Impact of Physical and Occupational Therapy in New BMT Patients

Assessing the Impact of Physical and Occupational Therapy for Patients Admitted for Bone Marrow Transplant on Outcomes

This is a single-site, non-randomized, observational study designed to evaluate the impact of adding physical and occupational therapy consultation upon inpatient admission for a bone marrow transplantation (BMT). The purpose of this study is to investigate whether consultation with physical and occupational therapists as part of the general admission order set for patients scheduled for bone marrow transplant will result in reduced complications, morbidity, length of inpatient stay, 30-day readmission, and 90-day mortality. Baseline data collection will be used to determine eligibility. This study will be partially retrospective (pre-implementation of physical and occupational therapy consultation order) and partially prospective.

Study Overview

• Status: Completed
• Conditions: Bone Marrow Transplantation; Bone Marrow Disease
• Intervention / Treatment: Other: physical and occupational therapy consultation

• Study Type: Observational
• Enrollment (Actual): 75
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • North Carolina
    • Chapel Hill, North Carolina, United States, 27599
      • Lineberger Comphrehensive Cancer Center at University of North Carolina at Chapel Hill

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Subjects who are admitted for bone marrow transplantation (BMT) at the study site.

Description

Inclusion Criteria:

1. Age ≥ 18 years at the time of admission for bone marrow transplantation (BMT)
2. Received BMT

Exclusion Criteria:

1. No history of inpatient admission for BMT

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
physical and occupational therapy; Physical and occupational therapy consultation might be used to provide targeted prehabilitation interventions.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
30-day readmission	30-day readmission rates will be calculated using historical data (pre-intervention) and compared to rates once physical and occupational therapy consultation has been included in the inpatient admission order set for bone marrow transplantation (BMT).	Up to 30 days after bone marrow transplantation

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The feasibility	The proportion of individuals who received a physical and occupational therapy consultation in the prospective group.	1 day (the date of bone marrow transplantation)
Acute care length of stay	Acute care length of stay will be calculated using historical data (pre-intervention) and compared to rates once physical and occupational therapy consultation has been included in the inpatient admission order set for BMT.	Up to 90 days after bone marrow transplantation
Mortality rates	Mortality rates will be calculated by comparing, how many subjects died pre-intervention and post-intervention, using medical record data.	Up to 90 days after bone marrow transplantation
Complication types and rates	Complication types and rates will be calculated and compared pre-intervention and post-intervention using medical record data.	Up to 90 days after bone marrow transplantation

Collaborators and Investigators

• Sponsor: UNC Lineberger Comprehensive Cancer Center
• Investigators: Principal Investigator: Sasha Stephen, MD, UNC Lineberger Comprehensive Cancer Center

Publications and helpful links

Helpful Links

• University of North Carolina Lineberger Comprehensive Cancer Center Clinical Trials

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2023
• Primary Completion (Actual): December 4, 2024
• Study Completion (Actual): December 4, 2024

Study Registration Dates

• First Submitted: July 28, 2023
• First Submitted That Met QC Criteria: August 4, 2023
• First Posted (Actual): August 7, 2023

Study Record Updates

• Last Update Posted (Estimated): December 15, 2025
• Last Update Submitted That Met QC Criteria: December 5, 2025
• Last Verified: December 1, 2025

More Information

Terms related to this study

• Keywords: exercise; physical therapy
• Additional Relevant MeSH Terms: Hematologic Diseases; Behavior; Hemic and Lymphatic Diseases; Bone Marrow Diseases; Motor Activity
• Other Study ID Numbers: LCCC2252

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No