Study of Thyroid Status in Patients With IBD
Study of Thyroid State in Patients With Inflammatory Bowel Diseases
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
All patients were subjected to history taking and physical examination with emphasis on history of autoimmune disease, extraintestinal manifestations of IBD, neck examination for goiter, symptoms and signs of thyroid dysfunction.
b) Laboratory investigations: Thyroid function test (include T3-T4- TSH)
ESR - CRP - thyroid antibodies: (Anti TPO -Anti Thyroglobulin)
c)-Imaging:
- Neck U/S on thyroid gland to identify patients with ultrasonographic evidence of autoimmune thyroiditis (diffuse hypoechogenicity or heterogenicity echotexture or both) and to detect thyroid nodularity.
d ) Endoscopic findings regarding diagnosis of IBD confirmed by histopathological examination
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Hassan, Resident
- Phone Number: +201144971296
- Email: nisreenhassan6@gmail.com
Study Contact Backup
- Name: Abu Bakr Elisily, professor
- Phone Number: +201006564000
- Email: fatmaelosily@yahoo.com
Study Locations
-
-
-
Assiut, Egypt
- Assiut University
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- ADULT
- OLDER_ADULT
- CHILD
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
patients with IBD admitted at Assiut University Hospital, Al Rajhi Liver Hospital or attending IBD outpatient clinic.
a. Inclusion criteria: All patients with IBD Exclusion criteria: patients with
- Thyroid disease
- Acute or chronic kidney
- Acute or Chronic Liver Disease. Active Lupus -
- Malignancy
- patients taking medications that affect thyroid function as rifampin, amiodarone
Description
Inclusion Criteria: All patients with IBD
-
Exclusion Criteria:
- patients with
- Thyroid disease
- Acute or chronic kidney
- Acute or Chronic Liver Disease. Active Lupus -
- Malignancy
- patients taking medications that affect thyroid function as rifampin, amiodarone …..
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
|---|---|
|
Patients with IBD
All patients were subjected to history taking and physical examination with emphasis on history of autoimmune disease, extraintestinal manifestations of IBD, neck examination for goiter, symptoms and signs of thyroid dysfunction. b) Laboratory investigations: Thyroid function test (include T3-T4- TSH)
d ) Endoscopic findings regarding diagnosis of IBD confirmed by histopathological examination |
Thyroid function test TSH ,T3,T4 Thyroid antibody test anti TPO,antithyroglobulin
Other Names:
|
|
Healty individuals as a control group
All patients were subjected to history taking and physical examination with emphasis on history of autoimmune disease, extraintestinal manifestations of IBD, neck examination for goiter, symptoms and signs of thyroid dysfunction. b) Laboratory investigations: Thyroid function test (include T3-T4- TSH)
|
Thyroid function test TSH ,T3,T4 Thyroid antibody test anti TPO,antithyroglobulin
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Percentage of thyroid disorders in patients with IBD
Time Frame: 1 year
|
By use of Thyroid function test (include T3-T4- TSH), thyroid antibodies and thyroid sonography
|
1 year
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Abo zaid Ali, assistant prof, Assiut University
Publications and helpful links
Helpful Links
- nflammatory bowel disease severity and activity are correlated to thyroid gland nodularity, chronic nonthyroidal illness, and thyroid autoantibodies but not thyroid dysfunction
- Medical records of patients with ulcerative colitis (n= 858), Crohn's disease (n= 378) and coeliac disease (n = 148) were examined to determine the prevalence of associated autoimmune disorders.
- The prevalence of hyper- and hypothyroidism in patients with ulcerative colitis
- Two cases of coexisting ulcerative colitis and hyperthyroidism are discussed
- Role of autoantibodies in the pathogenesis and association of endocrine autoimmune disorders
- Autoimmune thyroid disease (Graves' disease and hashimoto's thyroiditis) in two patients with Crohn's disease: case reports and literature review
- Simultaneous occurrence of inflammatory bowel disease and thyroid disease
- Coexistence of Addison's disease, ulcerative colitis, hypothyroidism and pernicious anemia
Study record dates
Study Major Dates
Study Start (ANTICIPATED)
Primary Completion (ANTICIPATED)
Study Completion (ANTICIPATED)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ACTUAL)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- thyroid state in IBD patients
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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