Impact of Exercise Intervention on Well-being in Shift-working Acute Care Nurses (WELL_NURSE)

November 11, 2025 updated by: AdventHealth

Examining the Impact of a 12-week Worksite Exercise Training Intervention on Mental, Metabolic, Physical, Spiritual, and Occupational Well-being Among Acute Care Nurses: A Randomized, Controlled Mixed Methods Pilot Study

This is a randomized, wait-list control pilot study to analyze the impact of a 12-week exercise training intervention on post-traumatic growth and whole-person well-being (mental health, physical health, spiritual well-being, perceived social support, and occupational health) among shift-working acute care nurses within AdventHealth.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

This study has five phases: Phase I: Screening; Phase II: Baseline Assessments (Pre-Intervention); Phase III: Exercise training; Phase IV: Post-Intervention; and Phase V: Repeat assessments at 3-months and 6-months post-intervention.

Phase I (90 minutes): This phase consists of reviewing and obtaining consent, screening for inclusion/exclusion criteria, reviewing study details, and assessing the need for medical clearance to participate in the exercise intervention, and a single blood draw for fasted blood profiles.

Phase II (7 hours): Upon successful screening, all participants will complete baseline assessments.

Phase III (Exercise Training Group 34 hours/Wait-List Control 4.5 hours): Upon completion of Phase II, participants will be randomized to the exercise training intervention group or the wait-list control group.

Phase IV (7 hours): All participants will enter a post-intervention phase that includes repeat assessments of Phase II outcomes.

Phase V (~2 hours): A subset of psychometric questionnaires will be repeated 3- and 6-months post-exercise training intervention to ascertain sustainability of the intervention.

*Subjects randomized to the wait-list control group will be offered the exercise training intervention upon completion of the Phase V assessments.

Study Type

Interventional

Enrollment (Actual)

21

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Florida
      • Orlando, Florida, United States, 32803
        • AdventHealth

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion:

  1. Age 21-65 years
  2. Nurse working in an AdventHealth inpatient acute care setting
  3. Currently working as a shift-working acute care nurse within AdventHealth.
  4. Weight stable prior to beginning the study exercise training intervention.
  5. Able to speak and understand written and spoken English.
  6. Understands the procedures and agrees to participate by giving written informed consent.
  7. Willing and able to comply with scheduled visits, laboratory tests, and other study procedures including a 12-week exercise training program.

Exclusion Criteria:

  1. Positive urine pregnancy test prior to DEXA scan
  2. Uncontrolled Type 1 or Type 2 diabetes mellitus
  3. Bleeding disorders
  4. Acute or chronic infections
  5. Chronic obstructive pulmonary disease
  6. Renal insufficiency or nephritis
  7. Uncontrolled hypertension (BP>160 mmHg systolic or >100 mmHg diastolic)
  8. History of Cushing's disease or syndrome
  9. Active rheumatoid arthritis or other inflammatory rheumatic disorder
  10. Major surgery within 4 weeks prior to Screening
  11. Participation in studies involving investigational drug(s) within 30 days prior to Screening
  12. History or presence of cardiovascular disease (unstable angina, myocardial infarction or coronary revascularization within 6 months, presence of cardiac pacemaker, implanted cardiac defibrillator)
  13. Any malignancy not considered cured, except basal cell carcinoma and squamous cell carcinoma of the skin (a participant is considered cured if there has been no evidence of cancer recurrence in the previous 5 years)
  14. Presence of any condition that, in the opinion of the Investigator or medical investigator, compromises participant safety or data integrity or the participant's ability to complete study days.
  15. More than 1-day a week of intentional exercise
  16. Medically diagnosed sleep disorder
  17. Weight >450 lbs

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Exercise Training Group
Exercise intervention group will undergo a 12-week exercise program.
Behavioral: Exercise training group
12-Week Exercise intervention on mentaL, metabolic, physicaL, spiritual, social, and occupational well-being among shift-working acute care NURSE
Other: Wait-List Control Group
Wait-List control group will participate in visits every 4 weeks for data collection and periodic phone calls for monitoring. They will be offered the exercise training intervention option at conclusion.
Behavioral: Wait-List Control Group
Control group

