- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05365607
NightWare and Cardiovascular Health in Adults With PTSD
NightWare Therapeutic Platform for Improving Cardiovascular Health in Adults With Nightmares Associated With PTSD
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Posttraumatic stress disorder (PTSD) is linked to accelerated aging and is associated with increased risk of early-onset cardiovascular disease (CVD) in both men and women. The pathophysiological link between PTSD and CVD is complex and multi-factorial that likely involves premature vascular aging (i.e., large elastic arterial stiffening and vascular endothelial dysfunction) and autonomic dysfunction (e.g., reduced cardiovagal baroreflex sensitivity [cBRS] and heart rate variability [HRV]), along with other mechanisms. Vascular aging and autonomic dysfunction are key antecedents in the development of CVD and individuals with PTSD have greater arterial stiffening, endothelial dysfunction and reductions in cBRS and HRV compared to those without PTSD. The mechanisms by which PTSD contributes to greater vascular and autonomic dysfunction are not completely understood. Sleep is important for cellular and tissue repair, free radical detoxification and reducing oxidative stress and inflammation. Sleep disturbance is a hallmark symptom of PTSD and is associated with biomarkers of vascular aging, autonomic dysfunction and increased risk of CVD. Nightmares, a central feature of PTSD associated-sleep disturbance, are a debilitating symptom that can lead to insomnia or sleep deprivation, daytime sleepiness or fatigue, mood disturbances, cognitive impairments, behavioral problems, or other sequela, that ultimately causes clinically significant distress and impairment in social, occupational and physiological function, as well as increased CVD risk. As such, therapeutic strategies and interventions aimed at reducing nightmare-associated sleep disturbances in individuals with PTSD are clinically important for improving sleep quality, cardiovascular health and risk for future age-associated CVD.
Various psychotherapeutic (e.g., imagery rehearsal therapy [IRT]) and pharmacological (e.g., prazosin) interventions are available for treatment of nightmares associated with PTSD. However, the evidence for their efficacy for addressing sleep disturbances is inconsistent, particularly with pharmaceuticals, and implementation barriers and poor adherence exist with psychotherapy. As such, novel alternative approaches, including the use of digital medicine such as app-based and digital platforms are being developed to improve treatment delivery. NightWare™ digital therapeutic system is one such novel platform that was recently granted Breakthrough Device designation by the FDA for the treatment of nightmares in adults with PTSD. NightWare uses a proprietary application on the Apple Watch® to collect biometric data (i.e., heart rate [HR] and body movement) to learn sleep patterns to create a stress Index. When an individual exceeds this index due to entering a nightmare, NightWare intervenes by sending vibrotactile feedback to the Apple Watch, arousing the individual and interrupting the nightmare without waking or disrupting sleep. Through machine learning, NightWare continually refines its model and knowledge of the person's response, consequently leading to fewer nightmare associated awakenings. In unpublished preliminary studies, NightWare was shown to be safe (no change in suicide risk or daytime sleepiness) and a tendency to have greater improvement in objective measures of sleep quality (i.e., Pittsburgh Sleep Quality Index [PSQI] and amendment for PTSD [PSQI-A]) compared to sham (NightWare but intervention disabled, i.e., no vibration). Whether NightWare improves cardiovascular health in adults with PTSD-related nightmares has yet to be studied.
Accordingly, the investigators are proposing a randomized, double-blind, placebo (i.e., sham intervention) controlled parallel pilot study that will provide the first clinical evidence for the efficacy of the NightWare digital therapeutic system to improve cardiovascular health outcomes in adults with PTSD-related nightmares.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Kerrie Moreau, PhD
- Phone Number: 303-724-1914
- Email: kerrie.moreau@cuanschutz.edu
Study Locations
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-
Colorado
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Aurora, Colorado, United States, 80045
- Recruiting
- University of Colorado Anschutz Medical Campus
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Contact:
- Kerrie L Moreau, PhD
- Phone Number: 303-724-1914
- Email: kerrie.moreau@ucdenver.edu
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Denver, Colorado, United States, 80045
- Recruiting
- University of Colorado CCTSI CTRC
-
Contact:
- Kerrie Moreau, PhD
- Phone Number: 303-724-1914
- Email: kerrie.moreau@ucdenver.edu
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Diagnosis of PTSD via American Psychiatric Association PTSD diagnostic criteria in the fifth edition of its Diagnostic and Statistical Manual of Mental Disorders (DSM-5).
- Self-report having repetitive nightmares contributing to disrupted sleep
- age >22 years (rationale is because the device has only been used in adults in 22 years and older);
- resting blood pressure (BP, <160/100 mmHg);
- fasted glucose <126 mg/d;
- non-smokers;
- no use of vitamin supplements or anti-inflammatory medications, or willing to stop 1 month prior to the vascular visit;
- Pittsburgh Sleep Quality Index (PSQI) score 6 or higher;
- Epworth Sleepiness Scale (ESS): Question #8 score above "0" will prompt an additional question: Does individual drive ("get behind the wheel") when they are drowsy? The answer must be "No" to be enrolled in the study due to safety concerns;
- Wireless Internet and two power outlets where they sleep;
- Willingness not to use any other application which collects heart rate data on the phone and watch that is used for NightWare.
Exclusion Criteria:
- uncontrolled hypertension;
- current or preexisting CVD or cancers (with the exception of past skin cancers) or active infection;
- diabetes;
- thyroid dysfunction, defined as an ultrasensitive TSH <0.5 or >5.0 mU/L; volunteers with abnormal TSH values will be re-considered for participation in the study after follow-up evaluation by the PCP with initiation or adjustment of thyroid hormone replacement; or other problems that would interfere with participation in the study;
- pregnancy or currently breast feeding;
- current use (or within previous 6 months) of hormone therapy in postmenopausal women;
- current substance (including marijuana) or alcohol use disorder (past 12 months) per the SCID-5 (see methods of Research Strategy). Adults with past substance or alcohol use disorders will be allowed to participate.
