- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05955170
Tucatinib in Combination With Oral Etoposide andTrastuzumab in Patients With Metastatic HER2+ Breast Cancer (TUC-TOC)
Tucatinib in Combination With Oral Etoposide (VP16) - Trastuzumab in Patients With Metastatic HER2+ Breast Cancer After Progression Under Tucatinib-Capecitabine-Trastuzumab or Toxicity Related to Capecitabine: a Multicenter Phase II
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
This is an open-label, multicenter, phase II study to evaluate the efficacy, safety, tolerability, pharmacokinetics of the combination of tucatinib-Oral VP16-trastuzumab in patients with HER2-positive metastatic breast cancer (HER2+ MBC) after progression on tucatinib-capecitabine-trastuzumab or capecitabine-related toxicity.
The study has two sequential parts:
- Part 1 is a safety run-in part evaluating the safety of the combination to confirm the recommended dose;
- Part 2 will evaluate the efficacy of the combination at the recommended dose. Both parts will include patients with HER2 positive metastatic breast cancer.
In part 1, a D-dose is evaluated; only in case of unacceptable toxicity at the D-dose, a D-1 dose will be investigated.
In part 2, patients will be treated with oral VP16 at the dose recommended in part 1.
Dose reductions will be allowed on subsequent cycles in case of toxicity.
All enrolled patients will receive the combination of tucatinib, oral VP16, trastuzumab until disease progression, unacceptable toxicity, and withdrawal of patient consent, investigator decision, and loss to follow-up, death, patient non-compliance, or discontinuation of the study by the sponsor.
Tumor assessments should be performed according to RECIST v1.1 criteria at baseline and every 6 weeks (± 7 days) for the first 24 weeks, then every 9 weeks (± 7 days) until documented disease progression, withdrawal of consent, or death.
Study Type
Enrollment (Estimated)
Phase
- Phase 2
Contacts and Locations
Study Contact
- Name: Sandra Nespoulous
- Phone Number: 0147111654
- Email: drci.promotion@curie.fr
Study Contact Backup
- Name: Fouzia Azzouz
- Phone Number: 0147112366
- Email: drci.promotion@curie.fr
Study Locations
-
-
-
Avignon, France, 84000
- Not yet recruiting
- Institut Sainte Catherine
-
Contact:
- Julien GRENIER, MD
-
Principal Investigator:
- Julien GRENIER, MD
-
Caen, France, 14076
- Recruiting
- Centre François Baclesse
-
Contact:
- Christelle Levy, MD
-
Dijon, France, 21079
- Not yet recruiting
- Centre Georges-Francois Leclerc
-
Contact:
- Isabelle DESMOULIN, MD
-
Principal Investigator:
- Isabelle DESMOULIN, MD
-
Lille, France, 59020
- Not yet recruiting
- Centre Oscar Lambret
-
Contact:
- Stéphanie BECOURT, MD
-
Principal Investigator:
- Stéphanie BECOURT, MD
-
Montpellier, France, 34298
- Suspended
- Institut du Cancer Montpellier
-
Nantes, France, 44277
- Not yet recruiting
- Hopital Prive du Confluent
-
Contact:
- Cyriac BLONZ, MD
-
Principal Investigator:
- Cyriac BLONZ, MD
-
Paris, France, 75005
- Not yet recruiting
- Institut Curie
-
Contact:
- Delphine LOIRAT, MD
-
Principal Investigator:
- Delphine LOIRAT, MD
-
Paris, France, 75010
- Not yet recruiting
- Hopital Saint-Louis Ap-Hp Senopole
-
Contact:
- Emilie MOATI, MD
-
Principal Investigator:
- Emilie MOATI, MD
-
Plerin, France, 22190
- Not yet recruiting
- Centre CARIO-Hôpital Privé des Côtes d'Armor (HPCA)
-
Contact:
- Jérôme MARTIN-BABAU, MD
-
Principal Investigator:
- Jérôme Martin-Babau, MD
-
Saint Cloud, France, 92210
- Recruiting
- Institut Curie
-
Principal Investigator:
- Florence LEREBOURS, MD
-
Contact:
- Florence LEREBOURS, MD
-
Toulouse, France, 31059
- Suspended
- Oncopole Claudius Regaud
-
-
Clermont Ferrand
-
Clermont-Ferrand, Clermont Ferrand, France, 63011
- Suspended
- Centre Jean Perrin
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- First disease progression under tucatinib-capecitabine-trastuzumab. OR Medical contra-indication to initiate or continue capecitabine in association with tucatinib-trastuzumab (investigator's decision based on patient medical history, DPD deficiency and/or capecitabine grade 2 toxicity or higher).