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Post-traumatic growth
Time Frame: Group comparison baseline, 3 months, and 6 months follow-up
Post-traumatic growth inventory (PTGI) (21-item questionnaire with Likert scale of 0-5, with 0 for "I did not experience this change as a result of my crisis" and 5 for "I experienced this change to a very great degree as a result of my crisis")
Group comparison baseline, 3 months, and 6 months follow-up

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Depression
Time Frame: Group comparisons baseline, 3 months, and 6 months follow-up
Patient Health Questionnaire (PHQ-2) (2-items measuring depression using Likert scale of 0 to 3 with 0 for "not at all" and 3 for "nearly every day)
Group comparisons baseline, 3 months, and 6 months follow-up
Anxiety
Time Frame: Group comparisons baseline, 3 months, and 6 months follow-up
Generalized Anxiety Disorder Scale (GAD-2) (2-items measuring anxiety with 4-point Likert scale with 0 for "not at all" and 3 for "nearly every day")
Group comparisons baseline, 3 months, and 6 months follow-up
Professional Quality of Life for Health care workers
Time Frame: Group comparisons baseline, 3 months, and 6 months follow-up
Professional Quality of Life Health (Pro-QOL Health) (30-items covering five domains (6 items each domain): 1) Compassion Satisfaction, 2) Perceived Support, 3) Burnout, 4) Secondary Traumatic Stress, and 5) Moral Distress using a Likert scale of 1-5 with 1 for "never" and 5 for "very often")
Group comparisons baseline, 3 months, and 6 months follow-up
Cardiorespiratory fitness
Time Frame: Group comparisons baseline, 3 months follow-up
Cardiopulmonary exercise test (CPX-T). (Aerobic fitness will be determined by measuring maximal O2 consumption (VO2max) during a stationary bicycle test)
Group comparisons baseline, 3 months follow-up
24-H Physical activity patterns
Time Frame: Group comparisons baseline, 3 months follow-up
GT3-X-BT, ActiGraph, LLC) monitor integrates motion sensor data from the tri-axial accelerometer to estimate the energy cost of free-living activity
Group comparisons baseline, 3 months follow-up
Spiritual well-being
Time Frame: Group comparisons baseline, 3 months, and 6 months follow-up
FACIT Spiritual Well-Being (FACIT-Sp) Non-Illness Version (12-items with a 5-point Likert with total score range from 0-32 with higher scores indicating better QOL/spiritual well-being)
Group comparisons baseline, 3 months, and 6 months follow-up
Job Satisfaction
Time Frame: Group comparisons baseline, 3 months, and 6 months follow-up
Nurse Job Satisfaction Scale (7 items using a 5-point Likert scale from 1 for "strongly disagree" to 5 for "strongly agree")
Group comparisons baseline, 3 months, and 6 months follow-up
Missed Care
Time Frame: Group comparisons baseline, 3 months, and 6 months follow-up
NDNQI Index of Work Satisfaction missed care (Two multiple choice questions about the last shift worked)
Group comparisons baseline, 3 months, and 6 months follow-up
Work-related exhaustion
Time Frame: Group comparisons baseline, 3 months, and 6 months follow-up
Quality Work Competence (3-item subscale with 5-point Likert scale from 1 for "never" to 5 for "very often")
Group comparisons baseline, 3 months, and 6 months follow-up
Medical Errors
Time Frame: Group comparisons baseline, 3 months, and 6 months follow-up
Single-item medical error question.
Group comparisons baseline, 3 months, and 6 months follow-up
Sleep
Time Frame: Group comparisons baseline, week 12
GT3-X-BT, ActiGraph, LLC) monitor integrates motion sensor data from the tri-axial accelerometer sleep measurements to determine total sleep time, sleep efficiency, and sleep latency.
Group comparisons baseline, week 12
Sleep questionnaire
Time Frame: Group comparisons baseline, week 12
Morningness-eveningness questionnaire Self-Report version (MEQ-REV-SR) (4 multiple choice items)
