Inspiratory Muscle Training in Burned Adults (Burns)

Effects of Adding Inspiratory Muscle Training to Pulmonary Rehabilitation Program in Adults With Burn Injuries: A Randomized Controlled Trial

The study outlines burn injury impact, emphasizes need for long-term rehabilitation. Study assesses inspiratory muscle training efficacy in improving respiratory strength, lung function, and exercise capacity in adult burn patients.

Study Overview

• Status: Completed
• Conditions: Burn Injuries
• Intervention / Treatment: Other: inspiratory exercise; Other: Pulmonary rehabilitation

Detailed Description

The study aimed to evaluate the effectiveness of adding inspiratory muscle training to pulmonary rehabilitation in adult burn patients. Fifty-two participants were randomly assigned to either inspiratory muscle training plus pulmonary rehabilitation or pulmonary rehabilitation alone for 8 weeks. Inspiratory muscle training consisted of using a Powerbreathe device for inspiratory muscle strengthening.

• Study Type: Interventional
• Enrollment (Actual): 52
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Egypt
  • Dokki
    • Giza, Dokki, Egypt, 11432
      • Faculty of physical therapy, Cairo University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Burn-injured adults aged 20-49.
• Admitted to the clinic after acute treatment.
• Recovering from burns affecting at least 20% total body surface area.
• Partial or full-thickness burns.

Exclusion Criteria:

• Smokers.
• had open or unhealed wounds.
• had any known neurological deficit.
• neuromuscular diseases.
• musculoskeletal deformities.
• pulmonary diseases.
• severe cardiac problems.
• inability to participate in regular exercise.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Respiratory muscle training group; Received inspiratory muscle training plus pulmonary rehabilitation program. Powerbreathe device was used for the exercise of the inspiratory muscle strength. Strengthening the inspiratory muscles with the Powerbreathe is similar to weightlifting to strengthen other muscles in the body.	Other: inspiratory exercise; The training consisted of 6 sets of 30 breaths per day, divided into 2 sessions per day. A one-minute rest interval between each set. Training was prescribed 5 days a week for 8 weeks; Other Names: inspiratory muscle training; Other: Pulmonary rehabilitation; Four resistive exercises, aerobic exercise, and deep breathing exercises, five sessions per week for 8 weeks; Other Names: Resistance exercise
Experimental: Pulmonary rehabilitation group; Received pulmonary rehabilitation program for five sessions per week for 8 weeks. Four resistive exercises, aerobic exercise, and deep breathing exercises, aerobic conditioning exercises on the treadmill. All exercises were performed using variable resistance machines.	Other: Pulmonary rehabilitation; Four resistive exercises, aerobic exercise, and deep breathing exercises, five sessions per week for 8 weeks; Other Names: Resistance exercise

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
maximal inspiratory pressure	performed using an electronic respiratory pressure meter, measures inspiratory muscle strength	At the beginning of intervention
maximal inspiratory pressure	performed using an electronic respiratory pressure meter, measures inspiratory muscle strength	After 8 weeks of intervention
maximal expiratory pressure	performed using an electronic respiratory pressure meter, assesses expiratory muscle strength.	At the beginning of intervention
maximal expiratory pressure	performed using an electronic respiratory pressure meter, assesses expiratory muscle strength.	After 8 weeks of intervention
Forced expiratory volume in 1 second	performed using a spirometer	At the beginning of intervention
Forced expiratory volume in 1 second	performed using a spirometer	After 8 weeks of intervention
forced vital capacity	performed using a spirometer	At the beginning of intervention
forced vital capacity	performed using a spirometer	After 8 weeks of intervention
Forced expiratory volume in 1 second/ forced vital capacity ratio	performed using a spirometer	At the beginning of intervention
Forced expiratory volume in 1 second/ forced vital capacity ratio	performed using a spirometer	After 8 weeks of intervention

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Functional exercise capacity	assessed using the six-minute walk test	At the beginning of intervention
Functional exercise capacity	assessed using the six-minute walk test	After 8 weeks of intervention

Collaborators and Investigators

• Sponsor: Qassim University
• Collaborators: Cairo University
• Investigators: Principal Investigator: FatmaAlzahraa Kamel, PhD, Cairo University; Study Chair: Maged Basha, PhD, Qassim University

Publications and helpful links

General Publications

• Willis CE, Grisbrook TL, Elliott CM, Wood FM, Wallman KE, Reid SL. Pulmonary function, exercise capacity and physical activity participation in adults following burn. Burns. 2011 Dec;37(8):1326-33. doi: 10.1016/j.burns.2011.03.016. Epub 2011 May 6.
• Ozkal O, Topuz S, Karahan S, Erdem MM, Konan A, Yasti AC. Clinical predictors of pulmonary functions, respiratory/peripheral muscle strength and exercise capacity at discharge in adults with burn injury. Disabil Rehabil. 2021 Oct;43(20):2875-2881. doi: 10.1080/09638288.2020.1720320. Epub 2020 Jan 30.
• Gittings PM, Grisbrook TL, Edgar DW, Wood FM, Wand BM, O'Connell NE. Resistance training for rehabilitation after burn injury: A systematic literature review & meta-analysis. Burns. 2018 Jun;44(4):731-751. doi: 10.1016/j.burns.2017.08.009. Epub 2017 Oct 7. Erratum In: Burns. 2020 Aug;46(5):1240-1241.

Study record dates

Study Major Dates

• Study Start (Actual): January 15, 2021
• Primary Completion (Actual): June 16, 2022
• Study Completion (Actual): September 11, 2023

Study Registration Dates

• First Submitted: March 12, 2024
• First Submitted That Met QC Criteria: March 12, 2024
• First Posted (Actual): March 18, 2024

Study Record Updates

• Last Update Posted (Actual): March 18, 2024
• Last Update Submitted That Met QC Criteria: March 12, 2024
• Last Verified: March 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Wounds and Injuries; Burns
• Other Study ID Numbers: 004201

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Plan Description: The data sets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
• IPD Sharing Time Frame: 6 months after publication
• IPD Sharing Access Criteria: relevance to the topic of the study and approval of all co-authors within 1 month of receiving the request.
• IPD Sharing Supporting Information Type: STUDY_PROTOCOL

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No