Risk Factors for Acute Kidney Injury in Patients Undergoing Arthroplasty

March 4, 2024 updated by: Sanem Cakar Turhan, Ankara University

Risk Factors for Acute Kidney Injury in Patients Undergoing Total Joint Arthroplasty

The authors aimed to determine the risk factors associated with postoperative acute kidney injury in patients undergoing total joint arthroplasty.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Aim: The primary aim of the current study is to determine the risk factors associated with postoperative acute kidney injury in patients undergoing total joint arthroplasty. Considering that this patient group is mostly composed of advanced age and comorbid patients, the secondary aim of the study is to identify risky patients with predictable risk factors and to chart a way to make preoperative optimizations of the patients before developing postoperative complications.

Materials and Methods: Patients who underwent joint arthroplasty between 2015 and 2020 in Ankara University Faculty of Medicine, Department of Orthopedics and Traumatology were included. Within the scope of the study, patients' gender, age, weight, height, body mass index values, smoking, American Society of Anesthesiologist (ASA) score, Charlson-Comorbidity Index score (CCI), type of operation, duration of surgery, presence of intraoperative hypotension, anesthesia method , diabetes, hypertension, coronary artery disease, presence of congestive heart failure, presence of preoperative anemia, preoperative uric acid and albumin level, use of nephrotoxic agents in the perioperative period, basal creatinine and glomerular filtration rate (GFR) values, platelet suspension in the perioperative period, erythrocyte suspension, Amounts of fresh frozen plasma transfusions, postoperative creatinine at 24 hours - 48 hours - discharge, GFR values and Kidney Disesae Improving Global Outcomes (KDIGO) scores, length of hospital stay and length of stay in the intensive care unit were evaluated.

Study Type

Observational

Enrollment (Actual)

911

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey
      • Ankara, Turkey
        • Ankara University Medical School Anesthesiology and ICU Department

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Patients aged above 18 years old undergoing arthroplasty surgery

Description

Inclusion Criteria:

  • Patients aged above 18 years old undergoing arthroplasty surgery

Exclusion Criteria:

  • Known acute renal failure or chronic renal failure
  • Patients aged below 18 years old
  • Patients refusing to participate to the study

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Acute kidney injury in patients undergoing arthroplasty surgery
Time Frame: Retrospective between 2015-2020
To determine the incidence of acute kidney injury in patients undergoing arthroplasty surgery
Retrospective between 2015-2020

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Risk factors causing acute kidney injury in patients undergoing arthroplasty surgery
Time Frame: Retrospective between 2015-2020
To determine the risk factors causing acute kidney injury in patients undergoing arthroplasty surgery
Retrospective between 2015-2020

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ankara University

Investigators

  • Study Chair: Sanem Çakar Turhan, Assoc. Prof., Ankara University Medical School, Department of Anesthesiology and ICU
  • Principal Investigator: Hazal Nur Tezel Kılıc, Specialist, Ankara University Medical School, Department of Anesthesiology and ICU
  • Principal Investigator: Suheyla Karadag Erkoc, Assoc. Prof., Ankara University Medical School, Department of Anesthesiology and ICU
  • Principal Investigator: Hakan Kocaoglu, Assoc. Prof., Ankara University Medical School, Department of Orthopedics and Traumatology Surgery

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 1, 2022

Primary Completion (Actual)

December 31, 2022

Study Completion (Actual)

December 31, 2022

Study Registration Dates

First Submitted

February 26, 2024

First Submitted That Met QC Criteria

March 4, 2024

First Posted (Estimated)

March 6, 2024

Study Record Updates

Last Update Posted (Estimated)

March 6, 2024

Last Update Submitted That Met QC Criteria

March 4, 2024

Last Verified

March 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • I05-310-22

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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