Complications of High Frequency Jet Ventilation

May 20, 2025 updated by: Erasme University Hospital

Complications of High Frequency Jet Ventilation During Bronchoscopy - a Retrospective Cohort Study

High frequency jet ventilation (HFJV) has been introduced in 1967 as technique allowing ventilation with simultaneous access to the airway for bronchoscopy. Continuous improvement in the technique has led to a large use during interventional bronchoscopy, especially in large centers. However, complications occuring during the use of HFJV are poorly known. In this retrospective cohort study, the charts of all patients who had a bronchoscopy with the use of HFJV between 2019 and 2023 in our hospital will be analyzed. Primary outcome will the description of all complications during HFJV. Complications are defined as:

  • Hypoxia: SpO2 < 90% for 1 min
  • Severe hypoxia: SpO2 < 85% for 1 min
  • Hemodynamic instability, defined as Arterial pressure < 90/60
  • Cardiac arrhythmia
  • Laryngospasm or bronchospasm
  • Barotrauma or volutrauma
  • Need for ICU admission

A model predicting the risk for developing any complication will be developped using 2 mathematical methods:

  • a multivariate analysis
  • a data mining approach

For both approaches, the following variables will be included in the model:

  • Age
  • Gender
  • Weight
  • Height
  • BMI
  • Smoking
  • Alcohol consumption
  • Consumption of Other drugs
  • ASA class
  • Obstructive pulmonary disease
  • Restrictive lung disease
  • COPD status (1, 2, 3, 4)
  • Interstitial lung disease

  • Lung tumor

    • Trachea location
    • Carina location
    • Bronchial location
  • Pulmonary or tracheal stenosis
  • Presence of stridor
  • Severe stenosis (< 6 mm)
  • Baseline SpO2 (pre-intervention)
  • Pre-intervention oxygen requirement Procedure
  • Duration (min)
  • Stent placement
  • Dilation
  • Laser treatment
  • Length of hospital stay Lung function tests
  • FEV1 (forced expiratory volume)
  • VC (Vital Capacity)
  • FEV1/VC (Tiffeneau ratio)
  • CPT (total lung capacity)
  • DLCO (carbon monoxide diffusion)

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

1385

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Belgium
      • Brussels, Belgium, 1070
        • Hopital Universitaire de Bruxelles - Hopital Erasme

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

All patients who underwent a bronchoscopy with the use of high frequency jet ventilation

Description

Inclusion Criteria:

  • All patients who underwent a bronchoscopy with the use of high frequency jet ventilation between January 1st, 2019 and December 31st, 2023 at Erasme University Hospital, Brussels

Exclusion Criteria:

  • Incomplete medical chart
  • Patient who expressed their opposition to the use of their medical data

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
HFJV
All patients who underwent bronchoscopy with the use of high frequency jet ventilation between January 1st 2019 and december 31st 2023.
Procedure: High frequency jet ventilation
Use of high frequency jet ventilation during bronchoscopy

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Occurence of complications
Time Frame: 6 hours

The occurence (%) of complications of HFJV will be analyzed. Definition of complications is one or more of the following events:

  • Hypoxia: SpO2 < 90% for 1 min (%)
  • Severe hypoxia: SpO2 < 85% for 1 min (%)
  • Hemodynamic instability, defined as Arterial pressure < 90/60 (%)
  • Cardiac arrhythmia (%)
  • Laryngospasm or bronchospasm (%)
  • Barotrauma or volutrauma (%)
  • Need for ICU admission (%)

Complications will be reported as overall complications (%) defined as the occurence of one or more of the listed events.

Frequency of single events will be reported separately (%). Descriptive statistics ( %, mean, standard deviation, median, interquartile range) will be used as appropriate.
6 hours

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Prediction model of complications
Time Frame: 6 hours

A model predicting the risk for developing any complication will be developped using 2 mathematical methods:

  • a multivariate analysis
  • a data mining approach
6 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Erasme University Hospital

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 3, 2024

Primary Completion (Actual)

March 19, 2024

Study Completion (Actual)

February 1, 2025

Study Registration Dates

First Submitted

February 12, 2024

First Submitted That Met QC Criteria

February 22, 2024

First Posted (Actual)

February 29, 2024

Study Record Updates

Last Update Posted (Actual)

May 21, 2025

Last Update Submitted That Met QC Criteria

May 20, 2025

Last Verified

May 1, 2025

More Information

Terms related to this study

Other Study ID Numbers

  • SRB2024016

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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