Analysis of Radiographic and Kinematic Features in FAI Patients

Knee MRI and Markerless Motion Capture Analysis in Patients With Femoroacetabular Impingement Syndrome

The goal of this observational study is to describe the radiographic and kinematic features in patients with femoroacetabular impingement syndrome (FAI). The main questions it aims to answer are:

• Is structural knee abnormalities associated with knee pain symptoms in FAI patients?
• Does FAI patients with knee pain demonstrate unique kinematic characteristics？ Participants will receive routine preoperative radiographic examinations, which include ipsilateral knee MRI for the purpose of femoral version measurement. Participants will also receive markerless motion capture analysis.

Researchers will compare preoperative radiographic and kinematic features based on knee pain status, which is routinely collected as part of clinical investigation procedures.

Study Overview

• Status: Completed
• Conditions: Femoro Acetabular Impingement

Detailed Description

This observational study aims to study the association between preoperative subjective knee pain and baseline knee radiographic and kinematic characteristics. MRI of the ipsilateral knee is screened for structural abnormalities, including cartilage defects, meniscal tears and ligament injuries. Markerless motion capture data are evaluated for transverse plane kinematic features, with a primary focus on foot progression angles during normal gait.

• Study Type: Observational
• Enrollment (Actual): 93

Contacts and Locations

Study Locations

• China
  • Beijing, China, 100191
    • Peking University Third Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Consecutive patients diagnosed with FAI and admitted into the sports medicine department at Peking university third hospital for hip arthroscopic surgery by a single surgeon.

Description

Inclusion Criteria:

• (1) diagnosed with FAI based on clinical and radiographical findings;
• (2) failed conservative treatment for at least 6 months and indicated for surgical treatment;
• (3) received routine preoperative hip and ipsilateral knee MRI.

Exclusion Criteria:

• (1) history of fracture or surgery of hip and knee;
• (2) avascular necrosis;
• (3) Legg-Calve-Perthes disease;
• (4) Ehlers-Danlos syndrome;
• (5) pigmented villonodular synovitis (PVNS);
• (6) osteoid osteoma (OO);
• (7) synovial chondromatosis;
• (8) severe hip osteoarthritis (OA) with Tönnis grade > 1;
• (9) developmental dysplasia of hip (DDH)

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Ipsilateral knee pain group; Those FAI patients presenting with preoperative ipsilateral knee pain.
No ipsilateral knee pain group; Those FAI patients presenting without preoperative ipsilateral knee pain.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Preoperative radiographic cartilage defect of ipsilateral knee	On the same day of admission, patients receive routine preoperative MRI examination of the hip and ipsilateral knee for femoral version measurement. Radiographs of ipsilateral knee MRI are evaluated for the presence of structural knee abnormality. Radiographic signs suggesting cartilage defect of the patella, femur and the tibial plateau are collected.	Knee MRI radiographs are evaluated at baseline.
Preoperative radiographic meniscal tear of ipsilateral knee	On the same day of admission, patients receive routine preoperative MRI examination of the hip and ipsilateral knee for femoral version measurement. Radiographs of ipsilateral knee MRI are evaluated for the presence of structural knee abnormality. Radiographic signs suggesting lateral or medial meniscal tears are collected.	Knee MRI radiographs are evaluated at baseline.
Preoperative radiographic ligament ruptures of ipsilateral knee	On the same day of admission, patients receive routine preoperative MRI examination of the hip and ipsilateral knee for femoral version measurement. Radiographs of ipsilateral knee MRI are evaluated for the presence of structural knee abnormality. Radiographic signs suggesting ACL tears, PCL tears or collateral ligament ruptures are collected.	Knee MRI radiographs are evaluated at baseline.
Foot progression angle during normal gait	The next day after admission, patients undergo markerless motion capture evaluation after informed consents are obtained. Movements for motion capture include normal gait, stepping in place, single-leg stance, double-leg squat and forward lunge. Each movement is repeated 2 times. The entire data collection process for each patient takes approximately 120 seconds. Foot progression angle during gait are assessed with MATLAB in a retrospective fashion after completion of patient recruitment.	Motion capture data are assessed at baseline.

Collaborators and Investigators

• Sponsor: Peking University Third Hospital
• Investigators: Principal Investigator: Yan Xu, M.D., Peking University Third Hospital

Study record dates

Study Major Dates

• Study Start (Actual): September 1, 2021
• Primary Completion (Actual): February 28, 2022
• Study Completion (Actual): February 28, 2022

Study Registration Dates

• First Submitted: April 25, 2023
• First Submitted That Met QC Criteria: May 17, 2023
• First Posted (Actual): May 19, 2023

Study Record Updates

• Last Update Posted (Actual): May 19, 2023
• Last Update Submitted That Met QC Criteria: May 17, 2023
• Last Verified: April 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Joint Diseases; Musculoskeletal Diseases; Femoracetabular Impingement
• Other Study ID Numbers: S2021436

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No