	2 years
the transition rates of UHR+ to psychosis within 2 years	Transition rates of CAARMS, SIPS and BSABS for UCH+ subjects within 2 years follow-up.	2 years

Collaborators and Investigators

• Sponsor: Wuhan Mental Health Centre
• Collaborators: Health Commission of Hubei Province
• Investigators: Principal Investigator: Peng Wang, Master, Dept. of Psychological Rehabilitation, Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology

Study record dates

Study Major Dates

• Study Start (Actual): May 1, 2017
• Primary Completion (Actual): January 1, 2019
• Study Completion (Actual): April 1, 2021

Study Registration Dates

• First Submitted: August 31, 2021
• First Submitted That Met QC Criteria: September 6, 2021
• First Posted (Actual): September 13, 2021

Study Record Updates

• Last Update Posted (Actual): September 13, 2021
• Last Update Submitted That Met QC Criteria: September 6, 2021
• Last Verified: August 1, 2021

More Information

Terms related to this study

• Keywords: Psychosis; UHR; CAARMS;SIPS; BSABS
• Additional Relevant MeSH Terms: Mental Disorders; Schizophrenia Spectrum and Other Psychotic Disorders; Schizophrenia
• Other Study ID Numbers: ky2018.45

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: Undecided

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No