Colorectal Cancer Prehabilitation in Changi General Hospital

Cancer prehabilitation typically involves multiple pre-op visits. The investigators aim to assess the impact of their novel model, a "one-stop "service by a small, "levelled-up" core team on newly diagnosed colorectal cancer patients planned for surgery.

Study Overview

• Status: Completed
• Conditions: Colorectal Cancer
• Intervention / Treatment: Other: Colorectal Cancer Prehabilitation Programme

Detailed Description

Objective Cancer prehabilitation typically involves multiple pre-op visits. The investigators aim to assess the impact of their novel model, a "one-stop "service by a small, "levelled-up" core team on newly diagnosed colorectal cancer patients planned for surgery.

Design This is a before-after trial in a tertiary public hospital in Singapore, involving all newly diagnosed colorectal cancer patients planned for surgery who are referred to the Cancer Prehabilitation Program. The primary outcome measure is the 6-minute-walk-test. Others include physical, psychological, quality-of-life and post-operative measures, and patient-satisfaction-surveys, taken at baseline, pre-operatively (post-prehabilitation), and 3-months-post-operatively.

Keywords: Colorectal; Cancer Prehabilitation; Novel; Model of Care

• Study Type: Interventional
• Enrollment (Actual): 59
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Singapore
  • Singapore, Singapore, 529889
    • Changi General Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 21 years to 99 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

1. All newly diagnosed colorectal cancer patients planned for surgery in Changi General Hospital, Singapore

Exclusion Criteria:

1. Patients' refusal to participate

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Supportive Care
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: Colorectal Cancer Prehabilitation Program; This is a before-after trial. The same group of participants will have a series of outcome measures taken at baseline, which will then be compared to these same outcome measures when repeated after undergoing prehabilitation and at 3 months' post-operatively	Other: Colorectal Cancer Prehabilitation Programme; Assessment and Interventions involving the Prehabilitative domains of medical optimisation, exercise prescription, nutrition and mental health optimisation

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
6-minute-walk-test	Distance walked in 6 minutes under standardised conditions	Baseline
6-minute-walk-test	Distance walked in 6 minutes under standardised conditions	Pre-Operatively (after prehabilitation)
6-minute-walk-test	Distance walked in 6 minutes under standardised conditions	Post-Operatively (3 months)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
30-second-sit-to-stand-test	Number of repetitions of sit-to-stand within 30 seconds	Baseline
30-second-sit-to-stand-test	Number of repetitions of sit-to-stand within 30 seconds	Pre-Operatively (after prehabilitation)
30-second-sit-to-stand-test	Number of repetitions of sit-to-stand within 30 seconds	Post-Operatively (3 months)
Hospital Anxiety and Depression Scale	Divided into Anxiety (0-21 points) and Depression scale (0-21 points), the higher the worser	Baseline
Hospital Anxiety and Depression Scale	Divided into Anxiety (0-21 points) and Depression scale (0-21 points), the higher the worser	Pre-Operatively (after prehabilitation)
Hospital Anxiety and Depression Scale	Divided into Anxiety (0-21 points) and Depression scale (0-21 points), the higher the worser	Post-Operatively (3 months)
EuroQol- 5 Dimension	Health Score (visual analogue scale from 0-100), the higher the better	Baseline
EuroQol- 5 Dimension	Health Score (visual analogue scale from 0-100), the higher the better	Post-Operatively (3 months)
Post-Operative Hospital Length of Stay	Post-Operative Hospital Length of Stay	From Date of Admission for Surgery till Date of Discharge, assessed up to 100 weeks
30-Day Post-Operative Major Complications	30-Day Post-Operative Major Complications	From Surgery till 30 Days Post-op
30-Day Post-Operative Readmission Rates	30-Day Post-Operative Readmission Rates	From Surgery till 30 Days Post-op
30-Day Post-Operative Mortality	30-Day Post-Operative Mortality	From Surgery till 30 Days Post-op
Patient Satisfaction Survey	Patient Satisfaction Survey	Pre-Operatively (after prehabilitation)
Patient Satisfaction Survey	Patient Satisfaction Survey	Post-Operatively (3 months)

Collaborators and Investigators

• Sponsor: Changi General Hospital

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2020
• Primary Completion (Actual): June 30, 2021
• Study Completion (Actual): June 30, 2021

Study Registration Dates

• First Submitted: November 30, 2021
• First Submitted That Met QC Criteria: December 13, 2021
• First Posted (Actual): December 27, 2021

Study Record Updates

• Last Update Posted (Actual): December 27, 2021
• Last Update Submitted That Met QC Criteria: December 13, 2021
• Last Verified: December 1, 2021

More Information

Terms related to this study

• Keywords: Novel; Colorectal; Cancer Prehabilitation; Model of Care
• Additional Relevant MeSH Terms: Digestive System Diseases; Neoplasms; Neoplasms by Site; Gastrointestinal Neoplasms; Digestive System Neoplasms; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Intestinal Neoplasms; Rectal Diseases; Colorectal Neoplasms
• Other Study ID Numbers: CIRB Ref No.:2020/2063

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No