- Age > 18 years,
- Histologically confirmed HER2+ breast carcinoma (ASCO/CAP guidelines) with archived tumor tissue available,
- Have a life expectancy of at least 3 months,
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1,
- Participants must be able to swallow capsules,
- Participants must be able and willing to be available for the duration of the study and are willing to follow study procedures,
- Measurable disease, assessed by RECIST version 1,
Patients with brain metastases are eligible:
- Unless urgent treatment is required
- If time since WBRT is ≥ 21 days prior to first dose of treatment, time since SRS is ≥ 7 days prior to first dose of treatment, or time since surgical resection is ≥ 28 days
- Relevant records of any CNS treatment must be available to allow for classification of target and non-target lesions
- Left ventricular ejection fraction (LVEF) ≥ 50% (within 4 weeks before inclusion)
Adequate organ function (obtained within 14 days prior to treatment start) as evidenced by:
o Absolute neutrophil count (ANC) ≥ 1.5 X 10^9/L
o Hemoglobin (Hgb) ≥ 9 g/dL
o Platelet count ≥ 100 X 10^9/L
- Bilirubin ≤ 1.5 X upper limit of normal (ULN), except for patients with a documented history of Gilbert's disease (≤ 2 X ULN)
- Alanine aminotransferase (ALT), and aspartate aminotransferase (AST) ≤ 2.5 X ULN (for patients with liver metastases ≤ 5 X ULN);
- Alkaline phosphatase (AP) ≤ 3 X ULN (for patients with liver metastases, ≤ 5 X ULN);
- Serum creatinine ≤ 1.5 mg/dL (133 μmol/L) or calculated creatinine clearance ≥ 50 mL/min (using Cockcroft-Gault formula).
- If the patient is female:
Women of childbearing potential (WCBP): negative serum pregnancy test. The patient must be willing to use effective methods of contraception. Patients must be postmenopausal, surgically infertile, or willing to use a physical barrier method of contraception in addition to an intrauterine device or hormonal contraception until at least 6 months after completion of study treatment,
If the patient is male:
Male patients must agree to use an acceptable method of contraception (e.g., condom) during the study and for 3 months after completion of investigational treatment, 14. Patients must be covered by a health insurance plan. 15. Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.
Exclusion Criteria:
Have previously been treated with:
a. lapatinib within 12 months of starting study treatment (except in cases where lapatinib was given for ≤ 21 days and was discontinued for reasons other than disease progression or severe toxicity) b. neratinib, afatinib, or other investigational HER2/ EGFR or HER2 TKI at any time previously (excepted for patients already under tucatinib who continue without interruption).
- Patients who are pre-treated with tucatinib and who received a decreased dose of tucatinib (<300mg twice daily) are not eligible in the safety run-in phase.
- Have used a strong CYP3A4 or CYP2C8 inhibitor within 5 half-lives of the inhibitor, or have used a strong CYP3A4 or CYP2C8 inducer within 5 days prior to first dose of study treatment (see Appendix 4 and 5)
- Patients unable for any reason to undergo MRI of the brain.
- Leptomeningeal metastases or brain metastases requiring immediate symptomatic treatment or a high dose of corticosteroid therapy (≥2mg/day dexamethasone or equivalent).
- Have poorly controlled (> 1/week) generalized or complex partial seizures, or manifest neurologic progression due to brain metastases notwithstanding CNS-directed therapy
Any toxicity related to prior cancer therapies that has not resolved to ≤ Grade 1 at time of treatment start, with the following exceptions:
- Alopecia and neuropathy (must have resolved to ≤ Grade 2)
- Congestive Heart Failure (must have been ≤ Grade 1 in severity at the time of occurrence and must have resolved completely)
- Anemia (must have resolved to ≤ Grade 2)
- Patients who have had a last dose of IV chemotherapy within 21 days, last dose of oral cytotoxic chemotherapy, radiotherapy, biological therapy, or investigational therapy within 14 days prior to treatment start. This does not apply to patients already under tucatinib who continue without interruption.
- Patients who have had any major surgery within 28 days prior to inclusion.
- Have evidence within 2 years of the start of study treatment of another malignancy that required systemic treatment. This does not apply to patients already under tucatinib who continue without interruption.
- Concomitant use of other agents for the treatment of cancer or any investigational agent(s).
- Women who are either pregnant, lactating, planning to get pregnant
Have a serious concomitant systemic disorder (eg, active infection or a gastrointestinal disorder causing clinically significant symptoms such as nausea, vomiting, diarrhea, or profound immune suppression) that, in the opinion of the investigator, would compromise the patient's ability to adhere to the protocol, including but not limited to the following:
- Have known human immunodeficiency virus (HIV) infection.
- Active hepatitis B or C virus infection (screening required) or have other known chronic liver disease
- Severe renal impairment, interstitial lung disease (ILD), severe dyspnea at rest or requiring oxygen therapy, liver disease diagnosed with Child-Pugh A or higher cirrhosis or history of major surgical resection involving the stomach or small bowel, or preexisting Crohn's disease or ulcerative colitis or a preexisting chronic condition resulting in clinically significant diarrhea.
