Association of Acne Vulgaris With Oral Hygiene and Gingivitis

Association of Acne Vulgaris With Oral Hygiene and Severity of Plaque-Induced Gingivitis in Puberty

The goal of this observational study is to learn about in the relationship between acne vulgaris and oral hygiene and gingivitis. The main questions it aims to answer are:

• Is there a relationship between the severity of acne vulgaris lesions and the severity of plaque-related gingivitis?
• Could oral hygiene or the severity of plaque-related gingivitis have an impact on the treatment of acne lesions?

Participants will;

• First be examined at the dermatology clinic.
• Then be examined at the periodontology clinic.
• Participants with severe acne vulgaris lesions will be examined a second time at the dermatology clinic. (1.5 months after the first examination)
• Regularly use the antibiotic containing 100 mg doxycycline prescribed in the dermatology clinic for acne treatment. (Patients deemed suitable by the dermatologist)

Study Overview

• Status: Not yet recruiting
• Conditions: Gingivitis; Acne Vulgaris; Oral Hygiene; Dental Plaque; Puberty
• Intervention / Treatment: Other: Periodontal examination

• Study Type: Observational
• Enrollment (Estimated): 60

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

Participants in puberty between the ages of 13-18.

Description

Inclusion Criteria:

• Being systemically healthy
• Not using any medication regularly
• Not having received acne treatment before
• Not having a known allergy to Doxycycline/Tetracycline antibiotics
• Not having received periodontal disease treatment in the last 6 months
• Not having taken antibiotics or anti-inflammatory drugs in the last month
• Not having used antiseptic mouthwash in the last month
• Being between the ages of 13-18
• No radiographic bone loss or clinical attachment loss
• Absence of any diagnosed psychiatric disease

Exclusion Criteria:

• Smoking
• Using antibiotics and anti-inflammatory drugs
• Having significant psychological problems
• Mouth breathing

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Group A; Patients with Allen-Smith acne score 0 and 2 (Mild lesions)	Other: Periodontal examination; Determining the patient's oral hygiene status and the severity of gingivitis. For this purpose, the non-invasive Löe-Silness plaque and gingival index system will be used.
Group B; Patients with Allen-Smith acne score 4 (Moderate lesions)	Other: Periodontal examination; Determining the patient's oral hygiene status and the severity of gingivitis. For this purpose, the non-invasive Löe-Silness plaque and gingival index system will be used.
Group C; Patients with Allen-Smith acne score 6 and 8 (Severe lesions)	Other: Periodontal examination; Determining the patient's oral hygiene status and the severity of gingivitis. For this purpose, the non-invasive Löe-Silness plaque and gingival index system will be used.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The relationship between acne vulgaris and the severity of gingivitis depending on the amount of plaque	Data from three groups will be presented as the correlation between the Gingival Index score and the Plaque Index score. The relationship between the severity of gingival inflammation depending on the amount of plaque and acne lesions will be evaluated.	Baseline
The relationship between acne vulgaris and oral hygiene	Describes the relationship between plaque index data obtained during periodontal examination of patients and acne lesions. According to the plaque index system, a score of "0" indicates the absence of plaque. A score of "1" refers to the amount of plaque that is not visible to the eye but detected by the periodontal probe. A score of "2" refers to the amount of plaque detectable visually. The highest score, "3", indicates excessive plaque accumulation.	Baseline
Relationship between acne vulgaris and gingival index	To compare gingival index values obtained during periodontal examination with acne vulgaris, regardless of plaque index values. According to the gingival index system, a score of "0" indicates completely healthy gums. A score of "1" indicates mild erythema and no bleeding on probing. A score of "2" indicates a small amount of bleeding on probing. The highest score, "3", indicates spontaneous or excessive gingival bleeding.	Baseline

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The relationship between response to medical treatment and severity of gingivitis depending on the amount of plaque	The relationship between the response to medical treatment at the end of 1.5 months from the beginning and the severity of gingivitis depending on the amount of plaque in Group C (severe periodontitis) patients	At the end of 1.5 months from the beginning
The relationship between response to medical treatment and oral hygiene	Response to medical treatment in Group C (severe periodontitis) patients at the end of 1.5 months from the beginning. The relationship between response to medical treatment and plaque index. According to the plaque index system, a score of "0" indicates the absence of plaque. A score of "1" refers to the amount of plaque that is not visible to the eye but detected by the periodontal probe. A score of "2" refers to the amount of plaque detectable visually. The highest score, "3", indicates excessive plaque accumulation.	At the end of 1.5 months from the beginning
The relationship between response to medical treatment and gingival index	Response to medical treatment in Group C (severe periodontitis) patients after 1.5 months from the beginning. The relationship between response to medical treatment and gingival index. According to the gingival index system, a score of "0" indicates completely healthy gums. A score of "1" indicates mild erythema and no bleeding on probing. A score of "2" indicates a small amount of bleeding on probing. The highest score, "3", indicates spontaneous or excessive gingival bleeding.	At the end of 1.5 months from the beginning

Collaborators and Investigators

• Sponsor: Erzincan University

Study record dates

Study Major Dates

• Study Start (Estimated): June 5, 2024
• Primary Completion (Estimated): June 15, 2024
• Study Completion (Estimated): July 15, 2024

Study Registration Dates

• First Submitted: January 24, 2024
• First Submitted That Met QC Criteria: January 24, 2024
• First Posted (Actual): February 1, 2024

Study Record Updates

• Last Update Posted (Actual): May 28, 2024
• Last Update Submitted That Met QC Criteria: May 24, 2024
• Last Verified: May 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Skin Diseases; Infections; Stomatognathic Diseases; Periodontal Diseases; Mouth Diseases; Gingival Diseases; Tooth Diseases; Acneiform Eruptions; Sebaceous Gland Diseases; Dental Deposits; Gingivitis; Acne Vulgaris; Dental Plaque
• Other Study ID Numbers: EUDF-OKUMUS-003

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No