- Prazosin use; however, participant may be included if tapered by prescribing provider. Taper must be completed and individual must be off prazosin for 2 days prior to enrollment;
- Participants will be excluded if they report elevated acute risk for suicidal self-directed violence warranting immediate intervention (e.g., suicidal ideation with intent, evaluated by the Columbia-Suicide Severity Rating Scale [C-SSRS]).
- Current use of varenicline, beta-blockers (unless ophthalmic solutions), or non-dihydropyridines;
- Shift workers (due to circadian rhythm disruption);
- Moderate or Severe obstructive sleep apnea (either diagnosed or determined during screening with the WatchPat [AHI≥15];
- Diagnosis of narcolepsy;
- Known sleepwalking;
16) Acting out of dreams prior to PTSD trauma; 17) Diagnosis or suspicion of dementia
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: NightWare
In individuals randomized to the active condition, when the stress index is reached during sleep, NightWare will intervene with varying degrees of vibratory stimulation to the watch over a variable length of time to arouse the person out of the nightmare without awaking.
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A wearable digital therapeutic platform consisting of an Apple Watch and iPhone pre-provisioned with Nightware intervention app that will deliver a mild vibration to the watch after detecting individual having a nightmare based on Nightware proprietary algorithm, arousing the individual and disrupting nightmare without awakening.
|
Sham Comparator: Sham NightWare
In individuals randomized to the sham condition, the NightWare intervention will not be enabled.
|
NightWare device will not deliver an intervention (i.e., no vibration)
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in large elastic artery stiffness -carotid artery
Time Frame: Measured before and after 6 weeks of NightWare and sham conditions
|
Carotid artery compliance using carotid artery ultrasound
|
Measured before and after 6 weeks of NightWare and sham conditions
|
Change in endothelial function
Time Frame: Measured before and after 6 weeks of NightWare and sham conditions
|
Brachial artery flow-mediated dilation (FMD) using ultrasound
|
Measured before and after 6 weeks of NightWare and sham conditions
|
Change in 1utonomic function - BRS
Time Frame: Measured before and after 6 weeks of NightWare and sham conditions
|
Cardiovagal baroreflex sensitivity (cBRS)
|
Measured before and after 6 weeks of NightWare and sham conditions
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in large elastic artery stiffness
Time Frame: Measured before and after 6 weeks of NightWare and sham conditions
|
Carotid-femoral pulse wave velocity (PWV)
|
Measured before and after 6 weeks of NightWare and sham conditions
|
Change in autonomic function - HRV
Time Frame: Measured before and after 6 weeks of NightWare and sham conditions
|
Heart rate variability
|
Measured before and after 6 weeks of NightWare and sham conditions
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in PSQI
Time Frame: Measured before and after 6 weeks of NightWare and sham conditions
|
sleep questionnaire
|
Measured before and after 6 weeks of NightWare and sham conditions
|
Change in PSQI-A
Time Frame: Measured before and after 6 weeks of NightWare and sham conditions
|
sleep questionnaire
|
Measured before and after 6 weeks of NightWare and sham conditions
|
Change in Epworth sleepiness scale (ESS)
Time Frame: Measured before and after 6 weeks of NightWare and sham conditions
|
sleep questionnaire
|
Measured before and after 6 weeks of NightWare and sham conditions
|
Change in CESD
Time Frame: Measured before and after 6 weeks of NightWare and sham conditions
|
Depression questionnaire
|
Measured before and after 6 weeks of NightWare and sham conditions
|
Change in SF-36
Time Frame: Measured before and after 6 weeks of NightWare and sham conditions
|
Perceived psychosocial and health functioning questionnaire
|
Measured before and after 6 weeks of NightWare and sham conditions
|
Change in PCL-5
Time Frame: Measured before and after 6 weeks of NightWare and sham conditions
|
Presence and severity of PTSD symptoms questionnaire
|
Measured before and after 6 weeks of NightWare and sham conditions
|
Change in Nightmare disorder index
Time Frame: Measured before and after 6 weeks of NightWare and sham conditions
|
NDI questionnaire
|
Measured before and after 6 weeks of NightWare and sham conditions
|
Change in CSSR-S
Time Frame: Measured before and after 6 weeks of NightWare and sham conditions
|
Suicide risk assessment
|
Measured before and after 6 weeks of NightWare and sham conditions
|
Change in Norepinephrine
Time Frame: Measured before and after 6 weeks of NightWare and sham conditions
|
Marker of sympathetic activity
|
Measured before and after 6 weeks of NightWare and sham conditions
|
Change in Oxidized LDL
Time Frame: Measured before and after 6 weeks of NightWare and sham conditions
|
Marker of oxidative stress
|
Measured before and after 6 weeks of NightWare and sham conditions
|
Change in Total antioxidant status
Time Frame: Measured before and after 6 weeks of NightWare and sham conditions
|
Marker of oxidative stress
|
Measured before and after 6 weeks of NightWare and sham conditions
|
Change in Interleukin-6
Time Frame: Measured before and after 6 weeks of NightWare and sham conditions
|
Marker of inflammation
|
Measured before and after 6 weeks of NightWare and sham conditions
|
Change in C-Reactive Protein
Time Frame: Measured before and after 6 weeks of NightWare and sham conditions
|
Marker of inflammation
|
Measured before and after 6 weeks of NightWare and sham conditions
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Kerrie Moreau, PhD, University of Colorado - Anschutz Medical Campus
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 21-5027
- R21AG075544 (U.S. NIH Grant/Contract)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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