Group comparisons baseline, week 12
Sleep diary
Time Frame: Group comparisons baseline, week 12
National sleep foundation 7-day sleep diary (7 items for am and 8 items for pm)
Group comparisons baseline, week 12
Cognitive Health
Time Frame: Group comparison baseline, 1 week follow-up
Workplace Cognitive Failure Scale (15 items about experiences during last work week with Likert scale from 1 for "never" to 5 for "very often")
Group comparison baseline, 1 week follow-up
Insulin resistance
Time Frame: Group comparison baseline, 1 week follow-up
Blood collection fasting glucose, fasting insulin, lipid panel profile
Group comparison baseline, 1 week follow-up
Weight
Time Frame: Group comparison baseline, week 1, week 4, week 8, week 12, 1 week follow-up
Weight in kilograms
Group comparison baseline, week 1, week 4, week 8, week 12, 1 week follow-up
Waist circumference
Time Frame: Group comparison baseline, week 1, week 4, week 8, week 12, 1 week follow-up
Waist circumference in centimeters
Group comparison baseline, week 1, week 4, week 8, week 12, 1 week follow-up
Body Mass Index
Time Frame: Group comparison baseline, week 1, week 4, week 8, week 12, 1 week follow-up
Calculated body mass index based on current weight in kilograms and height in centimeters taken at baseline
Group comparison baseline, week 1, week 4, week 8, week 12, 1 week follow-up
Body composition
Time Frame: Group comparison baseline, 1 week follow-up
DEXA scan
Group comparison baseline, 1 week follow-up
Nutrition
Time Frame: Group comparison baseline, 1 week follow-up
Diet history Questionnaire-III (DHQ-III) (A questionnaire on beverage and food intake over the past month with branching items on amount of consumption based on responses)
Group comparison baseline, 1 week follow-up
Physical condition - strength
Time Frame: Group comparison baseline, 1 week follow-up
Muscle power testing will be performed using a Biodex pneumatic-driven dynamometer
Group comparison baseline, 1 week follow-up
Physical Activity
Time Frame: Group comparison baseline, 1 week follow-up
International Physical Activity Questionnaire (IPAQ) (27 maximum branching items with 5 parts: 1) Job-related physical activity, 2) Transportation physical activity, 3) Housework, house maintenance, and caring for family, 4) Recreation, sport, and leisure-time physical activity, 5) Time spent sitting
Group comparison baseline, 1 week follow-up
Lifestyle Beliefs
Time Frame: Group comparison baseline, 1 week follow-up
Healthy Lifestyle Beliefs Scale (16 items with 5-point Likert scale from "Strongly Disagree" to "Strongly Agree"
Group comparison baseline, 1 week follow-up
Lifestyle Behaviors
Time Frame: Group comparison baseline, 1 week follow-up
Healthy Lifestyle Behaviors Scale (16 items with 5-point Likert scale from "Strongly Disagree" to "Strongly Agree"
Group comparison baseline, 1 week follow-up

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Adherence/Compliance
Time Frame: 1 week follow-up
Percentage of exercise session attendance (number of attended sessions/the number of scheduled sessions)
1 week follow-up

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

AdventHealth

Investigators

  • Principal Investigator: Andrea Brennan, PhD, AdventHealth

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 13, 2023

Primary Completion (Actual)

May 13, 2025

Study Completion (Actual)

May 13, 2025

Study Registration Dates

First Submitted

June 6, 2023

First Submitted That Met QC Criteria

July 28, 2023

First Posted (Actual)

August 1, 2023

Study Record Updates

Last Update Posted (Estimated)

November 13, 2025

Last Update Submitted That Met QC Criteria

November 11, 2025

Last Verified

September 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 1762353

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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