Coca-Cola Zero (®) Consumption on Night-call Inpatient Course and Mortality

Coke Zero for the Zero: A Study Examining the Effect of Coke Zero Consumption on Night Call Inpatient Course and Mortality

The purpose of this study is to determine the effect of coke zero consumption by night-call staffs on inpatient admission and mortality, and total sleep duration during the night-call duty. Coke Zero is a soft drink that is widely popular within the medical community, carrying the meaning of "zero", which to some, signifies the minimal level of morbidity and mortality that will occupy the on-call the night staffs.

Study Overview

• Status: Active, not recruiting
• Conditions: Mortality
• Intervention / Treatment: Other: Coke Zero; Other: Coke

Detailed Description

Previous studies have demonstrated that superstitions among the medical community have been prevalent and staffs regularly engaged in conforming to the superstitions because of their associations with workload, inpatient admissions and mortality. As such, the current study aims to evaluate whether the consumption of Coke Zero has an effects on patient admissions and mortality and the eventfulness of the night-call duties.

• Study Type: Interventional
• Enrollment (Estimated): 160
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Yu Heng Kwan, MD, PhD; Phone Number: 006590231226; Email: phakyh@nus.edu.sg

Study Locations

• Singapore
  • Singapore, Singapore, 169608
    • Singapore General Hospital
    • Contact: Yu Heng Kwan, MD, PhD; Phone Number: 006590231226; Email: phakyh@nus.edu.sg

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Doctors on the night-call roster at Singapore General Hospital

Exclusion Criteria

• Other allied health professionals or medical students

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Coke Zero Arm; The participant will be given a Coke Zero before each night-call duty for consumption.	Other: Coke Zero; Coca-Cola Zero Sugar drink will be given.
Active Comparator: Coke Arm; The participant will be given a Coke before each night-call duty for consumption.	Other: Coke; Coca-Cola drink will be given.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Inpatient Mortality	For patients assigned under the designated night-call doctor's care	The designated night-call doctor's shift from 5PM to 8AM the next day
Inpatient general ward admission	For patients assigned under the designated night-call doctor's care	The designated night-call doctor's shift from 5PM to 8AM the next day
Inpatient High Dependency/Intensive Care Unit Admission	For patients assigned under the designated night-call doctor's care	The designated night-call doctor's shift from 5PM to 8AM the next day

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Hours of sleep during the night-call	For the designated night-call doctor's care	The designated night-call doctor's shift from 5PM to 8AM the next day
Hours of shift during the night-call	For the designated night-call doctor's care	The designated night-call doctor's shift from 5PM to 8AM the next day
Number of steps walked by the night-call staff during the night-call	For the designated night-call doctor's care	The designated night-call doctor's shift from 5PM to 8AM the next day
Level of alertness of the night-call staff after the night-call	Measured using the Karolinska Sleepiness Scale and the Epworth Sleepiness Scale	The designated night-call doctor's shift from 5PM to 8AM the next day

Collaborators and Investigators

• Sponsor: Duke-NUS Graduate Medical School
• Investigators: Principal Investigator: Yu Heng Kwan, MD, PhD, SingHealth Internal Medicine Residency

Publications and helpful links

General Publications

• Tan MH, Lee Z, Ng B, Sim ES, Chua YY, Tien M, Ooi CJ. The Tao of bao: a randomised controlled trial examining the effect of steamed bun consumption on night-call inpatient course and mortality. Ann Acad Med Singap. 2008 Mar;37(3):255-3.

Study record dates

Study Major Dates

• Study Start (Actual): January 10, 2024
• Primary Completion (Actual): February 2, 2024
• Study Completion (Estimated): December 31, 2024

Study Registration Dates

• First Submitted: November 18, 2023
• First Submitted That Met QC Criteria: November 26, 2023
• First Posted (Actual): December 5, 2023

Study Record Updates

• Last Update Posted (Actual): February 20, 2024
• Last Update Submitted That Met QC Criteria: February 17, 2024
• Last Verified: February 1, 2024

More Information

Terms related to this study

• Keywords: Coke Zero; Night-call Staffs; Inpatient Admission; Inpatient Course; Inpatient Mortality
• Additional Relevant MeSH Terms: Physiological Effects of Drugs; Neurotransmitter Agents; Molecular Mechanisms of Pharmacological Action; Central Nervous System Depressants; Peripheral Nervous System Agents; Sensory System Agents; Anesthetics; Neurotransmitter Uptake Inhibitors; Membrane Transport Modulators; Dopamine Agents; Anesthetics, Local; Dopamine Uptake Inhibitors; Vasoconstrictor Agents; Cocaine
• Other Study ID Numbers: DukeNushssrkyh-01

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: There is currently no plan to share IPD to other researchers.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No