Effects of Probiotic and HIIT in Obese Women

Effects of Probiotic With HIIT on Cardiorespiratory Endurance and Metabolism in Middle-Aged Obese Women

The aim of this study is to investigate whether there are the additive effects when implementing both high-intensity interval training (HIIT) and probiotics simultaneously on improving cardiorespiratory endurance and metabolism in middle-aged women.

Study Overview

• Status: Completed
• Conditions: Anthropometry; Cardiorespiratory Fitness; Metabolism
• Intervention / Treatment: Dietary supplement: Placebo supplementation; Dietary supplement: Probiotics supplementation; Behavioral: HIIT training

Detailed Description

High-intensity interval training (HIIT) is a time-efficiency exercise mode that has been shown to reduce body fat, fasting blood insulin levels, arterial stiffness, and aerobic capacity, helping to prevent and improve chronic diseases. Probiotics, on the other hand, have been found to have similar effects, including improving insulin sensitivity and endurance exercise performance, as well as reducing body fat. However, the additive effects of HIIT combined with probiotic supplements are unclear. In addition, on average, the life expectancy of women is longer than that of men. Middle-aged women are at high-risk for obesity and metabolic-related problems that threaten their long-term health. Therefore, whether the combination of HIIT and probiotics can be utilized to enhance the wellness of middle-aged women is the objective of this study.

• Study Type: Interventional
• Enrollment (Actual): 47
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Taiwan
  • Taipei, Taiwan
    • University of Taipei

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Female
• Age between 35-55 years old
• Total body fat percentage greater than 30%

Exclusion Criteria:

• Male
• Participants who were taking probiotics supplementation or antibiotics
• Percentage of total body fat less than 30%

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Health Services Research
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Triple

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo control (C); The subjects do not perform HIIT training, but consume one placebo packet every day on a fasting status for 8 weeks.	Dietary supplement: Placebo supplementation; Yeast powder replaces probiotics in each packet. Each participant consume one packet every day on a fasting status for 8 weeks.
Experimental: Probiotics supplementation (P); Each participant consume one probiotic packet every day on a fasting status for 8 weeks.	Dietary supplement: Probiotics supplementation; Probiotics, Lactiplantibacillus plantarum TWK10, are packaged in powder form. Each participant consume one packet every day on a fasting status for 8 weeks.
Experimental: HIIT intervention (H); HIIT training for 3 sessions per week and consume one placebo packet every day on a fasting status for 8 weeks.	Dietary supplement: Placebo supplementation; Yeast powder replaces probiotics in each packet. Each participant consume one packet every day on a fasting status for 8 weeks.; Behavioral: HIIT training; HIIT training is conduct at the intensity of 85-90% VO2max for 2 minutes with 1-minute inactive resting interval, repeating for 7 times. 3 sessions per week for 8 weeks.
Experimental: HIIT with probiotics intervention (HP); Conduct HIIT training 3 sessions per week for 8 weeks and consume one probiotic packet every day on a fasting status for 8 weeks.	Dietary supplement: Probiotics supplementation; Probiotics, Lactiplantibacillus plantarum TWK10, are packaged in powder form. Each participant consume one packet every day on a fasting status for 8 weeks.; Behavioral: HIIT training; HIIT training is conduct at the intensity of 85-90% VO2max for 2 minutes with 1-minute inactive resting interval, repeating for 7 times. 3 sessions per week for 8 weeks.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Height	Height in centimeters	8 weeks
Body weight	Weight in kilograms	8 weeks
Body mass index (BMI)	Calculated by: weight (kg)/ height (m^2)	8 weeks
Body fat percentage	Body fat percentage (%) is measured with Dual-energy X-ray absorptiometry (DEXA)	8 weeks
Waist circumference	Waist circumference in centimeters	8 weeks
Hip circumference	Hip circumference in centimeters	8 weeks
Maximum oxygen uptake (VO2max)	VO2max in ml/min/kg	8 weeks
Time to exhaustion (TTE)	TTE in seconds	8 weeks
Running economy (RE)	RE in ml/kg/km	8 weeks
Fasting blood glucose (FBG)	FBG in mg/dL	8 weeks
Total cholesterol (TC)	TC in mg/dL	8 weeks
Triglyceride (TG)	TG in mg/dL	8 weeks
High-density lipoprotein cholesterol (HDL-C)	HDL-C in mg/dL	8 weeks
Low-density lipoprotein cholesterol (LDL-C)	LDL-C in mg/dL	8 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Muscle mass	Muscle mass in kilograms is measured with DEXA	8 weeks
Fat mass	Fat mass in kilograms is measured with DEXA	8 weeks
Bone mineral density (BMD)	BMD in g/cm^2 is measured with DEXA	8 weeks
Caloric intake	Caloric intake in kcal/day	8 weeks

Collaborators and Investigators

• Sponsor: University of Taipei
• Investigators: Study Director: Chien-Wen Hou, Ph.D., University of Taipei

Study record dates

Study Major Dates

• Study Start (Actual): October 1, 2018
• Primary Completion (Actual): January 31, 2019
• Study Completion (Actual): March 1, 2019

Study Registration Dates

• First Submitted: February 13, 2024
• First Submitted That Met QC Criteria: February 22, 2024
• First Posted (Estimated): February 29, 2024

Study Record Updates

• Last Update Posted (Estimated): February 29, 2024
• Last Update Submitted That Met QC Criteria: February 22, 2024
• Last Verified: February 1, 2024

More Information

Terms related to this study

• Other Study ID Numbers: MOST 107-2410-H-277-003

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No