Acute Phase Reactant in Non-COVID-19 Bacterial Pneumonia

Acute Phase Reactant in Non-COVID-19 Community Acquired Pneumonia

This study is a cross-sectional study, was conducted at Chest department of Kasr Al-ainy Hospital, Cairo university during the period between October 2020 and April 2021.

The aim of the work was to evaluate levels of acute phase reactants(APR) in Non-COVID-19 bacterial pneumonia, and to correlate between levels of APR and the disease severity.

Study Overview

• Status: Completed
• Conditions: Pneumonia; Acute-Phase Reaction
• Intervention / Treatment: Diagnostic test: Blood sampling

Detailed Description

51 patients were included in our study, diagnosed as Non-COVID pneumonia

Inclusion criteria:

1. PCR(polymerase chain reaction) negative for COVID.
2. All patients of both sexes with pneumonia .

Exclusion criteria:

1. Non pulmonary infections.
2. Post surgery patients.
3. Renal patients.
4. hepatic patients.
5. Cardiac patients.
6. Recent pulmonary embolism.

Methodology in details:

All patients were subjected to:

1. Full history with emphasis on:

   • Epidemiological features (age, gender).
   • Risk factors (smoking, DM).
   • Clinical presentation (cough, Fever and duration of illness).
2. Clinical examination (local chest examination).
3. Laboratory investigations: venous blood samples were taken to measure APR

• Study Type: Observational
• Enrollment (Actual): 51

Contacts and Locations

Study Locations

• Egypt
  • Cairo, Egypt, 11562
    • Kasr Alainy School of Medicine

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

All patients( 51 patients diagnosed as non-COVID19 Pneumonia) were subjected to:

1. Full historywith emphasis on:

   • Epidemiological features .
   • Risk factors (smoking, DM).
   • Clinical presentation (cough, Fever and duration of ilness).
2. Clinical examination (local chest examination).
3. Laboratory investigations: venous blood samples were taken for:• Complete blood picture, differential leucocytic count and platelets count, ESR ,CRP, d-dimer and ferritin

Description

Inclusion Criteria:

• COVID-19 negative bacterial pneumonia

Exclusion Criteria:

• COVID-19 positive
• other non-pulmonary infections

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
measurement of APR levels in non-Covid-19 pneumonia	assessment of the level of APR and its relation to disease severity	6 months

Collaborators and Investigators

• Sponsor: Cairo University

Study record dates

Study Major Dates

• Study Start (Actual): October 1, 2020
• Primary Completion (Actual): April 30, 2021
• Study Completion (Actual): May 30, 2021

Study Registration Dates

• First Submitted: June 28, 2023
• First Submitted That Met QC Criteria: June 28, 2023
• First Posted (Actual): July 3, 2023

Study Record Updates

• Last Update Posted (Actual): July 14, 2023
• Last Update Submitted That Met QC Criteria: July 12, 2023
• Last Verified: July 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Infections; Respiratory Tract Infections; Respiratory Tract Diseases; Lung Diseases; Inflammation; Pneumonia; Acute-Phase Reaction
• Other Study ID Numbers: MS-358-2020

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No