- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05955976
Characteristics of Hoffa Adipose Tissue and Intramuscular Adipose Tissue in the Quadriceps Muscle (ADIPENIGME)
Study to Compare the Characteristics of Hoffa Adipose Tissue and Intramuscular Adipose Tissue in the Quadriceps Muscle
Over the last few years, it has been suggested that Knee Ostheoarthritis (KOA) incidence and progression could potentially be related to skeletal muscle characteristics. In particular, weakness of the quadriceps muscle would be a key determinant of KOA. However the mechanisms underpinning the influence of skeletal muscle in the pathophysiology of ostheoarthritis (OA) are poorly understood.
Crosstalk between skeletal muscle and structures around and in the joint is of interest. In physical deconditioning and aging, it has been reported that skeletal muscle can be replaced by adipose tissue. Several factors involved in the development of OA but also of adipose tissue may be involved in these muscular changes. Of interest, in patients with KOA, quadriceps weakness is an ubiquitous clinical finding. Infiltration of adipose tissue in skeletal muscle has been shown to affect muscle strength and mobility and be linked to cartilage volume loss and the occurrence/progression of KOA.
The main objective of this study is to compare the characteristics of the Hoffa tissus and the intamuscular fat (IMF) tissus in the quadriceps muscle in patients with gonarthrosis requiring total knee prosthesis.
This is a single-centre study based on a collection of surgical waste and is categorized as Research Not Involving Human subjects.
Study Overview
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Contact
- Name: Christian ROUX, PUPH
- Phone Number: 0492035491
- Email: roux.c2@chu-nice.fr
Study Contact Backup
- Name: Jean-François GONCALVEZ, PUPH
- Phone Number: 0492035963
- Email: gonzalez.jf@chu-nice.fr
Study Locations
-
-
-
Nice, France, 06000
- Recruiting
- Nice University Hospital
-
Principal Investigator:
- Christian Roux
-
Contact:
- Christian Roux
- Phone Number: 0492035491
- Email: roux.c2@chu-nice.fr
-
Sub-Investigator:
- Jean-François GONZALEZ
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Adult patient, aged between 40 and 85 years
- Patient having a confirmed diagnosis of knee ostheoarthritis
- Patient undergoing a surgery for a total knee prosthesis for knee ostheoarthritis
Exclusion Criteria:
-
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Patients suffering of knee ostheoarthritis undergoing a surgery for a total knee prosthesis.
|
biopsy
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Comparison between Hoffa tissue and intramuscular fat tissue (quadriceps): adipose tissue size differences
Time Frame: 4 months
|
size mesured in mm
|
4 months
|
Comparison between Hoffa tissue and intramuscular fat tissue (quadriceps): lipid levels
Time Frame: 4 months
|
level mesured in %
|
4 months
|
Comparison between Hoffa tissue and intramuscular fat tissue (quadriceps):fibrotic tissue
Time Frame: 4 months
|
rate mesured in %
|
4 months
|
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 23Rhumato02
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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