Study of Thyroid Status in Patients With IBD

September 14, 2022 updated by: Nesreen Hassan Mansour Ali, Assiut University

Study of Thyroid State in Patients With Inflammatory Bowel Diseases

. The aim of the present study is to study thyroid state in patients with IBD

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

All patients were subjected to history taking and physical examination with emphasis on history of autoimmune disease, extraintestinal manifestations of IBD, neck examination for goiter, symptoms and signs of thyroid dysfunction.

b) Laboratory investigations: Thyroid function test (include T3-T4- TSH)

  • ESR - CRP - thyroid antibodies: (Anti TPO -Anti Thyroglobulin)

    c)-Imaging:

  • Neck U/S on thyroid gland to identify patients with ultrasonographic evidence of autoimmune thyroiditis (diffuse hypoechogenicity or heterogenicity echotexture or both) and to detect thyroid nodularity.

d ) Endoscopic findings regarding diagnosis of IBD confirmed by histopathological examination

Study Type

Observational

Enrollment (Anticipated)

90

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • Egypt
      • Assiut, Egypt
        • Assiut University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • ADULT
  • OLDER_ADULT
  • CHILD

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

patients with IBD admitted at Assiut University Hospital, Al Rajhi Liver Hospital or attending IBD outpatient clinic.

a. Inclusion criteria: All patients with IBD Exclusion criteria: patients with

  • Thyroid disease
  • Acute or chronic kidney
  • Acute or Chronic Liver Disease. Active Lupus -
  • Malignancy
  • patients taking medications that affect thyroid function as rifampin, amiodarone

Description

Inclusion Criteria: All patients with IBD

-

Exclusion Criteria:

  • patients with
  • Thyroid disease
  • Acute or chronic kidney
  • Acute or Chronic Liver Disease. Active Lupus -
  • Malignancy
  • patients taking medications that affect thyroid function as rifampin, amiodarone …..

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Patients with IBD

All patients were subjected to history taking and physical examination with emphasis on history of autoimmune disease, extraintestinal manifestations of IBD, neck examination for goiter, symptoms and signs of thyroid dysfunction.

b) Laboratory investigations: Thyroid function test (include T3-T4- TSH)

  • ESR - CRP - thyroid antibodies: (Anti TPO -Anti Thyroglobulin)

    c)-Imaging:

  • Neck U/S on thyroid gland to identify patients with ultrasonographic evidence of autoimmune thyroiditis (diffuse hypoechogenicity or heterogenicity echotexture or both) and to detect thyroid nodularity.

d ) Endoscopic findings regarding diagnosis of IBD confirmed by histopathological examination
Diagnostic test: Thyroid tests
Thyroid function test TSH ,T3,T4 Thyroid antibody test anti TPO,antithyroglobulin
Other Names:
  • Thyroid function test and thyroid antibodies
Healty individuals as a control group

All patients were subjected to history taking and physical examination with emphasis on history of autoimmune disease, extraintestinal manifestations of IBD, neck examination for goiter, symptoms and signs of thyroid dysfunction.

b) Laboratory investigations: Thyroid function test (include T3-T4- TSH)

  • ESR - CRP - thyroid antibodies: (Anti TPO -Anti Thyroglobulin)

    c)-Imaging:

  • Neck U/S on thyroid gland to identify patients with ultrasonographic evidence of autoimmune thyroiditis (diffuse hypoechogenicity or heterogenicity echotexture or both) and to detect thyroid nodularity.
Diagnostic test: Thyroid tests
Thyroid function test TSH ,T3,T4 Thyroid antibody test anti TPO,antithyroglobulin
Other Names:
  • Thyroid function test and thyroid antibodies

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Percentage of thyroid disorders in patients with IBD
Time Frame: 1 year
By use of Thyroid function test (include T3-T4- TSH), thyroid antibodies and thyroid sonography
1 year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Assiut University

Investigators

  • Principal Investigator: Abo zaid Ali, assistant prof, Assiut University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ANTICIPATED)

December 1, 2022

Primary Completion (ANTICIPATED)

December 1, 2024

Study Completion (ANTICIPATED)

December 1, 2024

Study Registration Dates

First Submitted

May 20, 2022

First Submitted That Met QC Criteria

September 14, 2022

First Posted (ACTUAL)

September 15, 2022

Study Record Updates

Last Update Posted (ACTUAL)

September 15, 2022

Last Update Submitted That Met QC Criteria

September 14, 2022

Last Verified

September 1, 2022

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • thyroid state in IBD patients

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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