Have clinically significant cardiopulmonary disease such as:
- ventricular arrhythmia requiring therapy,
- uncontrolled hypertension (defined as persistent systolic blood pressure > 150 mm Hg and/or diastolic blood pressure > 100 mm Hg on antihypertensive medications), or
- any history of symptomatic CHF
- severe dyspnea at rest (CTCAE Grade 3 or above) due to complications of advanced malignancy
- hypoxia requiring supplementary oxygen therapy except when oxygen therapy is needed only for obstructive sleep apnea
- presence of ≥ Grade 2 QTc prolongation on screening ECG
- conditions potentially resulting in drug-induced prolongation of the QT interval or torsade de pointes:
1. Congenital or acquired long QT syndrome 2. Family history of sudden death 3. History of previous drug induced QT prolongation 4. Current use of medications with known and accepted associated risk of QT prolongation (see row "Accepted Association" in Appendix 8 15. Have known myocardial infarction or unstable angina within 6 months prior to first dose of study treatment 16. Require therapy with warfarin or other coumarin derivatives (non-coumarin anticoagulants are allowed) 17. Have inability to swallow pills or significant gastrointestinal disease which would preclude the adequate oral absorption of medication 18. Patients with altered mental status or psychiatric disorder that, in the opinion of the investigator, would preclude a valid patient informed consent.
19. Person deprived of liberty or placed under a legal protection regime with representation of the person.
20. Inability to comply with medical monitoring of the trial for geographic, social or psychological reasons.
-
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Combination of tucatinib-Oral VP16-trastuzumab
The safety run in part will be a safety evaluation including 6 patients at dose D of Oral VP16 per day, trastuzumab 600mg SC flat dose or 6mg/kg IV every 3 weeks and tucatinib 300mg PO BID. The evaluable population for DLT in this Part 1 is defined as patients who have completed the first 2 cycles of treatment (i.e.6 weeks) and received 100% of the planned dose of tucatinib-Oral VP16-trastuzumab.Patients treated at Dose Recommended during the safety run-in part will be considered as evaluable for the part II. |
Combination of tucatinib-Oral VP16-trastuzumab
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Objective response rate (ORR
Time Frame: 6 months
|
The objective response rate (ORR) is defined as the best response defined as complete or partial response occurring within the first 6 months of treatment, assessed by the investigators (according to RECIST v1.1 criteria)
|
6 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Serious adverse events
Time Frame: From inclusion until 30 days after the last dose of IMP, up to 24 months
|
Serious adverse events (SAEs)according to NCI CTCAE v5.0, by grade and their relationship to tucatinib-Oral VP16-trastuzumab.
|
From inclusion until 30 days after the last dose of IMP, up to 24 months
|
Adverse events
Time Frame: From inclusion until 30 days after the last dose of IMP, up to 24 months
|
Adverse events (AEs) according to NCI CTCAE v5.0, by grade and their relationship to tucatinib-Oral VP16-trastuzumab.
|
From inclusion until 30 days after the last dose of IMP, up to 24 months
|
Progression free survival
Time Frame: From inclusion until Progression or Death, up to 24 months
|
Progression free survival (PFS) is defined as the time from the date of inclusion until progression per RECIST 1.1 as assessed by the investigator at local site or death due to any cause.
The measure of interest is the median PFS
|
From inclusion until Progression or Death, up to 24 months
|
Overall survival
Time Frame: From inclusion until Progression or Death, up to 24 months
|
Overall survival (OS) is defined as the time from inclusion to the date of death due to any cause.
The measure of interest is the median OS (if reached).
|
From inclusion until Progression or Death, up to 24 months
|
Duration of response
Time Frame: From inclusion until Progression or Death, up to 24 months
|
Duration of response (DoR) as defined as the time from the date of first documented response until date of documented progression per RECIST 1.1 as assessed by the investigator at local site or death due to any cause.
The measure of interest is the median DoR
|
From inclusion until Progression or Death, up to 24 months
|
Time to response
Time Frame: 6 months
|
Time to response (TTR) as defined as the time from the start of treatment to the first ORR observed for patients who achieved a CR or PR.
The measure of interest is the median TTR.
|
6 months
|
Clinical benefit rate
Time Frame: 6 months
|
Clinical benefit rate (CBR) is defined as the percentage of patients with CR, PR, or stable disease (SD) according to RECIST 1.1, as assessed by the investigator at the local site.
The measure of interest is CBR at 24 weeks
|
6 months
|
EQ-5D-5L scale
Time Frame: From inclusion until Progression or Death, up to 24 months
|
The measure of interest is the mean difference in the change from baseline in EQ-5D-5L scale.
Time to deterioration in pain, physical functioning, role functioning and global health status/QoL.
The EQ VAS score is rated on a scale of 0-100 points.
0 points correspond to the worst possible health status
|
From inclusion until Progression or Death, up to 24 months
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: François-Clément BIDARD, Institut Curie
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- IC 2021-06
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
IPD Sharing Time Frame
IPD Sharing Access Criteria
IPD Sharing Supporting Information Type
- STUDY_PROTOCOL
- SAP
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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