Hibiscus Sabdariffa Extract Effect on Neuromuscular Performance (RECUPERA-T)

Hibiscus Sabdariffa Extract Effect on Neuromuscular Performance After Intense Resistance Exercise: a Randomized, Placebo-controlled, Crossover Study

Exercise-induced muscle damage (EIMD) is a transient problem that athletes face after performing more intense and/or prolonged exercise than they are used to. EIMD is accompanied by an increase in the production of reactive oxygen species and a decrease in the antioxidant capacity of the organism. This phenomenon decreases the performance capacity of athletes due to impaired muscle strength and range of motion. Among the strategies to reduce EIMD, the use of nutritional strategies rich in antioxidants such as polyphenols stands out. In this sense, the extract of Hibiscus sabdariffa is particularly rich in polyphenolic antioxidants, among which anthocyanins stand out. Previous studies have concluded that the administration of an extract of Hibiscus sabdariffa can prevent overtraining syndrome by reducing the levels of oxidizing agents and increasing the body's antioxidant defenses. However, despite the fact that Hibiscus sabdariffa extract has been shown to be safe for humans to ingest and have various health benefits, to our knowledge, no studies have evaluated its ability to minimize neuromuscular performance impairment that occurs after performing an intense session of strength training. Based on previous evidence, we hypothesize that supplementation with an extract of Hibiscus sabdariffa will improve neuromuscular performance after performing intense resistance exercise in young (18-35 years) and trained adults, with at least 1 year of experience training. strength. The design of this study is crossover, randomized and placebo controlled, where each individual will act as her own control. The neuromuscular performance parameters to be evaluated will be: i) explosive strength - main variable, in terms of countermovement jump height (CMJ); ii) the maximum dynamic force; and iii) the ability to change direction, all of them 24h and 72h after a high-intensity strength training session. If our hypothesis is confirmed, the results of our study would not only have an impact at a scientific level but also at a commercial level through the development of supplements and/or functional foods.

Study Overview

• Status: Recruiting
• Conditions: Neuromuscular Performance
• Intervention / Treatment: Dietary supplement: Hibiscus sabdariffa extract

• Study Type: Interventional
• Enrollment (Anticipated): 25
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Francisco J Osuna-Prieto, PhD; Phone Number: +34 618117577; Email: fjosunaprieto@ugr.es

Study Locations

• Spain
  • Granada, Spain, 18007
    • Recruiting
    • Instituto Mixto Universitario Deporte y Salud (IMUDS)
    • Contact: Francisco Javier O Osuna-Prieto, PhD.; Phone Number: +34 618117577; Email: fjosunaprieto@ugr.es
    • Principal Investigator: Francisco J. Osuna-Prieto, PhD.
    • Principal Investigator: Jonatan. R. Ruiz, PhD.
    • Sub-Investigator: Juan José Martín-Olmedo
    • Sub-Investigator: Antonio Segura-Carretero, Professor
  • Granada, Spain, 18071
    • Recruiting
    • Facultad de Ciencias del Deporte
    • Contact: Francisco J O Osuna-Prieto, PhD; Phone Number: +34 618117577; Email: fjosunaprieto@ugr.es

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 35 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Age: 18-35 years.
• Body mass index: 18.5-30 kg/m2
• Be able to understand the instructions, objectives, and protocol of the study.
• Trained in some force sports discipline ≥1 year prior to the study and accustomed to carrying out the exercises of the evaluation protocol.

Exclusion Criteria:

• History of a major adverse cardiovascular event, renal failure, cirrhosis, eating disorder, polycystic ovarian syndrome, weight control surgery, type 2 diabetes mellitus, or HIV/AIDS.
• Any chronic pathology in which the intake of nutritional supplements is not recommended.
• Any condition that, in the investigator's judgment, impairs the ability to participate in the study or represents a personal risk to the participant.
• Use of medications that may affect the results of the study.
• Unstable body weight for 3 months prior to study start (>4 kg weight gain or loss)
• Routine use of teas/infusions/supplements rich in polyphenols.
• Pregnancy and lactation.
• Active tobacco or illicit drug use or history of treatment for alcohol abuse.
• To be on a special diet or prescribed for other reasons (eg celiac disease).

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Triple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo; Microcrystalline cellulose	Dietary supplement: Hibiscus sabdariffa extract; Daily supplementation with 520 mg of Hibiscus sabdariffa extract for 10 days.
Experimental: Hibiscus sabdariffa extract; 520 mg of Hibiscus sabdariffa extract	Dietary supplement: Hibiscus sabdariffa extract; Daily supplementation with 520 mg of Hibiscus sabdariffa extract for 10 days.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Explosive strength	It will be measured through the height of the countermovement jump (CMJ)	1 day (24h) after a bout of an intense resistance exercise
Maximal dynamic force	It will be measured by means of a CMJ with a load	1 day (24h) after a bout of an intense resistance exercise
Ability to change direction	It will be measured by means of a CMJ with a load	1 day (24h) after a bout of an intense resistance exercise

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Explosive strength	It will be measured through the height of the countermovement jump (CMJ)	3 days (72h) after a bout of an intense resistance exercise
Maximal dynamic force	It will be measured by means of a CMJ with a load	3 days (72h) after a bout of an intense resistance exercise
Ability to change direction	It will be measured by repeated sprint T-test	3 days (72h) after a bout of an intense resistance exercise

Collaborators and Investigators

• Sponsor: Universidad de Granada

Study record dates

Study Major Dates

• Study Start (Actual): January 23, 2023
• Primary Completion (Anticipated): April 1, 2023
• Study Completion (Anticipated): June 1, 2023

Study Registration Dates

• First Submitted: November 28, 2022
• First Submitted That Met QC Criteria: December 7, 2022
• First Posted (Actual): December 16, 2022

Study Record Updates

• Last Update Posted (Estimate): January 26, 2023
• Last Update Submitted That Met QC Criteria: January 24, 2023
• Last Verified: January 1, 2023

More Information

Terms related to this study

• Keywords: antioxidants; polyphenols; strength; anthocyanins; nutritional ergogenics; sport supplementation
• Other Study ID Numbers: 1364-N-22

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No