The Association Between the Intraoperative Blood Pressure Changes and Whole Exome Genome

Association Between Whole Exon Sequencing and Arterial Stiffness in Patients With Intraoperative Hypotension)

The intraoperative blood pressure changes have been important for postoperative morbidity and mortality. However, some patients did not occur intraoperative hypotension but some patients would have severe intraoperative hypotension. It may be associated with genome related. In this hypothesis, we aim to elucidate the association between the whole exome genome and intraoperaive blood pressure changes.

Study Overview

• Status: Not yet recruiting
• Conditions: the Association Between the Arterial Stiffness, Intraoperative Blood Pressure Changes and Genetic Effect
• Intervention / Treatment: Other: this study did not involve interventions; it only observational study

Detailed Description

We aim to elucidate the association between the whole exome genome and intraoperative blood pressure changes.

We will enroll patients older than 20 years old and undergo elective general anesthesia.

Before anesthesia, we will obtain blood sample for whole exome genome test and give arterial line for intraoperative monitor.

After completing surgery, we will follow the patients' all postoperative major organ function.

We hope this study to be able to give us the more information about the specific genetic effect on the arterial stiffness and intraoperative blood pressure changes.

• Study Type: Observational
• Enrollment (Anticipated): 30

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 90 years (Adult, Older Adult)
• Accepts Healthy Volunteers: N/A
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

patients recieving general anesthesia

Description

Inclusion Criteria:

• elective general surgery

Exclusion Criteria:

• coagulopathy

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
patients undergoing general anesthesia	Other: this study did not involve interventions; it only observational study; this study did not involve interventions. This study is an observational study for elucidating the intraoperative blood pressure changes, artierial stiffness, and whole exome genome

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The association between the arterial stiffness and whole exome genome	using pearson correlation to describe the association	15 minutes

Collaborators and Investigators

• Sponsor: National Taiwan University Hospital

Study record dates

Study Major Dates

• Study Start (Anticipated): February 10, 2023
• Primary Completion (Anticipated): December 31, 2028
• Study Completion (Anticipated): December 31, 2030

Study Registration Dates

• First Submitted: February 7, 2023
• First Submitted That Met QC Criteria: February 7, 2023
• First Posted (Actual): February 15, 2023

Study Record Updates

• Last Update Posted (Actual): February 15, 2023
• Last Update Submitted That Met QC Criteria: February 7, 2023
• Last Verified: February 1, 2023

More Information

Terms related to this study

• Other Study ID Numbers: 202209125RINC

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: due to ethical concern

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No