Rehydration Efficiency With Different Sports Drinks (REHYDR8)

Rehydration After Exercise With High-electrolyte Sport Drink

It is well established that post-exercise rehydration with a carbohydrate-electrolyte solution is better when compared to plain water. However, most of the commercially available drinks today are high in carbohydrates and sodium with low potassium without other active ingredients. The aim of the present study is to examine the impact of a higher electrolyte sports drink compared with traditional sports drinks and water on the time course and extent of rehydration after exercise-induced dehydration

Study Overview

• Status: Completed
• Conditions: Dehydration
• Intervention / Treatment: Other: Water; Other: Gatorade; Other: BodyArmor; Other: GoodSport

Detailed Description

Dehydration:

Based on our previous work, dehydration will be accomplished on the morning of testing via mild exercise and heat exposure to elicit a body weight loss of -2%. The subjects will perform four bouts of 25-min low-intensity exercise and 5 min rest (alternating cycling & walking) or till they reach -2% of body weight dehydration.

Rehydration:

Following a 20 min rest in thermo-comfortable environment a dehydrated baseline blood sample will be taken, and subject will start the rehydration protocol.

The volunteers will consume one of the four drinks below in a cross over balance mode. During the first hour four equal doses will be consumed in15-min intervals at a total volume of 150% of their body weight loss.

Trials/Drinks (block randomization will be used to assign individual participants to each specific trial/drink using their ID number):

• Water
• GoodSport®
• Gatorade®
• BodyArmor®

Measurements:

All measurements will be performed at one of the test rooms at our lab facility that boarders the room where participants can relax and wait out the end of the study day. When certain measurements need to be performed they simply move from one room to the next. Duration of taking blood and urine samples will take not more than 30-90 seconds each, bioelectrical impedance will take a bit more time to ensure the body is in a stable rested state as a result measurement will be taken in 10 minutes, finally perceptual data will take 30-60 seconds to be reported. To allow to perform all measurements study days will take up to 7 hours. Therefore, there will be a separate space available that allows for self-study or watching TV that includes a chair and table to work on and a couch to relax.

Blood samples (8 per trial, maximal 12 minutes):

A total of eight 10 mL blood samples will be collected on the euhydrated baseline, dehydrated baseline and at 30, 60, 90, 120, 180, and 240 min of the rehydration period.

All samples will be analyzed for glucose, osmolality, total plasma protein, hematocrit, hemoglobin (for plasma volume changes), sodium, potassium, and chloride.

Urine samples (6 per trial, maximal 9 minutes):

Urine samples will be collected using ~900 mL cups at euhydrated baseline, dehydrated baseline and cumulative totals will be collected at 60, 120, 180, and 240 min of the rehydration period. All samples will be analyzed for urine osmolality, specific gravity, volume, sodium, and potassium.

Perceptual Data (6 per trial, maximal 9 minutes):

Thirst, stomach fullness, and taste, assessed via a visual analog scale

• Study Type: Interventional
• Enrollment (Actual): 12
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Arizona
    • Phoenix, Arizona, United States, 85004
      • Interdisciplinary Science and Technology Building 8

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Training > 2x per week
• Age 18-55 y
• stable weight for the last 2 months (<5 lbs. fluctuation)

Exclusion Criteria:

• night shifting work
• thyroid medication
• bariatric surgery
• cardiovascular disease
• renal disease
• hepatic disease
• Participating in another study at the same time
• Bodyweight <110 lbs.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Single

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Water; rehydration with Plain water	Other: Water; Plain water
Active Comparator: Gatorade; rehydration with Gatorade drink	Other: Gatorade; Sport Drink Gatorade
Active Comparator: BodyArmor; Rehydration with Body Armor Drink	Other: BodyArmor; Sport Drink BodyArmor
Experimental: GoodSport; Rehydration with Good Sport drink	Other: GoodSport; Sport Drink GoodSport

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Net Fluid Balance	Net fluid balance based on body weight changes during the 4 h of the rehydration period	3 hours of rehydration
Net Fluid Balance	Net fluid balance based on body weight changes during the 4 h of the rehydration period	4 hours of rehydration
Urine volume	cumulative Urine output during the rehydration period	3 hours of rehydration
Urine osmotic excretion	Urine osmotic excretion during rehydration	3 hours of rehydration
Urine osmotic excretion	Urine osmotic excretion during rehydration	4 hours of rehydration

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Stomach fullness	Assessed via a Visual Analog scale during rehydration	3 hours of rehydration
Stomach fullness	Assessed via a Visual Analog scale during rehydration. Scale is from 0-125mm with higher number indicating greater perception	4 hours of rehydration
Thirst	Assessed via a Visual Analog scale during rehydration. Scale is from 0-125mm with higher number indicating greater perception	3 hours of rehydration
Thirst	Assessed via a Visual Analog scale during rehydration. Scale is from 0-125mm with higher number indicating greater perception	4 hours of rehydration

Collaborators and Investigators

• Sponsor: Arizona State University

Study record dates

Study Major Dates

• Study Start (Actual): May 1, 2023
• Primary Completion (Actual): January 5, 2024
• Study Completion (Actual): January 12, 2024

Study Registration Dates

• First Submitted: August 23, 2023
• First Submitted That Met QC Criteria: May 14, 2024
• First Posted (Actual): May 16, 2024

Study Record Updates

• Last Update Posted (Actual): May 16, 2024
• Last Update Submitted That Met QC Criteria: May 14, 2024
• Last Verified: May 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Metabolic Diseases; Water-Electrolyte Imbalance; Dehydration
• Other Study ID Numbers: FP00034719

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No